Anderson NM, Simon MC (2020) The tumor microenvironment. Curr Biol 30:R921–R925. https://doi.org/10.1016/j.cub.2020.06.081

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blake JA, Harris MA (2008) The Gene Ontology (GO) project: structured vocabularies for molecular biology and their application to genome and expression analysis. Curr Protoc Bioinformatics Chapter 7:721–729. https://doi.org/10.1002/0471250953.bi0702s00

Article  Google Scholar 

Borden KL (1998) RING fingers and B-boxes: zinc-binding protein-protein interaction domains. Biochem Cell Biol 76:351–358. https://doi.org/10.1139/bcb-76-2-3-351

Article  CAS  PubMed  Google Scholar 

Cao J, Su B, Peng R, Tang H, Tu D, Tang Y, Zhou J, Jiang G, Jin S, Wang Q, Wang A, Liu R, Deng Q, Zhang C, Bai D (2022) Bioinformatics analysis of immune infiltrates and tripartite motif (TRIM) family genes in hepatocellular carcinoma. J Gastrointest Oncol 13:1942–1958. https://doi.org/10.21037/jgo-22-619

Article  PubMed  PubMed Central  Google Scholar 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi B, Varambally S (2017) UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. Neoplasia 19:649–658. https://doi.org/10.1016/j.neo.2017.05.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Wang Z, Ding Y, Qin Y (2023) Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma. Front Immunol 10(14):1133308. https://doi.org/10.3389/fimmu.2023.1133308

Article  CAS  Google Scholar 

Chiossone L, Dumas PY, Vienne M, Vivier E (2018) Natural killer cells and other innate lymphoid cells in cancer. Nat Rev Immunol 18:671–688. https://doi.org/10.1038/s41577-018-0061-z

Article  CAS  PubMed  Google Scholar 

Chung YL, Wu ML (2016) Dual oncogenic and tumor suppressor roles of the promyelocytic leukemia gene in hepatocarcinogenesis associated with hepatitis B virus surface antigen. Oncotarget 7:28393–28407. https://doi.org/10.18632/oncotarget.8613

Article  PubMed  PubMed Central  Google Scholar 

Couri T, Pillai A (2019) Goals and targets for personalized therapy for HCC. Hepatol Int 13:125–137. https://doi.org/10.1007/s12072-018-9919-1

Article  PubMed  Google Scholar 

Cui X, Lin Z, Chen Y, Mao X, Ni W, Liu J, Zhou H, Shan X, Chen L, Lv J, Shen Z, Duan C, Hu B, Ni R (2016) Upregulated TRIM32 correlates with enhanced cell proliferation and poor prognosis in hepatocellular carcinoma. Mol Cell Biochem 421:127–137. https://doi.org/10.1007/s11010-016-2793-z

Article  CAS  PubMed  Google Scholar 

Dai W, Wang J, Wang Z, Xiao Y, Li J, Hong L, Pei M, Zhang J, Yang P, Wu X, Tang W, Jiang X, Jiang P, Xiang L, Li A, Lin J, Liu S, Wang J (2021) Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma. Front Oncol 11:767644. https://doi.org/10.3389/fonc.2021.767644

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Silva S, Wu L (2011) TRIM5 acts as more than a retroviral restriction factor. Viruses 3:1204–1209. https://doi.org/10.3390/v3071204

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng L, Meng T, Chen L, Wei W, Wang P (2020) The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduct Target Ther 5:11. https://doi.org/10.1038/s41392-020-0107-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dranoff G (2004) Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 4:11–22. https://doi.org/10.1038/nrc1252

Article  CAS  PubMed  Google Scholar 

Fan W, Du F, Liu X (2019) TRIM66 confers tumorigenicity of hepatocellular carcinoma cells by regulating GSK-3beta-dependent Wnt/beta-catenin signaling. Eur J Pharmacol 850:109–117. https://doi.org/10.1016/j.ejphar.2019.01.054

Article  CAS  PubMed  Google Scholar 

Forner A, Reig M, Bruix J (2018) Hepatocellular carcinoma. Lancet 391:1301–1314. https://doi.org/10.1016/S0140-6736(18)30010-2

Article  PubMed  Google Scholar 

Guo P, Qiu Y, Ma X, Li T, Ma X, Zhu L, Lin Y, Han L (2018) Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis. Exp Cell Res 368:59–66. https://doi.org/10.1016/j.yexcr.2018.04.013

Article  CAS  PubMed  Google Scholar 

Han Y, Wang Y, Dong X, Sun D, Liu Z, Yue J, Wang H, Li T, Wang C (2023) TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment. Nucleic Acids Res 51:D1425–D1431. https://doi.org/10.1093/nar/gkac959

Article  PubMed  Google Scholar 

Hanzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics 14:7. https://doi.org/10.1186/1471-2105-14-7

Article  PubMed  PubMed Central  Google Scholar 

Hasegawa K, Kokudo N, Imamura H, Matsuyama Y, Aoki T, Minagawa M, Sano K, Sugawara Y, Takayama T, Makuuchi M (2005) Prognostic impact of anatomic resection for hepatocellular carcinoma. Ann Surg 242:252–259. https://doi.org/10.1097/01.sla.0000171307.37401.db

Article  PubMed  PubMed Central  Google Scholar 

Hatakeyama S (2017) TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis. Trends Biochem Sci 42:297–311. https://doi.org/10.1016/j.tibs.2017.01.002

Article  CAS  PubMed  Google Scholar 

Hatanaka T, Yata Y, Naganuma A, Kakizaki S (2023) Treatment Strategy for Intermediate-Stage Hepatocellular Carcinoma: Transarterial Chemoembolization, Systemic Therapy, and Conversion Therapy. Cancers (Basel) 15. https://doi.org/10.3390/cancers15061798

Herquel B, Ouararhni K, Martianov I, Le Gras S, Ye T, Keime C, Lerouge T, Jost B, Cammas F, Losson R, Davidson I (2013) Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA. Nat Struct Mol Biol 20:339–346. https://doi.org/10.1038/nsmb.2496

Article  CAS  PubMed  Google Scholar 

Hu X, Tang Z, Ma S, Yu Y, Chen X, Zang G (2019) Tripartite motif-containing protein 7 regulates hepatocellular carcinoma cell proliferation via the DUSP6/p38 pathway. Biochem Biophys Res Commun 511:889–895. https://doi.org/10.1016/j.bbrc.2019.02.001

Article  CAS  PubMed  Google Scholar 

Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R (2023) Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors. Nat Rev Gastroenterol Hepatol 20:37–49. https://doi.org/10.1038/s41575-022-00688-6

Article  PubMed  Google Scholar 

Iglesias-Escudero M, Arias-González N, Martínez-Cáceres E (2023) Regulatory cells and the effect of cancer immunotherapy. Mol Cancer 422(1):26. https://doi.org/10.1186/s12943-023-01714-0

Article  CAS  Google Scholar 

Jiang J, Yu C, Chen M, Tian S, Sun C (2015) Over-expression of TRIM37 promotes cell migration and metastasis in hepatocellular carcinoma by activating Wnt/beta-catenin signaling. Biochem Biophys Res Commun 464:1120–1127. https://doi.org/10.1016/j.bbrc.2015.07.089

Article  CAS  PubMed  Google Scholar 

Kanehisa M, Goto S (2000) KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28:27–30. https://doi.org/10.1093/nar/28.1.27

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, Ignat M, Zucman-Rossi J, Cammas F, Lerouge T, Thibault C, Metzger D, Chambon P, Losson R (2007) Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet 39:1500–1506. https://doi.org/10.1038/ng.2007.15

Article  CAS  PubMed  Google Scholar 

Koh CH, Lee S, Kwak M, Kim BS, Chung Y (2023) CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential. Exp Mol Med 55(11):2287–2299. https://doi.org/10.1038/s12276-023-01105-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koo SY, Park EJ, Noh HJ, Jo SM, Ko BK, Shin HJ, Lee CW (2023) Ubiquitination Links DNA Damage and Repair Signaling to Cancer Metabolism. Int J Mol Sci 24. https://doi.org/10.3390/ijms24098441

Langfelder P, Horvath S (2008) WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9:559. https://doi.org/10.1186/1471-2105-9-559

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B, Liu XS (2017) TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells. Cancer Res 77:e108–e110. https://doi.org/10.1158/0008-5472.CAN-17-0307

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Shao C, Shi Y, Han W (2018) Lessons learned from the blockade of immune checkpoints in cancer immunotherapy. J Hematol Oncol 11:31. https://doi.org/10.1186/s13045-018-0578-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Q, Han J, Yang Y, Chen Y (2022) PD-1/PD-L1 checkpoint inhibitors in advanced hepatocellular carcinoma immunotherapy. Front Immunol 13:1070961.