Dai YC, Zhou LW, Hattori T, et al. Ganoderma lingzhi (Polyporales, Basidiomycota): the scientific binomial for the widely cultivated medicinal fungus Lingzhi. Mycol Progress. 2017;6:1051–5.
Wachtel-Galor S, Yuen J, Buswell JA, Benzie IFF. Ganoderma lucidum (lingzhi or reishi): a medicinal mushroom. In: Benzie IFF, Wachtel-Galor S, editors. Herbal medicine: biomolecular and clinical aspects. 2nd ed. Boca Raton: CRC Press/Taylor & Francis; 2011.
Du Z, Dong CH, Wang K, Yao YJ. Classification, biological characteristics and cultivations of Ganoderma. Adv Exp Med Biol. 2019;1181:15–58.
Article CAS PubMed Google Scholar
Cheng CR, Yue QX, Wu ZY, et al. Cytotoxic triterpenoids from Ganoderma lucidum. Phytochemistry. 2010;71(13):1579–85.
Article CAS PubMed Google Scholar
Eo SK, Kim YS, Lee CK, Han SS. Antiviral activities of various water and methanol soluble substances isolated from Ganoderma lucidum. Ethnopharmacol. 1999;68(1–3):129–36.
Shah P, Modi HA, Shukla MD, Lahiri SK. Preliminary phytochemical analysis and antibacterial activity of Ganoderma lucidum collected from Dang District of Gujarat, India. Int J Curr Microbiol App Sci. 2014;3:246–55.
Cadar E, Negreanu-Pirjol T, Pascale C, et al. Natural bio-compounds from Ganoderma lucidum and their beneficial biological actions for anticancer application: a review. Antioxidants (Basel). 2023;12(11):1907.
Article CAS PubMed Google Scholar
Chan SW, Tomlinson B, Chan P, Lam CWK. The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharm Biol. 2021;59(1):1161–71.
Article CAS PubMed Google Scholar
Bishop KS, Kao CH, Xu Y, Glucina MP, Paterson RR, Ferguson LR. From 2000years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry. 2015;114:56–65.
Article CAS PubMed Google Scholar
Chen YY, Xu L, Ren Q, Yuan HC, Yang DH, Chen ZS, Wang N, Feng YB. Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives. Acta Materia Medica. 2023;2(1):106–25.
Akbar R, Yam WK. Interaction of ganoderic acid on HIV related target: molecular docking studies. Bioinformation. 2011;7(8):413–7.
Article PubMed PubMed Central Google Scholar
He X, Chen Y, Li Z, et al. Germplasm resources and secondary metabolism regulation in Reishi mushroom (Ganoderma lucidum). Chin Herb Med. 2023;15(3):376–82.
PubMed PubMed Central Google Scholar
Chen S, Xu J, Liu C, et al. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat Commun. 2012;3:913.
Kubota T, Asaka Y, et al. Structures of ganoderic acid A and B, two new lanostane type bitter triterpenes from Ganoderma lucidum (FR.) KARST. Helv Chim Acta. 1982;65(2):611–9.
Lixin X, Lijun Y, Songping H. Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice. Biochem Mol Toxicol. 2019;33(4): e22271.
Baby S, Johnson AJ, Govindan B. Secondary metabolites from Ganoderma. Phytochemistry. 2015;114:66–101.
Article CAS PubMed Google Scholar
Yuan W, Jiang C, Wang Q, et al. Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast. Nat Commun. 2022;13:7740.
Article CAS PubMed PubMed Central Google Scholar
Lin ZB, Zhang HN. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacol Sin. 2004;25(11):1387–95.
Nayak RN, Dixitraj PT, Nayak A, Bhat K. Evaluation of anti-microbial activity of spore powder of Ganoderma lucidum on clinical isolates of Prevotella intermedia: a pilot study. Contemp Clin Dent. 2015;6(Suppl 1):S248–52.
CAS PubMed PubMed Central Google Scholar
Ni T, Hu Y, Sun L, et al. Oral route of mini-proinsulin-expressing Ganoderma lucidum decreases blood glucose level in streptozocin-induced diabetic rats. Int J Mol Med. 2007;20(1):45–51.
Wu S. Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide. Int J Biol Macromol. 2018;118(Pt B):2001–5.
Article CAS PubMed Google Scholar
Guo C, Guo D, Fang L, et al. Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon. Carbohydr Polym. 2021;267: 118231.
Article CAS PubMed Google Scholar
Su L, Li D, Su J, et al. Polysaccharides of sporoderm-broken spore of Ganoderma lucidum modulate adaptive immune function via gut microbiota regulation. Evid Based Complement Alternat Med. 2021;2021:8842062.
Article PubMed PubMed Central Google Scholar
Lv XC, Wu Q, Cao YJ, et al. Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition. Food Funct. 2022;13(10):5820–37.
Article CAS PubMed Google Scholar
Kao CHJ, Jesuthasan AC, Bishop KS, Glucina MP, Ferguson LR. Anti-cancer activities of Ganoderma lucidum: active ingredients and pathways. Funct Foods Health Dis. 2013;3(2):48–65.
Wu G, Qian Z, Guo J, et al. Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells. Am J Chin Med. 2012;40(3):631–42.
Article CAS PubMed Google Scholar
Lin SB, Li CH, Lee SS, Kan LS. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci. 2003;72(21):2381–90.
Article CAS PubMed Google Scholar
Gill BS, Navgeet, Mehra R, Kumar V, Kumar S. Ganoderic acid, lanostanoid triterpene: a key player in apoptosis. Invest New Drugs. 2018;36(1):136–43.
Article CAS PubMed Google Scholar
Pozo FM, Hunter T, Zhang Y. The ‘New (Nu)-clear’ evidence for the tumor-driving role of PI3K. Acta Mater Med. 2022;1(2):193–6. https://doi.org/10.15212/amm-2022-0013.
Article PubMed PubMed Central Google Scholar
Wen S, An R, Li D, et al. Tea and Citrus maxima complex induces apoptosis of human liver cancer cells via PI3K/AKT/mtor pathway in vitro. Chin Herb Med. 2022;14(3):449–58.
PubMed PubMed Central Google Scholar
Geng XQ, Ma A, He JZ, et al. Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways. Acta Pharmacol Sin. 2020;41(5):670–7.
Article CAS PubMed Google Scholar
Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D. Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. Int J Mol Med. 2006;18(4):657–64.
Jiang J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappab signaling. Int J Mol Med. 2008;21(5):577–84.
Chen NH, Zhong JJ. P53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. Phytomedicine. 2011;18(8–9):719–25.
Article CAS PubMed Google Scholar
Xia J, Dai L, Wang L, Zhu J. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mtor activity. Chem Biol Interact. 2020;316: 108932.
Article CAS PubMed Google Scholar
Tang W, Liu JW, Zhao WM, Wei DZ, Zhong JJ. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci. 2006;80(3):205–11.
Article CAS PubMed Google Scholar
Chen NH, Liu JW, Zhong JJ. Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. Pharmacol Rep. 2010;62(1):150–63.
Article CAS PubMed Google Scholar
Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med. 2019;18(3):121–6.
Article PubMed PubMed Central Google Scholar
Lawrence T. The nuclear factor NF-kappab pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6): a001651.
Article PubMed PubMed Central Google Scholar
Zheng S, Ma J, Zhao X, Yu X, Ma Y. Ganoderic acid A attenuates IL-1β-induced inflammation in human nucleus pulposus cells through inhibiting the NF-κB pathway. Inflammation. 2022;45(2):851–62.
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