1Bristol Trials Centre, University of Bristol, Bristol, UK

2Warwick Clinical Trials Unit, University of Warwick, Coventry, UK

3Sydney Medical School, University of Sydney, Sydney, Australia

Reprint requests to: Sophie Rees, PhD, Bristol Trials Centre, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK. E-mail: [email protected].

The authors have declared they have no conflicts of interest.

IRB approvals: The study was approved by University of Warwick Biomedical and Scientific Research Ethics Committee (BSREC) in April 2021 (Reference: BSREC 81/20-21) and Northern Sydney Local Health District Human Research Ethics Committee in May 2021 (Reference: 2021/ETH00958).