Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.
Xu P, Zhang S, Cheng J, Cao B, Huang J, Li Y, et al. Prognostic value of tumour contour irregularity on surgical strategies for T1bN0M0 renal cell carcinoma: a multi-institutional study. Eur J Radiol. 2023;159:110665.
Porta C, Cosmai L, Leibovich BC, Powles T, Gallieni M, Bex A. The adjuvant treatment of kidney cancer: a multidisciplinary outlook. Nat Rev Nephrol. 2019;15:423–33.
Grimm M-O, Bex A, De Santis M, Ljungberg B, Catto JWF, Rouprêt M, et al. Safe use of immune checkpoint inhibitors in the multidisciplinary management of urological cancer: the European Association of Urology Position in 2019. Eur Urol. 2019;76:368–80.
Article CAS PubMed Google Scholar
Kotecha RR, Motzer RJ, Voss MH. Towards individualized therapy for metastatic renal cell carcinoma. Nat Rev Clin Oncol. 2019;16:621–33.
Article CAS PubMed Google Scholar
Golkaram M, Kuo F, Gupta S, Carlo MI, Salmans ML, Vijayaraghavan R, et al. Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape. Genome Med. 2022;14:143.
Article CAS PubMed PubMed Central Google Scholar
Vegliante R, Pastushenko I, Blanpain C. Deciphering functional tumor states at single-cell resolution. EMBO J. 2022;41:e109221.
Article CAS PubMed Google Scholar
Hu J, Chen Z, Bao L, Zhou L, Hou Y, Liu L, et al. Single-cell transcriptome analysis reveals intratumoral heterogeneity in ccRCC, which results in different clinical outcomes. Mol Ther. 2020;28:1658–72.
Article CAS PubMed PubMed Central Google Scholar
Borcherding N, Vishwakarma A, Voigt AP, Bellizzi A, Kaplan J, Nepple K, et al. Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Commun Biol. 2021;4:122.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, Narayanan SP, Mannan R, Raskind G, Wang X, Vats P, et al. Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response. Proc Natl Acad Sci USA. 2021;118:e2103240118.
Article CAS PubMed PubMed Central Google Scholar
Obradovic A, Chowdhury N, Haake SM, Ager C, Wang V, Vlahos L, et al. Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages. Cell. 2021;184:2988–3005.e16.
Article CAS PubMed PubMed Central Google Scholar
Li R, Ferdinand JR, Loudon KW, Bowyer GS, Laidlaw S, Muyas F, et al. Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer. Cancer Cell. 2022;40:1583–99.e10.
Article CAS PubMed PubMed Central Google Scholar
Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet. 2013;45:860–7.
Article CAS PubMed Google Scholar
Hörhold F, Eisel D, Oswald M, Kolte A, Röll D, Osen W, et al. Reprogramming of macrophages employing gene regulatory and metabolic network models. PLoS Comput Biol. 2020;16:e1007657.
Article PubMed PubMed Central Google Scholar
Becht E, McInnes L, Healy J, Dutertre C-A, Kwok IWH, Ng LG, et al. Dimensionality reduction for visualizing single-cell data using UMAP. Nat Biotechnol. https://doi.org/10.1038/nbt.4314 (2018).
Hu C, Li T, Xu Y, Zhang X, Li F, Bai J, et al. CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data. Nucleic Acids Res. 2022;51:D870–6.
Article PubMed Central Google Scholar
Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014;344:1396–401.
Article ADS CAS PubMed PubMed Central Google Scholar
Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq. Science. 2016;352:189–96.
Article ADS CAS PubMed PubMed Central Google Scholar
Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, et al. Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016;539:309.
Article ADS PubMed PubMed Central Google Scholar
Venteicher AS, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin MG, et al. Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science. 2017;355:eaai8478.
Article PubMed PubMed Central Google Scholar
Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, et al. Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer. Cell. 2017;171:1611–24.e24.
Article CAS PubMed PubMed Central Google Scholar
Aibar S, González-Blas CB, Moerman T, Huynh-Thu VA, Imrichova H, Hulselmans G, et al. SCENIC: single-cell regulatory network inference and clustering. Nat Methods. 2017;14:1083–6.
Article CAS PubMed PubMed Central Google Scholar
Qiu X, Mao Q, Tang Y, Wang L, Chawla R, Pliner HA, et al. Reversed graph embedding resolves complex single-cell trajectories. Nat Methods. 2017;14:979–82. https://doi.org/10.1038/nmeth.4402.
Article CAS PubMed PubMed Central Google Scholar
Yu G, Wang L-G, Han Y, He Q-Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284–7.
Article CAS PubMed PubMed Central Google Scholar
Jin S, Guerrero-Juarez CF, Zhang L, Chang I, Ramos R, Kuan C-H, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021;12:1088.
Article ADS CAS PubMed PubMed Central Google Scholar
Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol. 2019;37:773–82.
Article CAS PubMed PubMed Central Google Scholar
Jt L, We J, Hs P, Ae J, Jd S. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 2012;28:882–3.
Rüetschi U, Rymo L, Lindstedt S. Human 4-hydroxyphenylpyruvate dioxygenase gene (HPD). Genomics. 1997;44:292–9.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, et al. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020;580:530–5.
Article ADS CAS PubMed Google Scholar
Wang W, Yang C, Wang T, Deng H. Complex roles of nicotinamide N-methyltransferase in cancer progression. Cell Death Dis. 2022;13:267.
Article CAS PubMed PubMed Central Google Scholar
de la Rosa Rodriguez MA, Deng L, Gemmink A, van Weeghel M, Aoun ML, Warnecke C, et al. Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes. Mol Metab. 2021;47:101168.
Article PubMed PubMed Central Google Scholar
Winder WW. Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol. 2001;91:1017–28.
Article CAS PubMed Google Scholar
Zhao S, Li B, Zhao R, Pan Z, Zhang S, Qiu W, et al. Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-κB pathway. Oncogene. 2023;42:138–53.
Article CAS PubMed Google Scholar
Ma Y, Chen G, Yi J, Li Q, Tan Z, Fan W, et al. IRX3 plays an important role in the pathogenesis of metabolic-associated fatty liver disease by regulating hepatic lipid metabolism. Front Endocrinol. 2022;13:895593.
Eggink LL, Roby KF, Cote R, Kenneth Hoober J. An innovative immunotherapeutic strategy for ovarian cancer: CLEC10A and glycomimetic peptides. J Immunother Cancer. 2018;6:28.
Article PubMed PubMed Central Google Scholar
Sen P, Helmke A, Liao CM, Sörensen-Zender I, Rong S, Bräsen J-H, et al. SerpinB2 r
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