The pleiotropic nature of NONO, a master regulator of essential biological pathways in cancers

Knott GJ, Bond CS, Fox AH. The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold. Nucleic Acids Res. 2016;44:3989–4004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng P, Li L, Deng T, Liu Y, Ling N, Qiu S, et al. NONO and tumorigenesis: more than splicing. J Cell Mol Med. 2020;24:4368–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taiana E, Ronchetti D, Todoerti K, Nobili L, Tassone P, Amodio N, et al. LncRNA NEAT1 in Paraspeckles: a structural scaffold for cellular DNA damage response systems? Noncoding RNA. 2020;6:26.

CAS  PubMed  PubMed Central  Google Scholar 

Shav-Tal Y, Zipori D. PSF and p54(nrb)/NonO-multi-functional nuclear proteins. FEBS Lett. 2002;531:109–14.

Article  CAS  PubMed  Google Scholar 

Bond CS, Fox AH. Paraspeckles: nuclear bodies built on long noncoding RNA. J Cell Biol. 2009;186:637–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sabari BR, Dall’Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, et al. Coactivator condensation at super-enhancers links phase separation and gene control. Science. 2018;361:eaar3958.

Article  PubMed  PubMed Central  Google Scholar 

Alberti S, Dormann D. Liquid–liquid phase separation in disease. Annu Rev Genet. 2019;53:171–94.

Article  CAS  PubMed  Google Scholar 

Zbinden A, Pérez-Berlanga M, De Rossi P, Polymenidou M. Phase separation and neurodegenerative diseases: a disturbance in the force. Dev Cell. 2020;55:45–68.

Article  CAS  PubMed  Google Scholar 

Fan X-J, Wang Y-L, Zhao W-W, Bai S-M, Ma Y, Yin X-K, et al. NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation. Am J Cancer Res. 2021;11:2838–52.

CAS  PubMed  PubMed Central  Google Scholar 

Fox AH, Nakagawa S, Hirose T, Bond CS. Paraspeckles: where long noncoding RNA meets phase separation. Trends Biochem Sci. 2018;43:124–35.

Article  CAS  PubMed  Google Scholar 

Spegg V, Altmeyer M. Biomolecular condensates at sites of DNA damage: more than just a phase. DNA Repair (Amst). 2021;106:103179.

Article  CAS  PubMed  Google Scholar 

Zhang S, Cooper JA, Chong YS, Naveed A, Mayoh C, Jayatilleke N, et al. NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma. EMBO Rep. 2023;24:e54977.

Article  CAS  PubMed  Google Scholar 

Ma C, Karwacki-Neisius V, Tang H, Li W, Shi Z, Hu H, et al. Nono, a bivalent domain factor, regulates Erk signaling and mouse embryonic stem cell pluripotency. Cell Rep. 2016;17:997–1007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benegiamo G, Mure LS, Erikson G, Le HD, Moriggi E, Brown SA, et al. The RNA-binding protein NONO coordinates hepatic adaptation to feeding. Cell Metab. 2018;27:404–418.e7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiao R, Chen J-Y, Liang Z, Luo D, Chen G, Lu ZJ, et al. Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription. Cell. 2019;178:107–121.e18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Nostrand EL, Freese P, Pratt GA, Wang X, Wei X, Xiao R, et al. A large-scale binding and functional map of human RNA-binding proteins. Nature. 2020;583:711–9.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Emili A, Shales M, McCracken S, Xie W, Tucker PW, Kobayashi R, et al. Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD. RNA. 2002;8:1102–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng R, Hawkins I, Link AJ, Patton JG. The splicing factor PSF is part of a large complex that assembles in the absence of pre-mRNA and contains all five snRNPs. RNA Biol. 2006;3:69–76.

Article  CAS  PubMed  Google Scholar 

Basu A, Dong B, Krainer AR, Howe CC. The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Mol Cell Biol. 1997;17:677–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hallier M, Tavitian A, Moreau-Gachelin F. The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. J Biol Chem. 1996;271:11177–81.

Article  CAS  PubMed  Google Scholar 

Yadav SP, Hao H, Yang H-J, Kautzmann M-AI, Brooks M, Nellissery J, et al. The transcription-splicing protein NonO/p54nrb and three NonO-interacting proteins bind to distal enhancer region and augment rhodopsin expression. Hum Mol Genet. 2014;23:2132–44.

Article  CAS  PubMed  Google Scholar 

Kaneko S, Rozenblatt-Rosen O, Meyerson M, Manley JL. The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3’ processing and transcription termination. Genes Dev. 2007;21:1779–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Straub T, Knudsen BR, Boege F. PSF/p54(nrb) stimulates ‘jumping’ of DNA topoisomerase I between separate DNA helices. Biochemistry. 2000;39:7552–8.

Article  CAS  PubMed  Google Scholar 

Peng R, Dye BT, Pérez I, Barnard DC, Thompson AB, Patton JG. PSF and p54nrb bind a conserved stem in U5 snRNA. RNA. 2002;8:1334–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Izumi H, McCloskey A, Shinmyozu K, Ohno M. p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly. Nucleic Acids Res. 2014;42:3998–4007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salton M, Lerenthal Y, Wang S-Y, Chen DJ, Shiloh Y. Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle Georget Tex. 2010;9:1568–76.

Article  CAS  Google Scholar 

Li S, Kuhne WW, Kulharya A, Hudson FZ, Ha K, Cao Z, et al. Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance. Nucleic Acids Res. 2009;37:6746–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maier B, Kramer A. A NONO-gate times the cell cycle. Proc Natl Acad Sci USA. 2013;110:1565–6.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Kowalska E, Ripperger JA, Hoegger DC, Bruegger P, Buch T, Birchler T, et al. NONO couples the circadian clock to the cell cycle. Proc Natl Acad Sci USA. 2013;110:1592–9.

Article  ADS  CAS  PubMed  Google Scholar 

Kowalska E, Ripperger JA, Muheim C, Maier B, Kurihara Y, Fox AH, et al. Distinct roles of DBHS family members in the circadian transcriptional feedback loop. Mol Cell Biol. 2012;32:4585–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Li J-L, Lin S, Cao C, Gimbrone NT, Yang R, et al. cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth. J Clin Invest. 2016;126:2267–79.

Article  PubMed  PubMed Central  Google Scholar 

Yu T, Zhao Y, Hu Z, Li J, Chu D, Zhang J, et al. MetaLnc9 facilitates lung cancer metastasis via a PGK1-activated AKT/mTOR pathway. Cancer Res. 2017;77:5782–94.

Article  CAS  PubMed  Google Scholar 

Ho T-T, Huang J, Zhou N, Zhang Z, Koirala P, Zhou X, et al. Regulation of PCGEM1 by p54/nrb in prostate cancer. Sci Rep. 2016;6:34529.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, et al. Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth. Oncotarget. 2018;9:10510–24.

Article  PubMed  PubMed Central  Google Scholar 

Ronchetti D, Favasuli VK, Silvestris I, Todoerti K, Torricelli F, Bolli N, et al. Expression levels of NONO, a nuclear protein primarily involved in paraspeckles function, are associated with several deregulated molecular pathways and poor clinical outcome in multiple myeloma. Discov Oncol. 2022;13:124.

留言 (0)

沒有登入
gif