Al-Mashhadi RH, Sørensen CB, Kragh PM, Christoffersen C, Mortensen MB, Tolbod LP, Thim T, Du Y, Li J, Liu Y, Moldt B, Schmidt M, Vajta G, Larsen T, Purup S, Bolund L, Nielsen LB, Callesen H, Falk E, Mikkelsen JG, Bentzon JF (2013) Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Sci Transl Med 5:166ral. https://doi.org/10.1126/scitranslmed.3004853

Article  CAS  Google Scholar 

Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ (2018) The human heart contains distinct macrophage subsets with divergent origins and functions. Nat Med 24:1234–1245. https://doi.org/10.1038/s41591-018-0059-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beyersdorf N (2005) Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases. Ann Rheum Dis 64:iv91–iv95. https://doi.org/10.1136/ard.2005.042564

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bönner F, Gastl M, Nienhaus F, Rothe M, Jahn A, Pfeiler S, Gross U, Schultheiss H-P, Ibanez B, Kozerke S, Szendroedi J, Roden M, Westenfeld R, Schrader J, Flögel U, Heusch G, Kelm M (2022) Regional analysis of inflammation and contractile function in reperfused acute myocardial infarction by in vivo 19F cardiovascular magnetic resonance in pigs. Basic Res Cardiol 117:21. https://doi.org/10.1007/s00395-022-00928-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bøtker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femminò S, García-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhäuser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schlüter K-D, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G (2018) Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol 113:39. https://doi.org/10.1007/s00395-018-0696-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carrillo A, Chamorro S, Rodríguez-Gago M, Alvarez B, Molina MJ, Rodríguez-Barbosa JI, Sánchez A, Ramírez P, Muñoz A, Domínguez J, Parrilla P, Yélamos J (2002) Isolation and characterization of immortalized porcine aortic endothelial cell lines. Vet Immunol Immunopathol 89:91–98. https://doi.org/10.1016/s0165-2427(02)00170-8

Article  CAS  PubMed  Google Scholar 

Carta T, Razzuoli E, Fruscione F, Zinellu S, Meloni D, Anfossi A, Chessa B, Dei Giudici S, Graham SP, Oggiano A, Franzoni G (2021) Comparative phenotypic and functional analyses of the effects of IL-10 or TGF-β on porcine macrophages. Animals 11:1098. https://doi.org/10.3390/ani11041098

Article  PubMed  PubMed Central  Google Scholar 

Chang J, Nair V, Luk A, Butany J (2013) Pathology of myocardial infarction. Diagn Histopathol 19:7–12. https://doi.org/10.1016/j.mpdhp.2012.11.001

Article  Google Scholar 

Chen C, Perry TL, Chitko-McKown CG, Smith AD, Cheung L, Beshah E, Urban JF, Dawson HD (2019) The regulatory actions of retinoic acid on M2 polarization of porcine macrophages. Dev Comp Immunol 98:20–33. https://doi.org/10.1016/j.dci.2019.03.020

Article  CAS  PubMed  Google Scholar 

Christia P, Bujak M, Gonzalez-Quesada C, Chen W, Dobaczewski M, Reddy A, Frangogiannis NG (2013) Systematic characterization of myocardial inflammation, repair, and remodeling in a mouse model of reperfused myocardial infarction. J Histochem Cytochem 61:555–570. https://doi.org/10.1369/0022155413493912

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dawson HD, Lunney JK (2018) Porcine cluster of differentiation (CD) markers 2018 update. Res Vet Sci 118:199–246. https://doi.org/10.1016/j.rvsc.2018.02.007

Article  CAS  PubMed  Google Scholar 

Dawson HD, Smith AD, Chen C, Urban JF (2017) An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome. Vet Microbiol 202:2–15. https://doi.org/10.1016/j.vetmic.2016.05.013

Article  CAS  PubMed  Google Scholar 

Dewald O, Ren G, Duerr GD, Zoerlein M, Klemm C, Gersch C, Tincey S, Michael LH, Entman ML, Frangogiannis NG (2004) Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol 164:665–677. https://doi.org/10.1016/S0002-9440(10)63154-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dhanjal TS, Lellouche N, von Ruhland CJ, Abehsira G, Edwards DH, Dubois-Randé J-L, Moschonas K, Teiger E, Williams AJ, George CH (2017) Massive accumulation of myofibroblasts in the critical isthmus is associated with ventricular tachycardia inducibility in post-infarct swine heart. JACC Clin Electrophysiol 3:703–714. https://doi.org/10.1016/j.jacep.2016.11.010

Article  PubMed  PubMed Central  Google Scholar 

Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29:15–21. https://doi.org/10.1093/bioinformatics/bts635

Article  CAS  PubMed  Google Scholar 

Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HWM, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M (2012) Myocardial infarction accelerates atherosclerosis. Nature 487:325–329. https://doi.org/10.1038/nature11260

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Ezquerra A, Revilla C, Alvarez B, Pérez C, Alonso F, Domínguez J (2009) Porcine myelomonocytic markers and cell populations. Dev Comp Immunol 33:284–298. https://doi.org/10.1016/j.dci.2008.06.002

Article  CAS  PubMed  Google Scholar 

Fairbairn L, Kapetanovic R, Sester DP, Hume DA (2011) The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease. J Leukoc Biol 89:855–871. https://doi.org/10.1189/jlb.1110607

Article  CAS  PubMed  Google Scholar 

Garcia-Dorado D, Théroux P, Elizaga J, Galiñanes M, Solares J, Riesgo M, Gomez MJ, Garcia-Dorado A, Fernandez Aviles F (1987) Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion. Cardiovasc Res 21:537–544. https://doi.org/10.1093/cvr/21.7.537

Article  CAS  PubMed  Google Scholar 

Gerner W, Talker SC, Koinig HC, Sedlak C, Mair KH, Saalmüller A (2015) Phenotypic and functional differentiation of porcine αβ T cells: current knowledge and available tools. Mol Immunol 66:3–13. https://doi.org/10.1016/j.molimm.2014.10.025

Article  CAS  PubMed  Google Scholar 

Le Guern AC, Giovino MA, Abe M, Theodore PR, Qi J, Down JD, Sachs DH, Sykes M, Yang YG (2003) Stem cell activity of porcine c-kit+ hematopoietic cells. Exp Hematol 31:833–840. https://doi.org/10.1016/S0301-472X(03)00197-8

Article  CAS  PubMed  Google Scholar 

Hall C, Gehmlich K, Denning C, Pavlovic D (2021) Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease. J Am Heart Assoc 10:e019338. https://doi.org/10.1161/JAHA.120.019338

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heinrichs M, Ashour D, Siegel J, Büchner L, Wedekind G, Heinze KG, Arampatzi P, Saliba A-E, Cochain C, Hofmann U, Frantz S, Campos Ramos G (2021) The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism. Cardiovasc Res 117:2664–2676. https://doi.org/10.1093/cvr/cvab181

Article  CAS  PubMed  Google Scholar 

Heusch G (2019) The spleen in myocardial infarction. Circ Res 124:26–28. https://doi.org/10.1161/CIRCRESAHA.118.314331

Article  CAS  PubMed  Google Scholar 

Heusch G, Skyschally A, Schulz R (2011) The in-situ pig heart with regional ischemia/reperfusion - ready for translation. J Mol Cell Cardiol 50:951–963. https://doi.org/10.1016/j.yjmcc.2011.02.016

Article  CAS  PubMed  Google Scholar 

Hinkel R, Howe A, Renner S, Ng J, Lee S, Klett K, Kaczmarek V, Moretti A, Laugwitz K-L, Skroblin P, Mayr M, Milting H, Dendorfer A, Reichart B, Wolf E, Kupatt C (2017) Diabetes mellitus-induced microvascular destabilization in the myocardium. J Am Coll Cardiol 69:131–143. https://doi.org/10.1016/j.jacc.2016.10.058

Article  CAS  PubMed  Google Scholar 

Hobby ARH, Berretta RM, Eaton DM, Kubo H, Feldsott E, Yang Y, Headrick AL, Koch KA, Rubino M, Kurian J, Khan M, Tan Y, Mohsin S, Gallucci S, McKinsey TA, Houser SR (2021) Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype. Am J Physiol Circ Physiol 321:H684–H701. https://doi.org/10.1152/ajpheart.00304.2021

Article  CAS  Google Scholar 

Hofmann U, Beyersdorf N, Weirather J, Podolskaya A, Bauersachs J, Ertl G, Kerkau T, Frantz S (2012) Activation of CD4 + T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice. Circulation 125:1652–1663. https://doi.org/10.1161/CIRCULATIONAHA.111.044164

Article  CAS  PubMed  Google Scholar 

van Hout GPJ, Bosch L, Ellenbroek GHJM, de Haan JJ, van Solinge WW, Cooper MA, Arslan F, de Jager SCA, Robertson AAB, Pasterkamp G, Hoefer IE (2017) The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction. Eur Heart J 38:828–836. https://doi.org/10.1093/eurheartj/ehw247

Article  CAS  PubMed