Salvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway

Feigin VL, Norrving B, Mensah GA. Global burden of stroke. Circ Res. 2017;120(3):439–48.

Article  CAS  PubMed  Google Scholar 

Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, et al. Heart Disease and Stroke Statistics-2020 Update: a report from the American Heart Association. Circulation. 2020;141(9):e139–596.

Article  PubMed  Google Scholar 

Valery L, Benjamin A. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20(10):795–820.

Article  Google Scholar 

Feigin VL, Nguyen G, Cercy K, Johnson CO, Alam T, Parmar PG, Abajobir AA, Abate KH, Abd-Allah F, Abejie AN, et al. Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016. New Engl J Med. 2018;379(25):2429–37.

Article  PubMed  Google Scholar 

Hlavica M, Diepers M, Garcia-Esperon C, Ineichen BV, Nedeltchev K, Kahles T, Remonda L. Pharmacological recanalization therapy in acute ischemic stroke—evolution, current state and perspectives of intravenous and intra-arterial thrombolysis. J Neuroradiol. 2015;42(1):30–46.

Article  PubMed  Google Scholar 

Wang W, Jiang B, Sun H, Ru X, Sun D, Wang L, Wang L, Jiang Y, Li Y, Wang Y, et al. Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults. Circulation. 2017;135(8):759–71.

Article  PubMed  Google Scholar 

Wang X, Tsuji K, Lee SR, Ning M, Furie KL, Buchan AM, Lo EH. Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke. 2004;35(11 Suppl 1):2726–30.

Article  CAS  PubMed  Google Scholar 

Wardlaw JM, Murray V, Berge E, Del ZG, Sandercock P, Lindley RL, Cohen G. Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis. Lancet. 2012;379(9834):2364–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang S, Li T, Ji T, Yi W, Yang Z, Wang S, Yang Y, Gu C. AMPK: potential therapeutic target for ischemic stroke. Theranostics. 2018;8(16):4535–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Z, Lu J, Liu WW, Manaenko A, Hou X, Mei Q, Huang JL, Tang J, Zhang JH, Yao H, et al. Advances in stroke pharmacology. Pharmacol Therapeut. 2018;191:23–42.

Article  CAS  Google Scholar 

Luo C, Chen Q, Liu B, Wang S, Yu H, Guan X, Zhao Y, Wang Y. The extracts of angelica sinensis and cinnamomum cassia from oriental medicinal foods regulate inflammatory and autophagic pathways against neural injury after ischemic stroke. Oxid Med Cell Longev. 2021;2021:9663208.

Article  PubMed  PubMed Central  Google Scholar 

Anttila JE, Whitaker KW, Wires ES, Harvey BK, Airavaara M. Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors. Prog Neuro-Psychoph. 2017;79(Pt A):3–14.

Article  CAS  Google Scholar 

Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med. 2011;17(7):796–808.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukocyte Biol. 2010;87(5):779–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Y, Wang J, Wang Y, Yang GY. The biphasic function of microglia in ischemic stroke. Prog Neurobiol. 2017;157:247–72.

Article  CAS  PubMed  Google Scholar 

Khaksar S, Bigdeli MR. Correlation between cannabidiol-induced reduction of infarct volume and inflammatory factors expression in ischemic stroke model. Basic Clin Neurosci. 2017;8(2):139–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandes A, Miller-Fleming L, Pais TF. Microglia and inflammation: conspiracy, controversy or control? Cell Mol Life Sci. 2014;71(20):3969–85.

Article  CAS  PubMed  Google Scholar 

Xu P, Zhang X, Liu Q, Xie Y, Shi X, Chen J, Li Y, Guo H, Sun R, Hong Y, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019;10(8):555.

Article  PubMed  PubMed Central  Google Scholar 

Xu P, Hong Y, Xie Y, Yuan K, Li J, Sun R, Zhang X, Shi X, Li R, Wu J, et al. TREM-1 exacerbates neuroinflammatory injury via NLRP3 inflammasome-mediated pyroptosis in experimental subarachnoid hemorrhage. Transl Stroke Res. 2021;12(4):643–59.

Article  CAS  PubMed  Google Scholar 

Ai CB, Li LN. Stereostructure of salvianolic acid B and isolation of salvianolic acid C from Salvia miltiorrhiza. J Nat Prod. 1988;51(1):145–9.

Article  CAS  Google Scholar 

Tang HJ, Zhang XW, Yang L, Li W, Li JH, Wang JX, Chen J. Synthesis and evaluation of xanthine oxidase inhibitory and antioxidant activities of 2-arylbenzofuran derivatives based on salvianolic acid C. Eur J Med Chem. 2016;124:637–48.

Article  CAS  PubMed  Google Scholar 

Shen H, Pei H, Zhai L, Guan Q, Wang G. Salvianolic acid C improves cerebral ischemia reperfusion injury through suppressing microglial cell M1 polarization and promoting cerebral angiogenesis. Int Immunopharmacol. 2022;110: 109021.

Article  CAS  PubMed  Google Scholar 

Yang Y, He Y, Wei X, Wan H, Ding Z, Yang J, Zhou H. Network pharmacology and molecular docking-based mechanism study to reveal the protective effect of salvianolic acid C in a rat model of ischemic stroke. Front Pharmacol. 2021;12: 799448.

Article  CAS  PubMed  Google Scholar 

Herpich F, Rincon F. Management of acute ischemic stroke. Crit Care Med. 2020;48(11):1654–63.

Article  PubMed  PubMed Central  Google Scholar 

Muresanu DF, Strilciuc S, Stan A. Current drug treatment of acute ischemic stroke: challenges and opportunities. CNS Drugs. 2019;33(9):841–7.

Article  CAS  PubMed  Google Scholar 

Tao Y, Tian K, Chen J, Tan D, Liu Y, Xiong Y, Chen Z, Tian Y. Network pharmacology-based prediction of the active compounds, potential targets, and signaling pathways involved in Danshiliuhao granule for treatment of liver fibrosis. Evid-Based Compl Alt. 2019;2019:2630357.

Article  Google Scholar 

Yi P, Zhang Z, Huang S, Huang J, Peng W, Yang J. Integrated meta-analysis, network pharmacology, and molecular docking to investigate the efficacy and potential pharmacological mechanism of Kai-Xin-San on Alzheimer’s disease. Pharm Biol. 2020;58(1):932–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Liu H, Fang Q, He H, Lu X, Wang Y, Fan X. Shexiang Tongxin dropping pill protects against chronic heart failure in mice via inhibiting the ERK/MAPK and TGF-beta signaling pathways. Front Pharmacol. 2021;12: 796354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang C, Chen G, Tang G, Xu X, Feng Z, Lu Y, Chan Y, Wu J, Chen Y, Xu L, et al. Multi-component Chinese medicine formulas for drug discovery: state of the art and future perspectives. Acta Mater Med. 2023;2(1):106–25.

Google Scholar 

Xu XJ, Long JB, Jin KY, Chen LB, Lu XY, Fan XH. Danshen-Chuanxiongqin injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-kappaB pathway in tMCAO mice. Chin J Nat Med. 2021;19(10):772–83.

CAS  PubMed  Google Scholar 

Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20(1):84–91.

Article  CAS  PubMed  Google Scholar 

Guo Q, Zhang YC, Wang W, Wang YQ, Liu Y, Yang Z, Zhao MM, Feng N, Wang YH, Zhang XW, et al. Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. Pharmacol Res. 2022;176: 106046.

Article  CAS  PubMed  Google Scholar 

Wu XL, Lu SS, Liu MR, Tang WD, Chen JZ, Zheng YR, Ahsan A, Cao M, Jiang L, Hu WW, et al. Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury. Acta Pharmacol Sin. 2020;41(8):1016–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu YF, Zhang L, Wu Q, Feng LY. Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochromec/caspase3/HDAC4 pathway. Acta Pharmacol Sin. 2022;43(2):273–84.

Article  CAS  PubMed  Google Scholar 

Liao J, Hao C, Huang W, Shao X, Song Y, Liu L, Ai N, Fan X. Network pharmacology study reveals energy metabolism and apoptosis pathways-mediated cardioprotective effects of Shenqi Fuzheng. J Ethnopharmacol. 2018;227:155–65.

Article  PubMed  Google Scholar 

Wu L, Wang Y, Li Z, Zhang B, Cheng Y, Fan X. Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology. Chin Med-UK. 2014;9:24.

Article 

留言 (0)

沒有登入
gif