Morelli AE, et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood. 2004;104(10):3257–66.

Article  CAS  PubMed  Google Scholar 

Villarroya-Beltri C, et al. Sorting it out: regulation of exosome loading. Semin Cancer Biol. 2014;28:-13.

Fader CM, et al. TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta Mol Cell Res. 2009;1793(12):1901–16.

Article  CAS  Google Scholar 

Rodrigues M, et al. Role of extracellular vesicles in viral and bacterial infections: pathogenesis, diagnostics, and therapeutics. Theranostics. 2018;8(10):2709–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El-Andaloussi S, et al. Exosome-mediated delivery of siRNA in vitro and in vivo. Nat Protoc. 2012;7(12):2112–26.

Article  CAS  PubMed  Google Scholar 

Kamerkar S, et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017;546(7659):498–503.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Montecalvo A, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012;119(3):756–66.

Article  MathSciNet  CAS  PubMed  PubMed Central  Google Scholar 

de Abreu RC, et al. Exogenous loading of miRNAs into small extracellular vesicles. J Extracell Vesicles. 2021;10(10):e12111.

Article  PubMed  PubMed Central  Google Scholar 

Alvarez-Erviti L, et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29(4):341–5.

Article  CAS  PubMed  Google Scholar 

Kim MS, et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine. 2016;12(3):655–64.

Article  CAS  PubMed  Google Scholar 

Sato YT, et al. Engineering hybrid exosomes by membrane fusion with liposomes. Sci Rep. 2016;6:21933.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Bartel DP. Metazoan microRNAs. Cell. 2018;173(1):20–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ranganath P. MicroRNA-155 and its role in malignant hematopoiesis. Biomark Insights. 2015;10:95–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cardoso AL, et al. miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production. Immunology. 2012;135(1):73–88.

Article  MathSciNet  CAS  PubMed  PubMed Central  Google Scholar 

Giri BR, Mahato RI, Cheng G. Roles of microRNAs in T cell immunity: implications for strategy development against infectious diseases. Med Res Rev. 2019;39(2):706–32.

Article  PubMed  Google Scholar 

Zhang ZT, et al. Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway. Inflammopharmacology. 2023;31(1):423–38.

Article  PubMed  Google Scholar 

Li S, et al. Characterization of microRNA cargo of extracellular vesicles isolated from the plasma of Schistosoma japonicum-infected mice. Front Cell Infect Microbiol. 2022;12: 803242.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng Z, et al. Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity. Theranostics. 2021;11(9):4351–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–8.

Article  CAS  PubMed  Google Scholar 

Watanabe S, et al. The role of macrophages in the resolution of inflammation. J Clin Invest. 2019;129(7):2619–28.

Article  PubMed  PubMed Central  Google Scholar 

Vannella KM, Wynn TA. Mechanisms of organ injury and repair by macrophages. Annu Rev Physiol. 2017;79:593–617.

Article  CAS  PubMed  Google Scholar 

Villarroya-Beltri C, et al. Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun. 2013;4:2980.

Article  PubMed  ADS  Google Scholar 

Torralba D, et al. Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Nat Commun. 2018;9(1):2658.

Article  PubMed  PubMed Central  ADS  Google Scholar 

Wahlgren J, et al. Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling. PLoS ONE. 2012;7(11):e49723.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Mittelbrunn M, et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun. 2011;2(1):282.

Article  PubMed  ADS  Google Scholar 

Cai Z, et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J Immunol. 2012;188(12):5954–61.

Article  CAS  PubMed  Google Scholar 

Witwer KW, Wolfram J. Extracellular vesicles versus synthetic nanoparticles for drug delivery. Nat Rev Mater. 2021;6(2):103–6.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Ohno S, et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol Ther. 2013;21(1):185–91.

Article  CAS  PubMed  Google Scholar 

Czernek L, Pęczek Ł, Düchler M. Small extracellular vesicles loaded with immunosuppressive mirnas leads to an inhibition of dendritic cell maturation. Arch Immunol Ther Exp. 2022;70(1):27.

Article  CAS  Google Scholar 

Buzas EI. The roles of extracellular vesicles in the immune system. Nat Rev Immunol. 2023;23(4):236–50.

Article  CAS  PubMed  Google Scholar 

Meizlish ML, et al. Tissue homeostasis and inflammation. Annu Rev Immunol. 2021;39:557–81.

Article  CAS  PubMed  Google Scholar 

Kurowska-Stolarska M, et al. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci USA. 2011;108(27):11193–8.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Jing W, et al. CRISPR/CAS9-mediated genome editing of miRNA-155 inhibits proinflammatory cytokine production by RAW264. 7 cells. BioMed Res Int. 2015:326042.

Kim H. The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages. Sci Rep. 2017;7(1):7591.

Article  PubMed  PubMed Central  ADS  Google Scholar 

He M, et al. MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPβ. Cell Mol Immunol. 2009;6(5):343–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez-Nunez RT, Louafi F, Sanchez-Elsner T. The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor α1 (IL13Rα1). J Biol Chem. 2011;286(3):1786–94.

Article  CAS  PubMed  Google Scholar 

Louafi F, Martinez-Nunez RT, Sanchez-Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-β. J Biol Chem. 2010;285(53):41328–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salvi V, et al. Cytokine targeting by miRNAs in autoimmune diseases. Front Immunol. 2019;10:15.