Overview of Diabetes. Available from: https://www.who.int/health-topics/diabetes/diabetes#tab=tab_1.

Perry CM. Liraglutide: a review of its use in the management of type 2 diabetes mellitus. Drugs. 2011;71(17):2347–73.

Article  CAS  PubMed  Google Scholar 

Dumont C, Beloqui A, Miolane C, Bourgeois S, Préat V, Fessi H, Jannin V. Solid lipid nanocarriers diffuse effectively through mucus and enter intestinal cells – but where is my peptide? Int J Pharm. 2020;586:119581.

Article  CAS  PubMed  Google Scholar 

Meece J. Pharmacokinetics and pharmacodynamics of liraglutide, a long-acting, potent glucagon-like peptide-1 analog. Pharmacotherapy. 2009;29(12 Pt 2):33S-42S.

CAS  PubMed  Google Scholar 

Tran KL, Park YI, Pandya S, Muliyil NJ, Jensen BD, Huynh K, Nguyen QT. Overview of glucagon-like peptide-1 receptor agonists for the treatment of patients with type 2 diabetes. Am Health Drug Benefits. 2017;10(4):178–88.

PubMed  PubMed Central  Google Scholar 

Adhikari BB, Goodson JL, Chu SY, Rota PA, Meltzer MI. Assessing the potential cost-effectiveness of microneedle patches in childhood measles vaccination programs: the case for further research and development. Drugs R D. 2016;16(4):327–38.

Article  PubMed  PubMed Central  Google Scholar 

Usach I, Martinez R, Festini T, Peris JE. Subcutaneous injection of drugs: literature review of factors influencing pain sensation at the injection site. Adv Ther. 2019;36(11):2986–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamplin SA, Davidson D, Powis B, O’Leary Z. Issues and options for the safe destruction and disposal of used injection materials. Waste Manag. 2005;25(6):655–65.

Article  CAS  PubMed  Google Scholar 

Stolbrink M, Thomson H, Hadfield RM, Ozoh OB, Nantanda R, Jayasooriya S, Allwood B, Halpin DMG, Salvi S, de Oca MM, Mortimer K, Rylance S. The availability, cost, and affordability of essential medicines for asthma and COPD in low-income and middle-income countries: a systematic review. Lancet Glob Health. 2022;10(10):e1423–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larrañeta E, Lutton REM, Woolfson AD, Donnelly RF. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Mater Sci Eng R Rep. 2016;104:1–32.

Article  Google Scholar 

Ramadon D, McCrudden MTC, Courtenay AJ, Donnelly RF. Enhancement strategies for transdermal drug delivery systems: current trends and applications. Drug Deliv Transl Res. 2022;12(4):758–91.

Article  PubMed  Google Scholar 

Andrews SN, Jeong E, Prausnitz MR. Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum. Pharm Res. 2013;30(4):1099–109.

Article  CAS  PubMed  Google Scholar 

Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Adv Drug Deliver Rev. 2012;64(14):1547–68.

Article  CAS  Google Scholar 

Liu T, Chen M, Fu J, Sun Y, Lu C, Quan G, Pan X, Wu C. Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs. Acta Pharm Sin B. 2021;11(8):2326–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kirkby M, Hutton ARJ, Donnelly RF. Microneedle mediated transdermal delivery of protein, peptide and antibody based therapeutics: current status and future considerations. Pharm Res. 2020;37(6):1–18.

Article  Google Scholar 

Waghule T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, Dua K. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomed Pharmacother. 2019;109:1249–58.

Article  CAS  PubMed  Google Scholar 

Gowda A, Healey B, Ezaldein H, Merati M. A systematic review examining the potential adverse effects of microneedling. J Clin Aesthet Dermatol. 2021;14(1):45–54.

PubMed  PubMed Central  Google Scholar 

Lee JW, Park JH, Prausnitz MR. Dissolving microneedles for transdermal drug delivery. Biomaterials. 2008;29(13):2113–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babu MR, Vishwas S, Khursheed R, Harish V, Sravani AB, Khan F, Alotaibi B, Binshaya A, Disouza J, Kumbhar PS, Patravale V, Gupta G, Loebenberg R, Arshad MF, Patel A, Patel S, Dua K, Singh SK. Unravelling the role of microneedles in drug delivery: principle, perspectives, and practices. Drug Deliv Transl Res. 2023. https://doi.org/10.1007/s13346-023-01475-9.

Leone M, Monkare J, Bouwstra JA, Kersten G. Dissolving microneedle patches for dermal vaccination. Pharm Res. 2017;34(11):2223–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rojekar S, Vora LK, Tekko IA, Volpe-Zanutto F, McCarthy HO, Vavia PR, Donnelly RF. Etravirine-loaded dissolving microneedle arrays for long-acting delivery. Eur J Pharm Biopharm. 2021;165:41–51.

Article  CAS  PubMed  Google Scholar 

Li W, Li S, Fan X, Prausnitz MR. Microneedle patch designs to increase dose administered to human subjects. J Control Release. 2021;339:350–60.

Article  CAS  PubMed  Google Scholar 

Prausnitz MR. Microneedles for transdermal drug delivery. Adv Drug Deliv Rev. 2004;56(5):581–7.

Article  CAS  PubMed  Google Scholar 

Jang M, Kang BM, Yang H, Ohn J, Kwon O, Jung H. High-dose steroid dissolving microneedle for relieving atopic dermatitis. Adv Healthc Mater. 2021;10(7):e2001691.

Article  PubMed  Google Scholar 

Li S, Xia D, Prausnitz MR. Efficient drug delivery into skin using a biphasic dissolvable microneedle patch with water-insoluble backing. Adv Funct Mater. 2021;31(44):2103359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez Cuevas MB, Kodani M, Choi Y, Joyce J, O’Connor SM, Kamili S, Prausnitz MR. Hepatitis B vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques. Bioeng Transl Med. 2018;3(3):186–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee IC, Lin W-M, Shu J-C, Tsai S-W, Chen C-H, Tsai M-T. Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice. J Biomed Mater Res, Part A. 2017;105(1):84–93.

Article  CAS  Google Scholar 

Chen J, Qiu Y, Zhang S, Gao Y. Dissolving microneedle-based intradermal delivery of interferon-α-2b. Drug Dev Ind Pharm. 2016;42(6):890–6.

Article  CAS  PubMed  Google Scholar 

McCrudden MT, Alkilani AZ, McCrudden CM, McAlister E, McCarthy HO, Woolfson AD, Donnelly RF. Design and physicochemical characterisation of novel dissolving polymeric microneedle arrays for transdermal delivery of high dose, low molecular weight drugs. J Control Release. 2014;180(100):71–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ripolin A, Quinn J, Larraneta E, Vicente-Perez EM, Barry J, Donnelly RF. Successful application of large microneedle patches by human volunteers. Int J Pharm. 2017;521(1–2):92–101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kathuria H, Li H, Pan J, Lim SH, Kochhar JS, Wu C, Kang L. Large size microneedle patch to deliver lidocaine through skin. Pharm Res. 2016;33(11):2653–67.

Article  CAS  PubMed  Google Scholar 

You J, Yang C, Han J, Wang H, Zhang W, Zhang Y, Lu Z, Wang S, Cai R, Li H, Yu J, Gao J, Zhang Y, Gu Z. Ultrarapid-acting microneedles for immediate delivery of biotherapeutics. Adv Mater. 2023;35(45):e2304582.

Article  PubMed  Google Scholar 

You J, Juhng S, Song J, Park J, Jang M, Kang G, Yang H, Min HS, Shin J, Lee S, Ko HW, Jung H. Egg microneedle for transdermal delivery of active liraglutide. Adv Healthc Mater. 2023;12(9):e2202473.

Article  PubMed  Google Scholar 

Juhng S, Song J, You J, Park J, Yang H, Jang M, Kang G, Shin J, Ko HW, Jung H. Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity. Lab Chip. 2023;23(10):2378–88.

Article  CAS  PubMed  Google Scholar 

Rabiei M, Kashanian S, Bahrami G, Derakhshankhah H, Barzegari E, Samavati SS, McInnes SJP. Dissolving microneedle-assisted long-acting Liraglutide delivery to control type 2 diabetes and obesity. Eur J Pharm Sci. 2021;167(106040):1–9.

Google Scholar 

Aich K, Singh T, Dang S. Advances in microneedle-based transdermal delivery for drugs and peptides. Drug Deliv Transl Res. 2022;12(7):1556–68.

Article  CAS  PubMed  Google Scholar 

Azizoglu E, Ozer O, Prausnitz MR. Fabrication of pure-drug microneedles for delivery of montelukast sodium. Drug Deliv Transl Res. 2022;12(2):444–58.

Article  CAS  PubMed  Google Scholar 

Lee Y, Li W, Tang J, Schwendeman SP, Prausnitz MR. Immediate detachment of microneedles by interfacial fracture for sustained delivery of a contraceptive hormone in the skin. J Control Release. 2021;337:676–85.

Article  CAS  PubMed