da Silva BC, Lyra AC, Rocha R, Santana GO (2014) Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis. World J Gastroenterol 20:9458–9467. https://doi.org/10.3748/wjg.v20.i28.9458

Article  PubMed  PubMed Central  Google Scholar 

Nishida A, Inoue R, Inatomi O, Bamba S, Naito Y, Andoh A (2018) Gut microbiota in the pathogenesis of inflammatory bowel disease. Clin J Gastroenterol 11:1–10. https://doi.org/10.1007/s12328-017-0813-5

Article  PubMed  Google Scholar 

Shen ZH, Zhu CX, Quan YS, Yang ZY, Wu S, Luo WW, Tan B, Wang XY (2018) Relationship between intestinal microbiota and ulcerative colitis: mechanisms and clinical application of probiotics and fecal microbiota transplantation. World J Gastroenterol 24:5–14. https://doi.org/10.3748/wjg.v24.i1.5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Federici S, Kredo-Russo S, Valdés-Mas R, Kviatcovsky D, Weinstock E, Matiuhin Y, Silberberg Y, Atarashi K, Furuichi M, Oka A, Liu B, Fibelman M, Weiner IN, Khabra E, Cullin N, Ben-Yishai N, Inbar D, Ben-David H, Nicenboim J, Kowalsman N, Elinav E (2022) Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation. Cell 185(16):2879-2898.e24. https://doi.org/10.1016/j.cell.2022.07.003

Article  CAS  PubMed  Google Scholar 

Akutko K, Stawarski A (2021) Probiotics, prebiotics and synbiotics in inflammatory bowel diseases. J Clin Med 10(11):2466. https://doi.org/10.3390/jcm10112466

Article  CAS  PubMed  PubMed Central  Google Scholar 

Glassner KL, Abraham BP, Quigley EMM (2020) The microbiome and inflammatory bowel disease. J Allergy Clin Immunol 145:16–27. https://doi.org/10.1016/j.jaci.2019.11.003

Article  CAS  PubMed  Google Scholar 

Shiba T, Aiba Y, Ishikawa H, Ushiyama A, Takagi A, Mine T, Koga Y (2003) The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease. Microbiol Immunol 47:371–378. https://doi.org/10.1111/j.1348-0421.2003.tb03368.x

Article  CAS  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

Article  PubMed  PubMed Central  Google Scholar 

Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 14:135. https://doi.org/10.1186/1471-2288-14-135

Article  PubMed  PubMed Central  Google Scholar 

Luo D, Wan X, Liu J, Tong T (2018) Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res 27:1785–1805. https://doi.org/10.1177/0962280216669183

Article  MathSciNet  PubMed  Google Scholar 

Park SK, Kang SB, Kim S, Kim TO, Cha JM, Im JP, Choi CH, Kim ES, Seo GS, Eun CS (2022) Additive effect of probiotics (Mutaflor) on 5-aminosalicylic acid therapy in patients with ulcerative colitis. Korean J Intern Med 37:949–957. https://doi.org/10.3904/kjim.2021.458

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agraib LM, Yamani MI, Tayyem R, Abu-Sneineh AT, Rayyan YM (2022) Probiotic supplementation induces remission and changes in the immunoglobulins and inflammatory response in active ulcerative colitis patients: a pilot, randomized, double-blind, placebo-controlled study. Clin Nutr ESPEN 51:83–91. https://doi.org/10.1016/j.clnesp.2022.08.020

Article  PubMed  Google Scholar 

Bjarnason I, Sission G, Hayee BH (2019) A randomised, double-blind, placebo-controlled trial of a multi-strain probiotic in patients with asymptomatic ulcerative colitis and Crohn’s disease. Inflammopharmacology 27:465–473. https://doi.org/10.1007/s10787-019-00595-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vejdani R, Bahari A, Zadeh AM, Azmi M, Ebrahimi-Daryani N, Hashtroudi AA, Mehr AJ, Abdollahi M, Sayyah A, Zali MR, Bari Z, Bakhshipour A (2017) Effects of Lactobacillus casei probiotic on mild to moderate ulcerative colitis: a placebo controlled study. Indian J Med Sci 69:24–28

Article  Google Scholar 

Tamaki H, Nakase H, Inoue S, Kawanami C, Itani T, Ohana M, Kusaka T, Uose S, Hisatsune H, Tojo M, Noda T, Arasawa S, Izuta M, Kubo A, Ogawa C, Matsunaka T, Shibatouge M (2016) Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: a randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 28:67–74. https://doi.org/10.1111/den.12553

Article  PubMed  Google Scholar 

Yoshimatsu Y, Yamada A, Furukawa R, Sono K, Osamura A, Nakamura K, Aoki H, Tsuda Y, Hosoe N, Takada N, Suzuki Y (2015) Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis. World J Gastroenterol 21:5985–5994. https://doi.org/10.3748/wjg.v21.i19.5985

Article  PubMed  PubMed Central  Google Scholar 

Petersen AM, Mirsepasi H, Halkjær SI, Mortensen EM, Nordgaard-Lassen I, Krogfelt KA (2014) Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: a double-blind randomized placebo controlled clinical trial. J Crohns Colitis 8:1498–1505. https://doi.org/10.1016/j.crohns.2014.06.001

Article  PubMed  Google Scholar 

Oliva S, Di Nardo G, Ferrari F, Mallardo S, Rossi P, Patrizi G, Cucchiara S, Stronati L (2012) Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis. Aliment Pharmacol Ther 35:327–334. https://doi.org/10.1111/j.1365-2036.2011.04939.x

Article  CAS  PubMed  Google Scholar 

Tursi A, Brandimarte G, Papa A, Giglio A, Elisei W, Giorgetti GM, Forti G, Morini S, Hassan C, Pistoia MA, Modeo ME, Rodino’ S, D’Amico T, Sebkova L, Sacca’ N, Di Giulio E, Luzza F, Imeneo M, Larussa T, Di Rosa S, Annese V, Danese S, Gasbarrini A (2010) Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. Am J Gastroenterol 105:2218–2227. https://doi.org/10.1038/ajg.2010.218

Article  PubMed  PubMed Central  Google Scholar 

Matthes H, Krummenerl T, Giensch M, Wolff C, Schulze J (2010) Clinical trial: probiotic treatment of acute distal ulcerative colitis with rectally administered Escherichia coli Nissle 1917 (EcN). BMC Complem Altern Med 10:13. https://doi.org/10.1186/1472-6882-10-13

Article  Google Scholar 

Sood A, Midha V, Makharia GK, Ahuja V, Singal D, Goswami P, Tandon RK (2009) The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis. Clin Gastroenterol Hepatol 7:1202-1209.e1201. https://doi.org/10.1016/j.cgh.2009.07.016

Article  PubMed  Google Scholar 

Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A (2009) Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol 104:437–443. https://doi.org/10.1038/ajg.2008.118

Article  CAS  PubMed  Google Scholar 

Wildt S, Nordgaard I, Hansen U, Brockmann E, Rumessen JJ (2011) A randomised double-blind placebo-controlled trial with Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp. lactis BB-12 for maintenance of remission in ulcerative colitis. J Crohns Colitis 5:115–121. https://doi.org/10.1016/j.crohns.2010.11.004

Article  PubMed  Google Scholar 

Hirten RP, Sands BE (2021) New therapeutics for ulcerative colitis. Annu Rev Med 72:199–213. https://doi.org/10.1146/annurev-med-052919-120048

Article  CAS  PubMed  Google Scholar 

Derikx LAAP, Dieleman LA, Hoentjen F (2016) Probiotics and prebiotics in ulcerative colitis. Best Pract Res Clin Gastroenterol 30:55–71. https://doi.org/10.1016/j.bpg.2016.02.005

Article  PubMed  Google Scholar 

Štofilová J, Kvaková M, Kamlárová A, Hijová E, Bertková I, Guľašová Z (2022) Probiotic-based intervention in the treatment of ulcerative colitis: conventional and new approaches. Biomedicines 10:2236. https://doi.org/10.3390/biomedicines10092236

Article  CAS  PubMed  PubMed Central  Google Scholar 

Derwa Y, Gracie DJ, Hamlin PJ, Ford AC (2017) Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease. Aliment Pharmacol Ther 46(4):389–400. https://doi.org/10.1111/apt.14203

Article  CAS  PubMed  Google Scholar 

Ganji-Arjenaki M, Rafieian-Kopaei M (2018) Probiotics are a good choice in remission of inflammatory bowel diseases: a meta analysis and systematic review. J Cell Physiol 233(3):2091–2103. https://doi.org/10.1002/jcp.25911

Article  CAS  PubMed  Google Scholar 

Cristofori F, Dargenio VN, Dargenio C, Miniello VL, Barone M, Francavilla R (2021) Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body. Front Immunol 12:578386. https://doi.org/10.3389/fimmu.2021.578386

Article  CAS  PubMed  PubMed Central  Google Scholar 

Celiberto LS, Bedani R, Rossi EA, Cavallini DC (2017) Probiotics: The scientific evidence in the context of inflammatory bowel disease. Crit Rev Food Sci Nutr 57(9):1759–1768. https://doi.org/10.1080/10408398.2014.941457

Article  CAS  PubMed  Google Scholar 

Roy S, Dhaneshwar S (2023) Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives. World J Gastroenterol 29(14):2078–2100. https://doi.org/10.3748/wjg.v29.i14.2078

Article  CAS  PubMed