Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

Dhanya Ramachandran, Tjoung-Won Park-Simon, Peter Schürmann, Lisa-Marie Speith, Peter Hillemanns & Thilo Dörk

Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK

Jonathan P. Tyrer & Paul D. P. Pharoah

Department of Women’s Health, Tuebingen University Hospital, Tuebingen, Germany

Stefan Kommoss

Centre for Cancer Research, The Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia

Anna DeFazio

Discipline of Obstetrics and Gynaecology, The University of Sydney, Sydney, NSW, Australia

Anna DeFazio

Department of Gynaecological Oncology, Westmead Hospital, Sydney, NSW, Australia

Anna DeFazio & Alison Brand

The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, NSW, Australia

Anna DeFazio

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Durham, NC, USA

Marjorie J. Riggan & Andrew Berchuck

Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

David Bowtell, Sian Fereday, Nadia Traficante & Peter Grant

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

Jillian Hung

Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

Penelope M. Webb, Andreas Obermair, Vanessa Beesley, Penelope Blomfield, Alison Davis, Yee Leung, James Nicklin, Michael Quinn, Karen Livingstone, Helen O’Neill & Merran Williams

Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Erlangen, Germany

Peter A. Fasching

Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium

Diether Lambrechts

VIB Center for Cancer Biology, VIB, Leuven, Belgium

Diether Lambrechts

Biochemistry and Molecular Biology area, Department of Basic Health Sciences, Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain

María J. García

Hereditary Endocrine Cancer Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain

Cristina Rodríguez-Antona

Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain

Cristina Rodríguez-Antona

Cancer Prevention and Control Program, Cedars-Sinai Cancer, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Marc T. Goodman

Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA

Francesmary Modugno

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Francesmary Modugno

Women’s Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, PA, USA

Francesmary Modugno

Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA

Kirsten B. Moysich

David Geffen School of Medicine, Department of Obstetrics and Gynecology, University of California at Los Angeles, Los Angeles, CA, USA

Beth Y. Karlan & Jenny Lester

Department of Virus, Lifestyle and Genes, Danish Cancer Institute, Copenhagen, Denmark

Susanne K. Kjaer & Allan Jensen

Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Susanne K. Kjaer & Claus K. Høgdall

Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark

Estrid Høgdall

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA

Ellen L. Goode

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mayo Clinic, Rochester, MN, USA

William A. Cliby & Amanika Kumar

Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA

Chen Wang & Stacey J. Winham

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

Julie M. Cunningham

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA

Alvaro N. Monteiro

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA

Joellen M. Schildkraut

Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gyneclogy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

Daniel W. Cramer & Kathryn L. Terry

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

Daniel W. Cramer & Kathryn L. Terry

Norris Cotton Cancer Center, Lebanon, NH, USA

Linda Titus

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway

Line Bjorge & Liv Cecilie Vestrheim Thomsen

Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway

Line Bjorge & Liv Cecilie Vestrheim Thomsen

School of Clinical Medicine, UNSW Medicine and Health, University of NSW Sydney, Sydney, NSW, Australia

Michael Friedlander & Susan J. Ramus

Department of ObGyn, Providence Medical Center, Medford, OR, USA

Tanja Pejovic

Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA

Tanja Pejovic

Division of Cancer and Ovarian Cancer Action Research Centre, Department Surgery & Cancer, Imperial College London, London, UK

Iain A. McNeish

Institute of Cancer Sciences, University of Glasgow, Glasgow, UK

Iain A. McNeish

Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada

Taymaa May

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada

David G. Huntsman

Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, BC, Canada

David G. Huntsman

Gynecologic Oncology Center, Kiel, Germany

Jacobus Pfisterer

University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

Ulrich Canzler

National Center for Tumor Diseases (NCT), Partner Site Dresden, Dresden, Germany

Ulrich Canzler

Klinikum Bremen-Mitte, Bremen, Germany

Willibald Schröder

Gynaekologicum Bremen, Bremen, Germany

Willibald Schröder

University Hospital Greifswald, Greifswald, Germany

Antje Belau

Frauenarztpraxis Belau, Greifswald, Germany

Antje Belau

University Hospital Frankfurt, Frankfurt, Germany

Lars Hanker

University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

Lars Hanker

Department of Gynecology and Gynecologic Oncology, Evangelische Kliniken Essen-Mitte (KEM), Essen, Germany

Philipp Harter & Florian Heitz

Charité - Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany

Jalid Sehouli & Florian Heitz

University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Rainer Kimmig

University Hospital Ulm, Ulm, Germany

Nikolaus de Gregorio

SLK-Kliniken Heilbronn, Klinikum am Gesundbrunnen, Heilbronn, Germany

Nikolaus de Gregorio

University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Barbara Schmalfeldt

University Hospital Gießen and Marburg, Site Marburg, Marburg, Germany

Klaus Baumann

Klinikum Ludwigshafen, Ludwigshafen, Germany

Klaus Baumann

University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Felix Hilpert

Krankenhaus Jerusalem, Mammazentrum Hamburg, Hamburg, Germany

Felix Hilpert

University Hospital LMU Munich, Munich, Germany

Alexander Burges

Department of Obstetrics, Gynecology and Women’s Health, Division of Gynecologic Oncology, University of Minnesota, Minneapolis, MN, USA

Boris Winterhoff

Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

Sharon E. Johnatty & Georgia Chenevix-Trench

Adult Cancer Program, Lowy Cancer Research Centre, University of NSW Sydney, Sydney, NSW, Australia

Susan J. Ramus

Department of Computational Biomedicine, Cedars-Sinai Medical Center, West Hollywood, CA, USA

Paul D. P. Pharoah

Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

Paul D. P. Pharoah

Department of Gynecology and Gynecological Oncology, HSK, Dr. Horst-Schmidt Klinik, Wiesbaden, Wiesbaden, Germany

Florian Heitz

The study was conceptualised by F.H., T.D., P.D.P., G.C-T., S.J.R., and A.B. GWAS analysis was performed by J.P.T. Further genotyping, data analysis and post-GWAS analysis were performed by D.R., P.Sc., and L-M.Spei. RNA sequencing and methylation data were generated by S.Ko., B.Wi. and J.Pf. OCAC database was maintained and coordinated by M.J.R. Authors on behalf of OCAC contributed samples and clinical data to OCAC. Authors on behalf of the AGO contributed samples and clinical data to the AGO-OVAR 11 study. The manuscript was drafted by D.R., F.H. and T.D., with critical input from members of the writing group (J.T., A.DF., M.J.R., A.B., P.D.P, G.C-T., S.J.R.). All authors were involved in the further editing of the manuscript and agreed with this version of the manuscript.