Berthelot JM, Le Goff B. Rheumatoid arthritis and periodontal disease. Joint Bone Spine. 2010;77(6):537–41.
Article CAS PubMed Google Scholar
de Pablo P, Chapple IL, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol. 2009;5(4):218–24.
Firatli E, Kantarci A, Cebeci I, Tanyeri H, Sonmez G, Carin M, Tuncer O. Association between HLA antigens and early onset periodontitis. J Clin Periodontol. 1996;23(6):563–6.
Article CAS PubMed Google Scholar
Bingham CO 3rd, Moni M. Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions. Curr Opin Rheumatol. 2013;25(3):345–53.
Article CAS PubMed PubMed Central Google Scholar
Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet. 2012;44(3):291–6.
Article CAS PubMed PubMed Central Google Scholar
Delima AJ, Van Dyke TE. Origin and function of the cellular components in gingival crevice fluid. Periodontol. 2000;2003(31):55–76.
Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532–5.
Article ADS CAS PubMed Google Scholar
• Wigerblad G, Kaplan MJ. Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. Nat Rev Immunol. 2023;23(5):274–88. Here, authors summarize the latest role of NETs in autoimmune and inflammatory conditions.
Article CAS PubMed Google Scholar
Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GM, van Veelen PA, et al. Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci U S A. 2011;108(42):17372–7.
Article ADS CAS PubMed PubMed Central Google Scholar
Carmona-Rivera C, Carlucci PM, Moore E, Lingampalli N, Uchtenhagen H, James E, et al. Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis. Sci Immunol. 2017;2(10):eaag3358.
• O’Neil LJ, Barrera-Vargas A, Sandoval-Heglund D, Merayo-Chalico J, Aguirre-Aguilar E, Aponte AM, et al. Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis. Sci Adv. 2020;6(44):eabd2688. This paper found novel antibodies against carbamylated proteins in RA patients that correlate with bone erosion and potentiate osteoclast formation.
Scott DL. Radiological progression in established rheumatoid arthritis. J Rheumatol Suppl. 2004;69:55–65.
Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998;152(4):943–51.
CAS PubMed PubMed Central Google Scholar
Hienz SA, Paliwal S, Ivanovski S. Mechanisms of bone resorption in periodontitis. J Immunol Res. 2015;2015: 615486.
Article PubMed PubMed Central Google Scholar
Soysa NS, Alles N, Aoki K, Ohya K. Osteoclast formation and differentiation: an overview. J Med Dent Sci. 2012;59(3):65–74.
Malmstrom V, Catrina AI, Klareskog L. Author correction: The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting. Nat Rev Immunol. 2022;22(7):459.
Fugger L, Svejgaard A. Association of MHC and rheumatoid arthritis HLA-DR4 and rheumatoid arthritis: studies in mice and men. Arthritis Res. 2000;2(3):208–11.
Article CAS PubMed PubMed Central Google Scholar
Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts Periodontol 2000. 2013;62(1):203–17.
Mikuls TR, Payne JB, Yu F, Thiele GM, Reynolds RJ, Cannon GW, et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol. 2014;66(5):1090–100.
Article PubMed PubMed Central Google Scholar
Marotte H, Farge P, Gaudin P, Alexandre C, Mougin B, Miossec P. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Ann Rheum Dis. 2006;65(7):905–9.
Article CAS PubMed Google Scholar
Bialowas K, Radwan-Oczko M, Dus-Ilnicka I, Korman L, Swierkot J. Periodontal disease and influence of periodontal treatment on disease activity in patients with rheumatoid arthritis and spondyloarthritis. Rheumatol Int. 2020;40(3):455–63.
Article CAS PubMed Google Scholar
Gomez-Banuelos E, Mukherjee A, Darrah E, Andrade F. Rheumatoid arthritis-associated mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. J Clin Med. 2019;8(9).
Wegner N, Wait R, Sroka A, Eick S, Nguyen KA, Lundberg K, et al. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 2010;62(9):2662–72.
Article CAS PubMed PubMed Central Google Scholar
Rosenstein ED, Weissmann G, Greenwald RA. Porphyromonas gingivalis, periodontitis and rheumatoid arthritis. Med Hypotheses. 2009;73(3):457–8.
Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, et al. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol. 2009;9(1):38–42.
Article CAS PubMed Google Scholar
Johansson L, Sherina N, Kharlamova N, Potempa B, Larsson B, Israelsson L, et al. Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis. Arthritis Res Ther. 2016;18(1):201.
Article PubMed PubMed Central Google Scholar
Sherina N, de Vries C, Kharlamova N, Sippl N, Jiang X, Brynedal B, et al. Antibodies to a citrullinated Porphyromonas gingivalis epitope are increased in early rheumatoid arthritis, and can be produced by gingival tissue B Cells: Implications for a Bacterial Origin in RA Etiology. Front Immunol. 2022;13: 804822.
Article CAS PubMed PubMed Central Google Scholar
Brewer RC, Lanz TV, Hale CR, Sepich-Poore GD, Martino C, Swafford AD, et al. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. Sci Transl Med. 2023;15(684):eabq8476.
Article CAS PubMed PubMed Central Google Scholar
Amarasekara DS, Yu J, Rho J. Bone loss triggered by the cytokine network in inflammatory autoimmune diseases. J Immunol Res. 2015;2015: 832127.
Article PubMed PubMed Central Google Scholar
Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, et al. Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis. Nat Med. 2009;15(4):417–24.
Article CAS PubMed Google Scholar
Kennedy A, Fearon U, Veale DJ, Godson C. Macrophages in synovial inflammation Front Immunol. 2011;2:52.
Yu T, Zhao L, Huang X, Ma C, Wang Y, Zhang J, Xuan D. Enhanced activity of the macrophage M1/M2 phenotypes and phenotypic switch to M1 in periodontal infection. J Periodontol. 2016;87(9):1092–102.
Article CAS PubMed Google Scholar
Papadopoulos G, Weinberg EO, Massari P, Gibson FC 3rd, Wetzler LM, Morgan EF, Genco CA. Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. J Immunol. 2013;190(3):1148–57.
Article CAS PubMed Google Scholar
Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 2000;106(12):1481–8.
Article CAS PubMed PubMed Central Google Scholar
Feng X, Shi Y, Xu L, Peng Q, Wang F, Wang X, et al. Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5. Sci Rep. 2016;6:32001.
Article ADS CAS PubMed PubMed Central Google Scholar
Wu Q, Zhou X, Huang D, Ji Y, Kang F. IL-6 enhances osteocyte-mediated osteoclastogenesis by promoting JAK2 and RANKL activity in vitro. Cell Physiol Biochem. 2017;41(4):1360–9.
Article CAS PubMed Google Scholar
Otsuka Y, Kondo T, Aoki H, Goto Y, Kawaguchi Y, Waguri-Nagaya Y, et al. IL-1beta promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells. J Pharmacol Sci. 2023;151(1):1–8.
Article CAS PubMed Google Scholar
Sima C, Glogauer M. Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone. Periodontol 2000. 2013;63(1):80–101.
Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL. IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest. 2005;115(2):282–90.
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