Zheng MZM, Wakim LM (2022) Tissue resident memory T cells in the respiratory tract. Mucosal Immunol 15(3):379–88. https://doi.org/10.1038/s41385-021-00461-z

Article  CAS  PubMed  Google Scholar 

Lange J, Rivera-Ballesteros O, Buggert M (2022) Human mucosal tissue-resident memory T cells in health and disease. Mucosal Immunol 15(3):389–97. https://doi.org/10.1038/s41385-021-00467-7

Article  CAS  PubMed  Google Scholar 

Hasan MH, Beura LK (2022) Cellular interactions in resident memory T cell establishment and function. Curr Opin Immunol 74:68–75. https://doi.org/10.1016/j.coi.2021.10.005

Article  CAS  PubMed  Google Scholar 

Barros L, Ferreira C, Veldhoen M (2022) The fellowship of regulatory and tissue-resident memory cells. Mucosal Immunol 15(1):64–73. https://doi.org/10.1038/s41385-021-00456-w

Article  CAS  PubMed  Google Scholar 

Tang X, Rabin RL, Yan L (2021) A three-stage design for allergen immunotherapy trials. Allergy. https://doi.org/10.1111/all.15117

Article  PubMed  Google Scholar 

Murrison LB, Brandt EB, Myers JB, Hershey GKK (2019) Environmental exposures and mechanisms in allergy and asthma development. J Clin Invest 129(4):1504–15. https://doi.org/10.1172/jci124612

Article  PubMed  PubMed Central  Google Scholar 

Ji H, Hu Y, Zhang T, Wang Y, Shen L, Wang S, Chen M, Wei M, Yu G (2019) Allergic comorbidity of asthma or wheezing, allergic rhinitis, and eczema: result from 333 029 allergic children in Shanghai, China. Am J Rhinol Allergy 34(2):189–195. https://doi.org/10.1177/1945892419883238

Wakim LM, Woodward-Davis A, Liu R, Hu Y, Villadangos JA, Smyth GK, Bevan MJ (2012) The molecular signature of tissue resident memory CD8 T cells isolated from the brain. J Immunol. https://doi.org/10.4049/jimmunol.1201305

Article  PubMed  Google Scholar 

Schenkel JM, Fraser K, Beura LK, Pauken KE, Vezys V, Masopust D (2014) Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science. https://doi.org/10.1126/science.1254536

Article  PubMed  PubMed Central  Google Scholar 

Grau-Expósito J, Sánchez-Gaona N, Massana N, Suppi M, Astorga-Gamaza A, Perea D, Rosado J, Falcó A, Kirkegaard C, Torrella A, Planas B, Navarro J, Suanzes P, Álvarez-Sierra D, Ayora A, Sansano I, Esperalba J, Andrés C, Antón A, Cajal SRy, Almirante B, Pujol-Borrell R, Falcó V, Burgos J, Buzón MJ, Genescà M (2021) Peripheral and lung resident memory T cell responses against SARS-CoV-2. Nat Commun. https://doi.org/10.1038/s41467-021-23333-3

Article  PubMed  PubMed Central  Google Scholar 

Gálvez-Cancino F, López E, Menares E, Díaz X, Flores C, Cáceres P, Hidalgo S, Chovar O, Alcántara-Hernández M, Borgna V, Varas-Godoy M, Salazar-Onfray F, Idoyaga J, Lladser Á (2018) Vaccination-induced skin-resident memory CD8+T cells mediate strong protection against cutaneous melanoma. Oncoimmunology. https://doi.org/10.1080/2162402x.2018.1442163

Article  PubMed  PubMed Central  Google Scholar 

Emmanuel T, Mistegård J, Bregnhøj A, Johansen C, Iversen L (2021) Tissue-resident memory T cells in skin diseases: a systematic review. Int J Mol Sci. https://doi.org/10.3390/ijms22169004

Article  PubMed  PubMed Central  Google Scholar 

Glennie ND, Yeramilli VA, Beiting DP, Volk SW, Weaver CT, Scott P (2015) Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection. J Exp Med 212(9):1405–14

Article  CAS  PubMed  PubMed Central  Google Scholar 

Slütter B, Van Braeckel-Budimir N, Abboud G, Varga SM, Salek-Ardakani S, Harty JT (2017) Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity. Sci Immunol 2(7):eaag2031. https://doi.org/10.1126/sciimmunol.aag2031

Masopust D, Choo D, Vezys V, Wherry EJ, Duraiswamy J, Akondy R, Wang J, Casey KA, Barber DL, Kawamura KS (2010) Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med 207(3):553–64

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teijaro JR, Turner D, Pham Q, Wherry EJ, Lefrançois L, Farber DL (2011) Cutting edge: tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J Immunol 187(11):5510–5514. https://doi.org/10.4049/jimmunol.1102243

Fu J, Sykes M (2022) Emerging concepts of tissue-resident memory T cells in transplantation. Transplantation 106(6):1132–1142. https://doi.org/10.1097/tp.0000000000004000

Enamorado M, Khouili SC, Iborra S, Sancho D (2018) Genealogy, dendritic cell priming, and differentiation of tissue-resident memory CD8+ T cells. Front Immunol. https://doi.org/10.3389/fimmu.2018.01751

Article  PubMed  PubMed Central  Google Scholar 

Stein JV, Ruef N, Wissmann S (2021) Organ-specific surveillance and long-term residency strategies adapted by tissue-resident memory CD8+ T cells. Front Immunol. https://doi.org/10.3389/fimmu.2021.626019

Article  PubMed  PubMed Central  Google Scholar 

Mueller SN, Mackay LK (2015) Tissue-resident memory T cells: local specialists in immune defence. Nat Rev Immunol. https://doi.org/10.1038/nri.2015.3

Article  PubMed  Google Scholar 

Leggat JA, Gibbons DL, Haque SF, Smith AL, Wells JW, Choy K, Lloyd CM, Hayday AC, Noble A (2008) Innate responsiveness of CD8 memory T-cell populations nonspecifically inhibits allergic sensitization. J Allergy Clin Immunol 122(5):1014–1021.e4. https://doi.org/10.1016/j.jaci.2008.08.011

Cheroutre H, Madakamutil L (2005) Mucosal effector memory T cells: the other side of the coin. Cell Mol Life Sci 62(23):2853–66. https://doi.org/10.1007/s00018-005-5232-y

Article  CAS  PubMed  Google Scholar 

Dijkgraaf FE, Kok L, Schumacher TNM (2021) Formation of tissue-resident CD8+ T-cell memory. Cold Spring Harb Perspect Biol 13(8): a038117. https://doi.org/10.1101/cshperspect.a038117

Walsh DA, Borges da Silva H, Beura LK, Peng C, Hamilton SE, Masopust D, Jameson SC (2019) The functional requirement for CD69 in establishment of resident memory CD8(+) T cells varies with tissue location. J Immunol 203(4):946–55. https://doi.org/10.4049/jimmunol.1900052

Article  CAS  PubMed  Google Scholar 

Turner DL, Goldklang M, Cvetkovski F, Paik D, Trischler J, Barahona J, Cao M, Dave R, Tanna N, D’Armiento JM, Farber DL (2018) Biased generation and in situ activation of lung tissue-resident memory CD4 T cells in the pathogenesis of allergic asthma. J Immunol 200(5):1561–9. https://doi.org/10.4049/jimmunol.1700257

Article  CAS  PubMed  Google Scholar 

Hondowicz BD, An D, Schenkel JM, Kim KS, Steach HR, Krishnamurty AT, Keitany GJ, Garza EN, Fraser KA, Moon JJ, Altemeier WA, Masopust D, Pepper M (2016) Interleukin-2-dependent allergen-specific tissue-resident memory cells drive asthma. Immunity 44(1):155–66. https://doi.org/10.1016/j.immuni.2015.11.004

Article  CAS  PubMed  Google Scholar 

Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM (2016) A tissue checkpoint regulates type 2 immunity. Nat Immunol 17(12):1381–7. https://doi.org/10.1038/ni.3582

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masopust D, Soerens AG (2019) Tissue-resident T cells and other resident leukocytes. Annu Rev Immunol. https://doi.org/10.1146/annurev-immunol-042617-053214

Article  PubMed  PubMed Central  Google Scholar 

Jha P, Das H (2017) KLF2 in regulation of NF-κB-mediated immune cell function and inflammation. Int J Mol Sci. https://doi.org/10.3390/ijms18112383

Article  PubMed  PubMed Central  Google Scholar 

Zhong F, Lee KH, He JC (2018) Role of Krüppel-like factor-2 in kidney disease. Nephrology. https://doi.org/10.1111/nep.13456

Article  PubMed  PubMed Central  Google Scholar 

Pernaa N, Keskitalo S, Chowdhury I, Nissinen A, Glumoff V, Keski-Filppula R, Junttila J, Eklund KK, Santaniemi W, Siitonen S, Seppänen MRJ, Vähäsalo P, Varjosalo M, Åström P, Hautala T (2022) Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity. Front Immunol. https://doi.org/10.3389/fimmu.2022.819929

Article  PubMed  PubMed Central  Google Scholar 

Szabo PA, Miron M, Farber DL (2019) Location, location, location: Tissue resident memory T cells in mice and humans. Sci Immunol 4(34):eaas9673. https://doi.org/10.1126/sciimmunol.aas9673

Fung HY, Teryek M, Lemenze AD, Bergsbaken T (2022) CD103 fate mapping reveals that intestinal CD103- tissue-resident memory T cells are the primary responders to secondary infection. Sci Immunol 7(77):eabl9925. https://doi.org/10.1126/sciimmunol.abl9925

Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS (2006) A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol 126(5):1059–70. https://doi.org/10.1038/sj.jid.5700199

Article  CAS  PubMed  Google Scholar 

Cheuk S, Schlums H, Sérézal IG, Martini E, Chiang SCC, Marquardt N, Gibbs A, Detlofsson E, Introini A, Forkel M, Höög C, Tjernlund A, Michaëlsson J, Folkersen L, Mjösberg J, Blomqvist L, Ehrström M, Ståhle M, Bryceson YT, Eidsmo L (2017) CD49a expression defines tissue-resident CD8+ T cells poised for cytotoxic function in human skin. Immunity 46(2):287–300. https://doi.org/10.1016/j.immuni.2017.01.009

Samat AAK, Geest Jvd, Vastert SJ, Loosdregt Jv, Wijk Fv (2021) Tissue-resident memory T cells in chronic inflammation-local cells with systemic effects? Cells 10(2):409. https://doi.org/10.3390/cells10020409

Schlickum S, Sennefelder H, Friedrich M, Harms GS, Lohse MJ, Kilshaw PJ, Schön MP (2008) Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a ligand-dependent fashion. Blood 112(3):619–625. https://doi.org/10.1182/blood-2008-01-134833

Floc’h AL, Jalil A, Vergnon I, Chansac BLM, Lazar V, Bismuth G, Chouaı̈b S, Mami‐Chouaib F (2007) αEβ7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis. J Exp Med 204(3):559–570. https://doi.org/10.1084/jem.20061524

Drouillard A, Neyra A, Mathieu A, Marçais A, Wencker M, Marvel J, Belot A, Walzer T (2018) Human naive and memory T cells display opposite migratory responses to sphingosine-1 phosphate. J Immunol 200(2):551–557. https://doi.org/10.4049/jimmunol.1701278

Campbell JJ, Murphy K, Kunkel EJ, Brightling CE, Soler D, Shen Z, Boisvert J, Greenberg HB, Vierra MA, Goodman SB, Genovese MC, Wardlaw AJ, Butcher EC, Wu L (2001) CCR7 expression and memory T cell diversity in humans. J Immunol 166(2):877–884. https://doi.org/10.4049/jimmunol.166.2.877

Parga-Vidal L, Taggenbrock R, Beumer-Chuwonpad A, Aglmous H, Kragten NAM, Behr FM, Bovens A, Lier RAWv, Stark R, Gisbergen KPJMv (2022) Hobit and Blimp-1 regulate TRM abundance after LCMV infection by suppressing tissue exit pathways of TRM precursors. Eur J Immunol 52(7):1095–1111. https://doi.org/10.1002/eji.202149665

Khan TN, Mooster JL, Kilgore AM, Osborn JF, Nolz JC (2016) Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection. J Exp Med 213(6):951–66. https://doi.org/10.1084/jem.20151855

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL (2002) CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature. 420(6915):502–7. https://doi.org/10.1038/nature01152

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