Mill, P., Christensen, S. T. & Pedersen, L. B. Primary cilia as dynamic and diverse signalling hubs in development and disease. Nat. Rev. Genet. 24, 421–441 (2023).
Article CAS PubMed PubMed Central Google Scholar
Hilgendorf, K. I., Johnson, C. T. & Jackson, P. K. The primary cilium as a cellular receiver: organizing ciliary GPCR signaling. Curr. Opin. Cell Biol. 39, 84–92 (2016).
Article CAS PubMed PubMed Central Google Scholar
Hilgendorf, K. I. Primary cilia are critical regulators of white adipose tissue expansion. Front. Physiol. 12, 769367 (2021).
Article PubMed PubMed Central Google Scholar
Wachten, D. & Mick, D. U. Signal transduction in primary cilia — analyzing and manipulating GPCR and second messenger signaling. Pharmacol. Ther. 224, 107836 (2021).
Article CAS PubMed Google Scholar
Zhang, Y. & Beachy, P. A. Cellular and molecular mechanisms of Hedgehog signalling. Nat. Rev. Mol. Cell Biol. 24, 668–687 (2023).
Article CAS PubMed Google Scholar
Gigante, E. D. & Caspary, T. Signaling in the primary cilium through the lens of the Hedgehog pathway. Wiley Interdiscip. Rev. Dev. Biol. 9, e377 (2020).
Article PubMed PubMed Central Google Scholar
Kong, J. H., Siebold, C. & Rohatgi, R. Biochemical mechanisms of vertebrate hedgehog signaling. Development 146, dev166892 (2019).
Article CAS PubMed PubMed Central Google Scholar
Esarte Palomero, O., Larmore, M. & DeCaen, P. G. Polycystin channel complexes. Annu. Rev. Physiol. 85, 425–448 (2023).
Article CAS PubMed Google Scholar
Pazour, G. J., Quarmby, L., Smith, A. O., Desai, P. B. & Schmidts, M. Cilia in cystic kidney and other diseases. Cell Signal. 69, 109519 (2020).
Derderian, C., Canales, G. I. & Reiter, J. F. Seriously cilia: a tiny organelle illuminates evolution, disease, and intercellular communication. Dev. Cell 58, 1333–1349 (2023).
Article CAS PubMed Google Scholar
Reiter, J. F. & Leroux, M. R. Genes and molecular pathways underpinning ciliopathies. Nat. Rev. Mol. Cell Biol. 18, 533–547 (2017).
Article CAS PubMed PubMed Central Google Scholar
Wallmeier, J. et al. Motile ciliopathies. Nat. Rev. Dis. Prim. 6, 77 (2020).
Breslow, D. K. & Holland, A. J. Mechanism and regulation of centriole and cilium biogenesis. Annu. Rev. Biochem. 88, 691–724 (2019).
Article CAS PubMed PubMed Central Google Scholar
Prosser, S. L. & Pelletier, L. Mitotic spindle assembly in animal cells: a fine balancing act. Nat. Rev. Mol. Cell Biol. 18, 187–201 (2017).
Article CAS PubMed Google Scholar
Carvalho-Santos, Z., Azimzadeh, J., Pereira-Leal, J. B. & Bettencourt-Dias, M. Evolution: tracing the origins of centrioles, cilia, and flagella. J. Cell Biol. 194, 165–175 (2011).
Article CAS PubMed PubMed Central Google Scholar
Serwas, D., Su, T. Y., Roessler, M., Wang, S. & Dammermann, A. Centrioles initiate cilia assembly but are dispensable for maturation and maintenance in C. elegans. J. Cell Biol. 216, 1659–1671 (2017).
Article CAS PubMed PubMed Central Google Scholar
Satir, P., Pedersen, L. B. & Christensen, S. T. The primary cilium at a glance. J. Cell Sci. 123, 499–503 (2010).
Article CAS PubMed PubMed Central Google Scholar
Kiesel, P. et al. The molecular structure of mammalian primary cilia revealed by cryo-electron tomography. Nat. Struct. Mol. Biol. 27, 1115–1124 (2020).
Article CAS PubMed PubMed Central Google Scholar
Polino, A. J., Sviben, S., Melena, I., Piston, D. W. & Hughes, J. W. Scanning electron microscopy of human islet cilia. Proc. Natl Acad. Sci. USA 120, e2302624120 (2023).
Article CAS PubMed PubMed Central Google Scholar
Sun, S., Fisher, R. L., Bowser, S. S., Pentecost, B. T. & Sui, H. Three-dimensional architecture of epithelial primary cilia. Proc. Natl Acad. Sci. USA 116, 9370–9379 (2019).
Article CAS PubMed PubMed Central Google Scholar
Wang, W. et al. Intraflagellar transport proteins as regulators of primary cilia length. Front. Cell Dev. Biol. 9, 661350 (2021).
Article PubMed PubMed Central Google Scholar
Plotnikova, O. V., Pugacheva, E. N. & Golemis, E. A. Primary cilia and the cell cycle. Methods Cell Biol. 94, 137–160 (2009).
Article CAS PubMed PubMed Central Google Scholar
Nachury, M. V. & Mick, D. U. Establishing and regulating the composition of cilia for signal transduction. Nat. Rev. Mol. Cell Biol. 20, 389–405 (2019).
Article CAS PubMed PubMed Central Google Scholar
Zhang, Z. et al. Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography. Life Sci. Alliance 7, e202302409 (2023).
Horst, C. J., Forestner, D. M. & Besharse, J. C. Cytoskeletal–membrane interactions: a stable interaction between cell surface glycoconjugates and doublet microtubules of the photoreceptor connecting cilium. J. Cell Biol. 105, 2973–2987 (1987).
Article CAS PubMed Google Scholar
Sang, L. et al. Mapping the NPHP–JBTS–MKS protein network reveals ciliopathy disease genes and pathways. Cell 145, 513–528 (2011).
Article CAS PubMed PubMed Central Google Scholar
Garcia, G., Raleigh, D. R. & Reiter, J. F. How the ciliary membrane is organized inside-out to communicate outside-in. Curr. Biol. 28, R421–R434 (2018).
Article CAS PubMed PubMed Central Google Scholar
Ghossoub, R., Molla-Herman, A., Bastin, P. & Benmerah, A. The ciliary pocket: a once-forgotten membrane domain at the base of cilia. Biol. Cell 103, 131–144 (2011).
Molla-Herman, A. et al. The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia. J. Cell Sci. 123, 1785–1795 (2010).
Article CAS PubMed Google Scholar
Han, S. et al. TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia. Biochem. Biophys. Res. Commun. 509, 227–234 (2019).
Article CAS PubMed Google Scholar
Conduit, S. E. & Vanhaesebroeck, B. Phosphoinositide lipids in primary cilia biology. Biochem. J. 477, 3541–3565 (2020).
Article CAS PubMed Google Scholar
Chávez, M. et al. Modulation of ciliary phosphoinositide content regulates trafficking and Sonic hedgehog signaling output. Dev. Cell 34, 338–350 (2015).
Garcia-Gonzalo, F. R. et al. Phosphoinositides regulate ciliary protein trafficking to modulate Hedgehog signaling. Dev. Cell 34, 400–409 (2015).
Article CAS PubMed PubMed Central Google Scholar
Conduit, S. E., Davies, E. M., Fulcher, A. J., Oorschot, V. & Mitchell, C. A. Superresolution microscopy reveals distinct phosphoinositide subdomains within the cilia transition zone. Front. Cell Dev. Biol. 9, 634649 (2021).
Article PubMed PubMed Central Google Scholar
Krajnik, A. et al. Phosphoinositide signaling and mechanotransduction in cardiovascular biology and disease. Front. Cell Dev. Biol. 8, 595849 (2020).
Article PubMed PubMed Central Google Scholar
Kinnebrew, M. et al. Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. eLife 8, e50051 (2019).
Article PubMed PubMed Central Google Scholar
Breslow, D. K., Koslover, E. F., Seydel, F., Spakowitz, A. J. & Nachury, M. V. An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier. J. Cell Biol. 203, 129–147 (2013).
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