Dixon, S. J. et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149, 1060–1072 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galy, B., Conrad, M. & Muckenthaler, M. Mechanisms controlling cellular and systemic iron homeostasis.Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-023-00648-1 (2023).

Article  PubMed  Google Scholar 

Conrad, M. & Pratt, D. A. The chemical basis of ferroptosis. Nat. Chem. Biol. 15, 1137–1147 (2019).

Article  CAS  PubMed  Google Scholar 

Ursini, F. & Maiorino, M. Lipid peroxidation and ferroptosis: the role of GSH and GPx4. Free Radic. Biol. Med. 152, 175–185 (2020).

Article  CAS  PubMed  Google Scholar 

Conrad, M. et al. Regulation of lipid peroxidation and ferroptosis in diverse species. Genes Dev. 32, 602–619 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, L. et al. Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520, 57–62 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Y. et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat. Cell Biol. 20, 1181–1192 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stockwell, B. R. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 185, 2401–2421 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirata, Y. et al. Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.Curr. Biol. 33, 1282–1294.e5 (2023).

Article  CAS  PubMed  Google Scholar 

Dixon, S. J. & Pratt, D. A. Ferroptosis: a flexible constellation of related biochemical mechanisms. Mol. Cell 83, 1030–1042 (2023).

Article  CAS  PubMed  Google Scholar 

Green, D. R. The coming decade of cell death research: five riddles. Cell 177, 1094–1107 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kayagaki, N. et al. NINJ1 mediates plasma membrane rupture during lytic cell death. Nature 591, 131–136 (2021).

Article  CAS  PubMed  Google Scholar 

Dondelinger, Y. et al. NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis. Cell Death Dis. 14, 755 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pope, L. E. & Dixon, S. J. Regulation of ferroptosis by lipid metabolism. Trends Cell Biol. 33, 1077–1087 (2023).

Article  CAS  PubMed  Google Scholar 

Liang, D., Minikes, A. M. & Jiang, X. Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol. Cell 82, 2215–2227 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, Z., Lange, M., Dixon, S. J. & Olzmann, J. A. Lipid quality control and ferroptosis: from concept to mechanism. Annu. Rev. Biochem. https://doi.org/10.1146/annurev-biochem-052521-033527 (2023).

Article  PubMed  Google Scholar 

Wenzel, S. E. et al. PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals. Cell 171, 628–641.e6 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shah, R., Shchepinov, M. S. & Pratt, D. A. Resolving the role of lipoxygenases in the initiation and execution of ferroptosis. ACS Cent. Sci. 4, 387–396 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zilka, O. et al. On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death. ACS Cent. Sci. 3, 232–243 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anthonymuthu, T. S. et al. Resolving the paradox of ferroptotic cell death: ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis. Redox Biol. 38, 101744 (2021).

Article  CAS  PubMed  Google Scholar 

Tyurina, Y. Y. et al. Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo. Redox Biol. 61, 102650 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kathman, S. G., Boshart, J., Jing, H. & Cravatt, B. F. Blockade of the lysophosphatidylserine lipase ABHD12 potentiates ferroptosis in cancer cells. ACS Chem. Biol. 15, 871–877 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kraft, V. A. N. et al. GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent. Sci. 6, 41–53 (2020).

Article  CAS  PubMed  Google Scholar 

Phadnis, V. V. et al. MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis. Cell Rep. 42, 113023 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zou, Y. et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature 585, 603–608 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reed, A., Ware, T., Li, H., Fernando Bazan, J. & Cravatt, B. F. TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids. Nat. Chem. Biol. 19, 378–388 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Magtanong, L. et al. Context-dependent regulation of ferroptosis sensitivity. Cell Chem. Biol. 29, 1409–1418.e6 (2022).

Article  CAS  PubMed  Google Scholar 

Magtanong, L. et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem. Biol. 26, 420–432.e9 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

von Krusenstiern, A. N. et al. Identification of essential sites of lipid peroxidation in ferroptosis. Nat. Chem. Biol. 19, 719–730 (2023).

Article  Google Scholar 

Kagan, V. E. et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat. Chem. Biol. 13, 81–90 (2017).

Article  CAS  PubMed  Google Scholar 

Pedrera, L. et al. Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ. 28, 1644–1657 (2021).

Article  CAS  PubMed  Google Scholar 

Riegman, M. et al. Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture. Nat. Cell Biol. 22, 1042–1048 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Agmon, E., Solon, J., Bassereau, P. & Stockwell, B. R. Modeling the effects of lipid peroxidation during ferroptosis on membrane properties. Sci. Rep. 8, 5155 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Roveri, A., Maiorino, M., Nisii, C. & Ursini, F. Purification and characterization of phospholipid hydroperoxide glutathione peroxidase from rat testis mitochondrial membranes. Biochim. Biophys. Acta 1208, 211–221 (1994).

Article  PubMed  Google Scholar 

Seiler, A. et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 8, 237–248 (2008).

Article  CAS  PubMed  Google Scholar 

Friedmann Angeli, J. P. et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell Biol. 16, 1180–1191 (2014).

Article  CAS  PubMed