Das M, Holzer HE. Recurrent implantation failure: gamete and embryo factors. Fertil Steril. 2012;97(5):1021–7.

Article  PubMed  Google Scholar 

Macklon N. Recurrent implantation failure is a pathology with a specific transcriptomic signature. Fertil Steril. 2017;108(1):9–14.

Article  PubMed  Google Scholar 

Polanski LT, Baumgarten MN, Quenby S, Brosens J, Campbell BK, Raine-Fenning NJ. What exactly do we mean by ‘recurrent implantation failure’? A systematic review and opinion. Reprod Biomed Online. 2014;28(4):409–23.

Article  PubMed  Google Scholar 

Rinehart J. Recurrent implantation failure: definition. J Assist Reprod Genet. 2007;24:284–7.

Article  PubMed  PubMed Central  Google Scholar 

Simon A, Laufer N. Repeated implantation failure: clinical approach. Fertil Steril. 2012;97(5):1039–43.

Article  PubMed  Google Scholar 

Craciunas L, Gallos I, Chu J, Bourne T, Quenby S, Brosens JJ, et al. Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis. Hum Reprod Update. 2019;25(2):202–23.

Article  CAS  PubMed  Google Scholar 

Cornelisse S, Zagers M, Kostova E, Fleischer K, van Wely M, Mastenbroek S. Preimplantation genetic testing for aneuploidies (abnormal number of chromosomes) in in vitro fertilisation. Cochrane Database Syst Reviews. 2020(9).

Habbema JDF, Eijkemans MJ, Leridon H, te Velde ER. Realizing a desired family size: when should couples start? Hum Reprod. 2015;30(9):2215–21.

Article  PubMed  PubMed Central  Google Scholar 

Somigliana E, Vigano P, Busnelli A, Paffoni A, Vegetti W, Vercellini P. Repeated implantation failure at the crossroad between statistics, clinics and over-diagnosis. Reprod Biomed Online. 2018;36(1):32–8.

Article  PubMed  Google Scholar 

Cimadomo D, Craciunas L, Vermeulen N, Vomstein K, Toth B. Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists. Hum Reprod. 2021;36(2):305–17.

Article  CAS  PubMed  Google Scholar 

Busnelli A, Somigliana E, Cirillo F, Baggiani A, Levi-Setti PE. Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis. Sci Rep. 2021;11(1):1747.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fox C, Morin S, Jeong J-W, Scott RT Jr, Lessey BA. Local and systemic factors and implantation: what is the evidence? Fertil Steril. 2016;105(4):873–84.

Article  PubMed  PubMed Central  Google Scholar 

Pirtea P, De Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, et al. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertil Steril. 2021;115(1):45–53.

Article  PubMed  Google Scholar 

Munné S, Kaplan B, Frattarelli JL, Child T, Nakhuda G, Shamma FN, et al. Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial. Fertil Steril. 2019;112(6):1071–9. e7.

Article  PubMed  Google Scholar 

Scott RT Jr, Ferry K, Su J, Tao X, Scott K, Treff NR. Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study. Fertil Steril. 2012;97(4):870–5.

Article  PubMed  Google Scholar 

Sato T, Sugiura-Ogasawara M, Ozawa F, Yamamoto T, Kato T, Kurahashi H, et al. Preimplantation genetic testing for aneuploidy: a comparison of live birth rates in patients with recurrent pregnancy loss due to embryonic aneuploidy or recurrent implantation failure. Hum Reprod. 2019;34(12):2340–8.

Article  PubMed  Google Scholar 

Fodina V, Dudorova A, Erenpreiss J. Evaluation of embryo aneuploidy (PGT-A) and endometrial receptivity (ERA) testing in patients with recurrent implantation failure in ICSI cycles. Gynecol Endocrinol. 2021;37(sup1):17–20.

Article  CAS  PubMed  Google Scholar 

Tong J, Niu Y, Wan A, Zhang T. Next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) of trophectoderm biopsy for recurrent implantation failure (RIF) patients: a retrospective study. Reproductive Sci. 2021;28:1923–9.

Article  CAS  Google Scholar 

Coticchio G, Behr B, Campbell A, Meseguer M, Morbeck DE, Pisaturo V, et al. Fertility technologies and how to optimize laboratory performance to support the shortening of time to birth of a healthy singleton: a Delphi consensus. J Assist Reprod Genet. 2021;38:1021–43.

Article  PubMed  PubMed Central  Google Scholar 

McLernon D, Te Velde E, Steyerberg E, Mol B, Bhattacharya S. Clinical prediction models to inform individualized decision-making in subfertile couples: a stratified medicine approach. Hum Reprod. 2014;29(9):1851–8.

Article  CAS  PubMed  Google Scholar 

McLernon DJ, Steyerberg EW, Te Velde ER, Lee AJ, Bhattacharya S. Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: population based study of linked cycle data from 113 873 women. BMJ. 2016;355.

Luke B, Brown MB, Wantman E, Lederman A, Gibbons W, Schattman GL, et al. Cumulative birth rates with linked assisted reproductive technology cycles. N Engl J Med. 2012;366(26):2483–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cimadomo D, Capalbo A, Dovere L, Tacconi L, Soscia D, Giancani A, et al. Leave the past behind: women’s reproductive history shows no association with blastocysts’ euploidy and limited association with live birth rates after euploid embryo transfers. Hum Reprod. 2021;36(4):929–40.

Article  CAS  PubMed  Google Scholar 

Koler M, Achache H, Tsafrir A, Smith Y, Revel A, Reich R. Disrupted gene pattern in patients with repeated in vitro fertilization (IVF) failure. Hum Reprod. 2009;24(10):2541–8.

Article  CAS  PubMed  Google Scholar 

Ruiz-Alonso M, Galindo N, Pellicer A, Simón C. What a difference two days make:personalized embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod. 2014;29(6):1244–7.

Article  CAS  PubMed  Google Scholar 

Choi Y, Kim H-R, Lim EJ, Park M, Yoon JA, Kim YS, et al. Integrative analyses of uterine transcriptome and microRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients with recurrent/repeated implantation failure (RIF). PLoS ONE. 2016;11(6):e0157696.

Article  PubMed  PubMed Central  Google Scholar 

Koot YE, Van Hooff SR, Boomsma CM, Van Leenen D, Groot Koerkamp MJ, Goddijn M, et al. An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF. Sci Rep. 2016;6(1):19411.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diez-Juan A, Rubio C, Marin C, Martinez S, Al-Asmar N, Riboldi M, et al. Mitochondrial DNA content as a viability score in human euploid embryos: less is better. Fertil Steril. 2015;104(3):534–41. e1.

Article  CAS  PubMed  Google Scholar 

Boynukalin FK, Gultomruk M, Cavkaytar S, Turgut E, Findikli N, Serdarogullari M, et al. Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer. PLoS ONE. 2020;15(1):e0227619.

Article  CAS  PubMed  PubMed Central  Google Scholar