Benzodiazepines for the Treatment of Seizure Clusters

Zack MM, Kobau R. National and state estimates of the numbers of adults and children with active epilepsy - United States, 2015. MMWR Morb Mortal Wkly Rep. 2017;66:821–5.

Article  PubMed  PubMed Central  Google Scholar 

Kobau R, Zahran H, Thurman DJ, et al. Epilepsy surveillance among adults–19 States, Behavioral Risk Factor Surveillance System, 2005. MMWR Surveill Summ. 2008;57:1–20.

PubMed  Google Scholar 

Haut SR, Nabbout R. Recognizing seizure clusters in the community: The path to uniformity and individualization in nomenclature and definition. Epilepsia. 2022;63(Suppl 1):S6–13.

PubMed  Google Scholar 

Jafarpour S, Hirsch LJ, Gainza-Lein M, et al. Seizure cluster: definition, prevalence, consequences, and management. Seizure. 2019;68:9–15.

Article  PubMed  Google Scholar 

Kienitz R, Kay L, Beuchat I, et al. Benzodiazepines in the management of seizures and status epilepticus: a review of routes of delivery, pharmacokinetics, efficacy, and tolerability. CNS Drugs. 2022;36:951–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Penovich PE, Buelow J, Steinberg K, et al. Burden of seizure clusters on patients with epilepsy and caregivers: survey of patient, caregiver, and clinician perspectives. Neurologist. 2017;22:207–14.

Article  PubMed  Google Scholar 

Hatoum HT, Arcona S, Mao J, et al. Real-world antiseizure medication treatment outcomes in drug-resistant focal epilepsy patients. Epilepsia Open. 2023;8:1556–65.

Kadel J, Bauer S, Hermsen AM, et al. Use of Emergency Medication in Adult Patients with Epilepsy: A Multicentre Cohort Study from Germany. CNS Drugs. 2018;32:771–81.

Article  PubMed  Google Scholar 

Cloyd J, Haut S, Carrazana E, et al. Overcoming the challenges of developing an intranasal diazepam rescue therapy for the treatment of seizure clusters. Epilepsia. 2021;62:846–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Penovich P, Wheless JW, Hogan RE, et al. Examining the patient and caregiver experience with diazepam nasal spray for seizure clusters: results from an exit survey of a phase 3, open-label, repeat-dose safety study. Epilepsy Behav. 2021;121: 108013.

Article  PubMed  Google Scholar 

Meng TC, Szaflarski JP, Chen L, et al. Psychosocial outcomes of repeated treatment of seizure clusters with midazolam nasal spray: results of a phase 3, open-label extension trial. Epilepsy Behav. 2023;138: 108989.

Article  PubMed  Google Scholar 

Buchhalter J, Shafer PO, Buelow JM, et al. Preferred practices for rescue treatment of seizure clusters: a consensus-driven, multi-stakeholder approach. Epilepsy Behav. 2021;117: 107836.

Article  PubMed  Google Scholar 

Fisher RS, Bartfeld E, Cramer JA. Use of an online epilepsy diary to characterize repetitive seizures. Epilepsy Behav. 2015;47:66–71.

Article  PubMed  Google Scholar 

Cereghino JJ, Mitchell WG, Murphy J, et al. Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group. Neurology. 1998;51:1274–82.

Article  CAS  PubMed  Google Scholar 

US Food and Drug Administration. Search orphan drug designatations and approvals. 2021. https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=61591. Accessed 3 Sep 2021.

Bausch Health US, LLC. Diastat® C-IV (diazepam rectal gel). Full Prescribing Information. Bridgewater: Bausch Health US, LLC; 2023.

Google Scholar 

Neurelis, Inc. VALTOCO® (diazepam nasal spray). Full Prescribing Information. San Diego: Neurelis Inc; 2023.

Google Scholar 

UCB, Inc. Nayzilam® (midazolam nasal spray). Full Prescribing Information. Smyrna: UCB Inc; 2023.

Google Scholar 

Haut SR, Shinnar S, Moshe SL. Seizure clustering: risks and outcomes. Epilepsia. 2005;46:146–9.

Article  PubMed  Google Scholar 

Detyniecki K, O’Bryan J, Choezom T, et al. Prevalence and predictors of seizure clusters: a prospective observational study of adult patients with epilepsy. Epilepsy Behav. 2018;88:349–56.

Article  PubMed  Google Scholar 

Mitchell WG, Conry JA, Crumrine PK, et al. An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group. Epilepsia. 1999;40:1610–7.

Article  CAS  PubMed  Google Scholar 

Ochoa-Urrea M, Lacuey N, Vilella L, et al. Seizure clusters, seizure severity markers, and SUDEP risk. Front Neurol. 2021;12: 643916.

Article  PubMed  PubMed Central  Google Scholar 

Haut SR. Seizure clusters: characteristics and treatment. Curr Opin Neurol. 2015;28:143–50.

Article  CAS  PubMed  Google Scholar 

Dingledine R, Varvel NH, Dudek FE. When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Adv Exp Med Biol. 2014;813:109–22.

Article  PubMed  PubMed Central  Google Scholar 

Haut SR, Lipton RB, LeValley AJ, et al. Identifying seizure clusters in patients with epilepsy. Neurology. 2005;65:1313–5.

Article  CAS  PubMed  Google Scholar 

Chung S, Szaflarski JP, Choi EJ, et al. A systematic review of seizure clusters: prevalence, risk factors, burden of disease and treatment patterns. Epilepsy Res. 2021;177: 106748.

Article  PubMed  Google Scholar 

Herzog AG, Carrazana E, Rabinowicz AL. A comparison of statistical versus clinical classifiers of seizure clustering in women with catamenial and noncatamenial epilepsy. Epilepsia. 2023;64:1507–15.

Article  PubMed  Google Scholar 

Dewar SR, Ranit L, Pieters HC. Reciprocal burden: adults with drug-resistant epilepsy reflect upon informal caregiver support. Seizure. 2021;89:85–92.

Article  PubMed  Google Scholar 

Wirrell EC, Nabbout R, Scheffer IE, et al. Methodology for classification and definition of epilepsy syndromes with list of syndromes: report of the ILAE Task Force on Nosology and Definitions. Epilepsia. 2022;63:1333–48.

Article  PubMed  Google Scholar 

Faught E. Economic aspects of treating seizure clusters. Epilepsia. 2022;63:S45-54.

Article  PubMed  Google Scholar 

Birnbaum AK, Leppik IE, Svensden K, et al. Prevalence of epilepsy/seizures as a comorbidity of neurologic disorders in nursing homes. Neurology. 2017;88:750–7.

Article  PubMed  PubMed Central  Google Scholar 

Klenerman P, Sander JW, Shorvon SD. Mortality in patients with epilepsy: a study of patients in long term residential care. J Neurol Neurosurg Psychiatry. 1993;56:149–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hartman AL, Devore CD, Section on Neurology, American Academy of Pediatrics, et al. Rescue medicine for epilepsy in education settings. Pediatrics. 2016;137. https://doi.org/10.1542/peds.2015-3876.

Chhabra R, Gupta R, Gupta LK. Intranasal midazolam versus intravenous/rectal benzodiazepines for acute seizure control in children: a systematic review and meta-analysis. Epilepsy Behav. 2021;125: 108390.

Article  PubMed  Google Scholar 

Dreifuss FE, Rosman NP, Cloyd JC, et al. A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med. 1998;338:1869–75.

Article  CAS  PubMed  Google Scholar 

Samanta D. Rescue therapies for seizure emergencies: current and future landscape. Neurol Sci. 2021;42:4017–27.

Article  PubMed  PubMed Central  Google Scholar 

Hogan RE, Gidal BE, Koplowitz B, et al. Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers. Epilepsia. 2020;61:455–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Haan GJ, van der Geest P, Doelman G, et al. A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations. Epilepsia. 2010;51:478–82.

Article  PubMed  Google Scholar 

Agarwal SK, Cloyd JC. Development of benzodiazepines for out-of-hospital management of seizure emergencies. Neurol Clin Pract. 2015;5:80–5.

Article  PubMed  PubMed Central  Google Scholar 

Lepkowski AM. School nursing evidence-based practice clinical guideline: students with seizures and epilepsy. Silver Spring: National Association of School Nurses; 2018.

Google Scholar 

US Food and Drug Administration. Clinical Superiority Findings. 2019. https://www.fda.gov/industry/designating-orphan-product-drugs-and-biological-products/clinical-superiority-findings. Accessed 23 June 2020.

Chung S, Peters JM, Detyniecki K, et al. The nose has it: opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters. Epilepsy Behav Rep. 2023;21: 100581.

Article  PubMed  Google Scholar 

Wheless JW, Meng TC, Van Ess PJ, et al. Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters: an open-label extension trial. Epilepsia. 2019;60:1809–19.

Article  CAS  PubMed  Google Scholar 

Detyniecki K, Van Ess PJ, Sequeira DJ, et al. Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters-a randomized, double-blind, placebo-controlled trial. Epilepsia. 2019;60:1797–808.

Article  CAS  PubMed  PubMed Central 

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