Kacena MA, Plotkin LI, Fehrenbacher JC. The use of artificial intelligence in writing scientific review articles. Curr Osteoporos Rep. https://doi.org/10.1007/s11914-023-00852-0.

Margetts TJ, Karnik SJ, Wang HS, et al. Use of AI language engine ChatGPT 4.0 to write a scientific review article examining the intersection of alzheimer’s disease and bone. Curr Osteoporos Rep. 2024. https://doi.org/10.1007/s11914-023-00853-z.

Mathers CD, et al. Causes of international increases in older age life expectancy. Lancet. 2015;385(9967):540–8.

Article  PubMed  Google Scholar 

Xia X, et al. Aging and Alzheimer’s disease: comparison and associations from molecular to system level. Aging Cell. 2018;17(5): e12802.

Article  PubMed  PubMed Central  Google Scholar 

Liang W, Chikritzhs T. The effect of age on fracture risk: a population-based cohort study. J Aging Res. 2016;2016:5071438.

Article  PubMed  PubMed Central  Google Scholar 

Cheng XG, et al. Age-related bone mineral density, bone loss rate, prevalence of osteoporosis, and reference database of women at multiple centers in China. J Clin Densitom. 2007;10(3):276–84.

Article  PubMed  Google Scholar 

Friedman SM, et al. Dementia and hip fractures: development of a pathogenic framework for understanding and studying risk. Geriatr Orthop Surg Rehabil. 2010;1(2):52–62.

Article  PubMed  PubMed Central  Google Scholar 

Tsai CH, et al. Fracture as an independent risk factor of dementia: a nationwide population-based cohort study. Medicine (Baltimore). 2014;93(26):e188.

Article  PubMed  Google Scholar 

Lui LY, et al. Bone loss predicts subsequent cognitive decline in older women: the study of osteoporotic fractures. J Am Geriatr Soc. 2003;51(1):38–43.

Article  PubMed  Google Scholar 

Dev K, et al. Prevalence of falls and fractures in Alzheimer’s patients compared to general population. Cureus. 2021;13(1):e12923.

PubMed  PubMed Central  Google Scholar 

Baker NL, et al. Hip fracture risk and subsequent mortality among Alzheimer’s disease patients in the United Kingdom, 1988–2007. Age Ageing. 2011;40(1):49–54.

Article  PubMed  Google Scholar 

Sozen T, Ozisik L, Basaran NC. An overview and management of osteoporosis. Eur J Rheumatol. 2017;4(1):46–56.

Article  PubMed  Google Scholar 

• Zhang, M, Hu S and Sun X. Alzheimer’s disease and impaired bone microarchitecture, regeneration and potential genetic links. Life (Basel). 2023;13(2). This review identifies shared pathogenic mechanisms between Alzheimer’s disease (AD) and osteoporosis and suggests that treatments targeting brain disorders could also benefit osteoporotic conditions, emphasizing the importance of preventing bone loss in AD patients.

Xia WF, et al. Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine. J Bone Miner Res. 2013;28(10):2122–35.

Article  MathSciNet  CAS  PubMed  Google Scholar 

Cui S, et al. APPswe/Abeta regulation of osteoclast activation and RAGE expression in an age-dependent manner. J Bone Miner Res. 2011;26(5):1084–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dengler-Crish CM, et al. Evidence of Wnt/beta-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer’s disease. Neurobiol Aging. 2018;67:148–58.

Article  CAS  PubMed  Google Scholar 

Dengler-Crish CM, Smith MA, Wilson GN. Early evidence of low bone density and decreased serotonergic synthesis in the Dorsal Raphe of a tauopathy model of Alzheimer’s disease. J Alzheimers Dis. 2017;55(4):1605–19.

Article  CAS  PubMed  Google Scholar 

•• JE, LL, et al. Degradation of bone quality in a transgenic mouse model of Alzheimer’s disease. J Bone Miner Res. 2022;37(12):2548-2565. This study showed that 5XFAD transgenic mice, a model for Alzheimer’s disease, exhibited altered bone quality characterized by decreased mineralization, reduced crystallinity, accumulation of advanced glycation end products (AGEs), and compromised fracture toughness, suggesting a connection between amyloid-beta accumulation in the brain and changes in bone properties.

Alzheimer’s disease facts and figures. Alzheimers Dement. 2023;19(4):1598–695.

Article  Google Scholar 

Tabaton M, Piccini A. Role of water-soluble amyloid-beta in the pathogenesis of Alzheimer’s disease. Int J Exp Pathol. 2005;86(3):139–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williamson J, Goldman J, Marder KS. Genetic aspects of Alzheimer disease. Neurologist. 2009;15(2):80–6.

Article  PubMed  PubMed Central  Google Scholar 

Armstrong RA. The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer’s disease. Folia Neuropathol. 2009;47(4):289–99.

CAS  PubMed  Google Scholar 

Riedel BC, Thompson PM, Brinton RD. Age, APOE and sex: triad of risk of Alzheimer’s disease. J Steroid Biochem Mol Biol. 2016;160:134–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Breijyeh Z and Karaman R. Comprehensive review on Alzheimer’s disease: Causes and Treatment. Molecules. 2020;25(24).

Du X, Wang X, Geng M. Alzheimer’s disease hypothesis and related therapies. Transl Neurodegener. 2018;7:2.

Article  PubMed  PubMed Central  Google Scholar 

Cras P, et al. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci U S A. 1991;88(17):7552–6.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Perl DP. Neuropathology of Alzheimer’s disease. Mt Sinai J Med. 2010;77(1):32–42.

Article  PubMed  PubMed Central  Google Scholar 

Paris D, et al. Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis. Neurosci Lett. 2004;366(1):80–5.

Article  CAS  PubMed  Google Scholar 

Chen GF, et al. Amyloid beta: structure, biology and structure-based therapeutic development. Acta Pharmacol Sin. 2017;38(9):1205–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Metcalfe MJ, Figueiredo-Pereira ME. Relationship between tau pathology and neuroinflammation in Alzheimer’s disease. Mt Sinai J Med. 2010;77(1):50–8.

Article  PubMed  PubMed Central  Google Scholar 

Heneka MT, et al. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015;14(4):388–405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banks WA, et al. Healthy aging and the blood-brain barrier. Nat Aging. 2021;1(3):243–54.

Article  PubMed  PubMed Central  Google Scholar 

Jefferies WA, et al. Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease. Alzheimers Res Ther. 2013;5(6):64.

Article  PubMed  PubMed Central  Google Scholar 

Li W, Lo EH. Leaky memories: Impact of APOE4 on blood-brain barrier and dementia. J Cereb Blood Flow Metab. 2020;40(9):1912–4.

Article  PubMed  PubMed Central  Google Scholar 

Montagne A, et al. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020;581(7806):71–6.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Lee HS, et al. Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface. FEBS J. 2009;276(17):4622–35.

Article  CAS  PubMed  Google Scholar 

Paris D, et al. Inhibition of angiogenesis by Abeta peptides. Angiogenesis. 2004;7(1):75–85.

Article  CAS  PubMed  Google Scholar 

Govindpani K, et al. Vascular dysfunction in Alzheimer’s disease: a prelude to the pathological process or a consequence of it? J Clin Med. 2019;8(5).

Sarafrazi N, Wambogo EA, Shepherd JA. Osteoporosis or low bone mass in older adults: United States, 2017–2018. NCHS Data Brief. 2021;405:1–8.

Google Scholar 

Singer A, et al. Treatment rates and healthcare costs of patients with fragility fracture by site of care: a real-world data analysis. Arch Osteoporos. 2023;18(1):42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brandi ML. Microarchitecture, the key to bone quality. Rheumatology (Oxford). 2009;48(4):IV3-8.

PubMed  Google Scholar 

Melton LJ 3rd, et al. Fracture risk in patients with Alzheimer’s disease. J Am Geriatr Soc. 1994;42(6):614–9.

Article  PubMed  Google Scholar 

Tolppanen AM, et al. Incident hip fractures among community dwelling persons with Alzheimer’s disease in a Finnish nationwide register-based cohort. PLoS One. 2013;8(3):e59124.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Amboni M, Barone P, Hausdorff JM. Cognitive contributions to gait and falls: evidence and implications. Mov Disord. 2013;28(11):1520–33.