Bouchez C, Devin A (2019) Mitochondrial Biogenesis and mitochondrial reactive oxygen species (ROS): a complex relationship regulated by the cAMP/PKA signaling pathway. Cells 8:287

Cao Q, Chen J, Zhang Z, Shu S, Qian Y, Yang L, Xu L, Zhang Y, Bao X, Xia S, Yang H, Xu Y, Qiu S (2023) Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia. J Neuroinflammation 20:105

Article  PubMed  PubMed Central  Google Scholar 

Cao S, Wang C, Yan J, Li X, Wen J, Hu C (2020) Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway. Free Radic Biol Med 147:8–22

Article  PubMed  Google Scholar 

Chen QM (2022) Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury. Free Radic Biol Med 179:133–143

Article  PubMed  Google Scholar 

Chen N, Ge MM, Li DY, Wang XM, Liu DQ, Ye DW, Tian YK, Zhou YQ, Chen JP (2021a) beta2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis. Biomed Pharmacother 144:112331

Article  PubMed  Google Scholar 

Chen Q, Kong L, Xu Z, Cao N, Tang X, Gao R, Zhang J, Deng S, Tan C, Zhang M, Wang Y, Zhang L, Ma K, Li L, Si J (2021b) The role of TMEM16A/ERK/NK-1 signaling in dorsal root ganglia neurons in the development of neuropathic pain induced by spared nerve injury (SNI). Mol Neurobiol 58:5772–5789

Article  PubMed  PubMed Central  Google Scholar 

Chen XJ, Wang L, Song XY (2020) Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction. Biomed Pharmacother 125:110003

Article  PubMed  Google Scholar 

De Gregorio D, McLaughlin RJ, Posa L, Ochoa-Sanchez R, Enns J, Lopez-Canul M, Aboud M, Maione S, Comai S, Gobbi G (2019) Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain 160:136–150

Article  PubMed  Google Scholar 

Depre C, Wang L, Sui X, Qiu H, Hong C, Hedhli N, Ginion A, Shah A, Pelat M, Bertrand L, Wagner T, Gaussin V, Vatner SF (2006) H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart. Circ Res 98:280–288

Article  PubMed  Google Scholar 

Drake JC et al (2021) Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proc Natl Acad Sci U S A 118:e2025932118

Fan H, Ding R, Liu W, Zhang X, Li R, Wei B, Su S, Jin F, Wei C, He X, Li X, Duan C (2021) Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1alpha signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats. Redox Biol 40:101856

Article  PubMed  PubMed Central  Google Scholar 

Flatters SJL, Bennett GJ (2006) Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: evidence for mitochondrial dysfunction. Pain 122:245–257

Article  PubMed  PubMed Central  Google Scholar 

Gao X, Kim HK, Mo Chung J, Chung K (2007) Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. Pain 131:262–271

Article  PubMed  PubMed Central  Google Scholar 

Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ (2019) Genetic liver-specific AMPK activation protects against Diet-Induced obesity and NAFLD. Cell Rep 26:192-208e196

Article  PubMed  PubMed Central  Google Scholar 

Guo A, Li K, Tian HC, Fan Z, Chen QN, Yang YF, Yu J, Wu YX, Xiao Q (2021) FGF19 protects skeletal muscle against obesity-induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT-1/PGC-alpha pathway. J Cell Mol Med 25:3585–3600

Article  PubMed  PubMed Central  Google Scholar 

Han YC, Tang SQ, Liu YT, Li AM, Zhan M, Yang M, Song N, Zhang W, Wu XQ, Peng CH, Zhang H, Yang S (2021) AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice. Cell Death Dis 12:925

Article  PubMed  PubMed Central  Google Scholar 

Hao L, Zhong W, Dong H, Guo W, Sun X, Zhang W, Yue R, Li T, Griffiths A, Ahmadi AR, Sun Z, Song Z, Zhou Z (2021) ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1-TFAM signalling in alcoholic steatohepatitis. Gut 70:1933–1945

Article  PubMed  Google Scholar 

Herzig S, Shaw RJ (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19:121–135

Article  PubMed  Google Scholar 

Jiang J, Xu L, Yang L, Liu S, Wang Z (2023) Mitochondrial-derived peptide MOTS-c ameliorates spared nerve Injury-Induced Neuropathic Pain in mice by inhibiting Microglia activation and neuronal oxidative damage in the spinal cord via the AMPK pathway. ACS Chem Neurosci 14:2362–2374

Article  PubMed  Google Scholar 

Jo HS, Kim DW, Shin MJ, Cho SB, Park JH, Lee CH, Yeo EJ, Choi YJ, Yeo HJ, Sohn EJ, Son O, Cho SW, Kim DS, Yu YH, Lee KW, Park J, Eum WS, Choi SY (2017) Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway. Mol Brain 10:1

Article  PubMed  PubMed Central  Google Scholar 

Kang D, Kim SH, Hamasaki N (2007) Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion 7:39–44

Article  PubMed  Google Scholar 

Khasabova IA, Khasabov SG, Olson JK, Uhelski ML, Kim AH, Albino-Ramirez AM, Wagner CL, Seybold VS, Simone DA (2019) Pioglitazone, a PPARgamma agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress. Pain 160:688–701

Article  PubMed  Google Scholar 

Kumar Kalvala A, Bagde A, Arthur P, Kumar Surapaneni S, Ramesh N, Nathani A, Singh M (2022) Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents. Int Immunopharmacol 107:108693

Article  PubMed  Google Scholar 

Lee DZ, Chung JM, Chung K, Kang MG (2012) Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Pain 153:1905–1915

Article  PubMed  PubMed Central  Google Scholar 

Li Y, Feng YF, Liu XT, Li YC, Zhu HM, Sun MR, Li P, Liu B, Yang H (2021a) Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis. Redox Biol 38:101771

Article  PubMed  Google Scholar 

Li J, Tian M, Hua T, Wang H, Yang M, Li W, Zhang X, Yuan H (2021b) Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain. Autophagy 17:4062–4082

Article  PubMed  PubMed Central  Google Scholar 

Li F, Yang B, Li T, Gong X, Zhou F, Hu Z (2019) HSPB8 over-expression prevents disruption of blood-brain barrier by promoting autophagic flux after cerebral ischemia/reperfusion injury. J Neurochem 148:97–113

Article  PubMed  Google Scholar 

Li J, Zhang L, Xu C, Shen YY, Lin YH, Zhang Y, Wu HY, Chang L, Zhang YD, Chen R, Zhang ZP, Luo CX, Li F, Zhu DY (2021c) A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and alpha2-containning GABA(A)rs. Theranostics 11:5970–5985

Article  PubMed  PubMed Central  Google Scholar 

Lin SC, Hardie DG (2018) AMPK: sensing glucose as well as cellular energy status. Cell Metab 27:299–313

Article  PubMed  Google Scholar 

Liu ZY, Song ZW, Guo SW, He JS, Wang SY, Zhu JG, Yang HL, Liu JB (2019) CXCL12/CXCR4 signaling contributes to neuropathic pain via central sensitization mechanisms in a rat spinal nerve ligation model. CNS Neurosci Ther 25:922–936

Article  PubMed  PubMed Central  Google Scholar 

Lu X, Xuan W, Li J, Yao H, Huang C, Li J (2021) AMPK protects against alcohol-induced liver injury through UQCRC2 to up-regulate mitophagy. Autophagy 17:3622–3643

Article  PubMed  PubMed Central  Google Scholar 

Maixner DW, Yan X, Hooks SB, Weng HR (2016) AMPKalpha1 knockout enhances nociceptive behaviors and spinal glutamatergic synaptic activities via production of reactive oxygen species in the spinal dorsal horn. Neuroscience 326:158–169

Article  PubMed  Google Scholar 

Malik N, Ferreira BI, Hollstein PE, Curtis SD, Trefts E, Weiser Novak S, Yu J, Gilson R, Hellberg K, Fang L, Sheridan A, Hah N, Shadel GS, Manor U, Shaw RJ (2023) Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. Science 380:eabj5559

Article  PubMed  PubMed Central  Google Scholar 

Mattson MP, Gleichmann M, Cheng A (2008) Mitochondria in neuroplasticity and neurological disorders. Neuron 60:748–766

Article  PubMed  PubMed Central  Google Scholar 

Park SE, Neupane C, Noh C, Sharma R, Shin HJ, Pham TL, Lee GS, Park KD, Lee CJ, Kang DW, Lee SY, Kim HW, Park JB (2022) Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model. Mol Brain 15:41

Article  PubMed  PubMed Central  Google Scholar 

Qiu H, Lizano P, Laure L, Sui X, Rashed E, Park JY, Hong C, Gao S, Holle E, Morin D, Dhar SK, Wagner T, Berdeaux A, Tian B, Vatner SF, Depre C (2011) H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload. Circulation 124:406–415

Article  PubMed  PubMed Central  Google Scholar 

Ren Y, Shen HM (2019) Critical role of AMPK in redox regulation under glucose starvation. Redox Biol 25:101154

Article  PubMed  PubMed Central  Google Scholar 

Shao S, Xu CB, Chen CJ, Shi GN, Guo QL, Zhou Y, Wei YZ, Wu L, Shi