Barriers, facilitators, perceptions and impact of interventions in implementing antimicrobial stewardship programs in hospitals of low-middle and middle countries: a scoping review

Kakkar AK, Shafiq N, Singh G, Ray P, Gautam V, Agarwal R, Muralidharan J, Arora P. Antimicrobial stewardship programs in resource constrained environments: understanding and addressing the need of the systems. Front Public Health. 2020;8:140.

Article  PubMed  PubMed Central  Google Scholar 

Van Dijck C, Vlieghe E, Cox JA. Antibiotic stewardship interventions in hospitals in low-and middle-income countries: a systematic review. Bull World Health Organ. 2018;96(4):266–80.

Article  PubMed  PubMed Central  Google Scholar 

Murray CJ, Ikuta KS, Sharara F, Swetschinski L, Aguilar GR, Gray A, Han C, Bisignano C, Rao P, Wool E, Johnson SC. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629–55.

Article  CAS  Google Scholar 

Mestrovic T, Aguilar GR, Swetschinski LR, Ikuta KS, Gray AP, Weaver ND, Han C, Wool EE, Hayoon AG, Hay SI, Dolecek C. The burden of bacterial antimicrobial resistance in the WHO European region in 2019: a cross-country systematic analysis. Lancet Public Health. 2022;7(11):e897–913.

Article  Google Scholar 

Harun MGD, Anwar MMU, Sumon SA, Hassan MZ, Haque T, Mah EMS, Rahman A, Abdullah S, Islam MS, Styczynski AR, Kaydos-Daniels SC. Infection prevention and control in tertiary care hospitals of Bangladesh: results from WHO infection prevention and control assessment framework (IPCAF). Antimicrob Resist Infect Control. 2022;11(1):125.

Article  PubMed  PubMed Central  Google Scholar 

Pokharel S, Raut S, Adhikari B. Tackling antimicrobial resistance in low-income and middle-income countries. BMJ Glob Health. 2019;4(6):e002104.

Article  PubMed  PubMed Central  Google Scholar 

Mzumara GW, Mambiya M, Iroh Tam PY. Antimicrobial stewardship interventions in least developed and low-income countries: a systematic review protocol. BMJ Open. 2021;11(8):e047312.

Article  PubMed  PubMed Central  Google Scholar 

Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11(9):692–701.

Article  PubMed  PubMed Central  Google Scholar 

Zellweger RM, Carrique-Mas J, Limmathurotsakul D, Day NPJ, Thwaites GE, Baker S. A current perspective on antimicrobial resistance in Southeast Asia. J Antimicrob Chemother. 2017;72(11):2963–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akpan MR, Isemin NU, Udoh AE, Ashiru-Oredope D. Implementation of antimicrobial stewardship programmes in African countries: a systematic literature review. J Glob Antimicrob Resist. 2020;22:317–24.

Article  PubMed  Google Scholar 

Chetty S, Reddy M, Ramsamy Y, Naidoo A, Essack S. Antimicrobial stewardship in South Africa: a scoping review of the published literature. JAC Antimicrob Resist. 2019;1(3):dlz060.

Article  PubMed  PubMed Central  Google Scholar 

Laxminarayan R, Duse A, Wattal C, Zaidi AK, Wertheim HF, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Goossens H, et al. Antibiotic resistance-the need for global solutions. Lancet Infect Dis. 2013;13(12):1057–98.

Article  PubMed  Google Scholar 

Mendelson M, Matsoso MP. The World Health Organization Global Action Plan for antimicrobial resistance. S Afr Med J. 2015;105(5):325.

Article  PubMed  Google Scholar 

Harun MGD, Anwar MMU, Sumon SA, Hassan MZ, Mohona TM, Rahman A, Abdullah S, Islam MS, Kaydos-Daniels SC, Styczynski AR. Rationale and guidance for strengthening infection prevention and control measures and antimicrobial stewardship programs in Bangladesh: a study protocol. BMC Health Serv Res. 2022;22(1):1239.

Article  PubMed  PubMed Central  Google Scholar 

Nathwani D, Varghese D, Stephens J, Ansari W, Martin S, Charbonneau C. Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review. Antimicrob Resist Infect Control. 2019;8:35.

Article  PubMed  PubMed Central  Google Scholar 

Hegewisch-Taylor J, Dreser-Mansilla A, Romero-Mónico J, Levy-Hara G. Antimicrobial stewardship in hospitals in Latin America and the Caribbean: a scoping review. Rev Panam Salud Publica. 2020;44:e68.

Article  PubMed  PubMed Central  Google Scholar 

Kaki R, Elligsen M, Walker S, Simor A, Palmay L, Daneman N. Impact of antimicrobial stewardship in critical care: a systematic review. J Antimicrob Chemother. 2011;66(6):1223–30.

Article  CAS  PubMed  Google Scholar 

Septimus EJ, Owens RC Jr. Need and potential of antimicrobial stewardship in community hospitals. Clin Infect Dis. 2011;53(Suppl 1):S8-s14.

Article  PubMed  Google Scholar 

Schuts EC, Hulscher M, Mouton JW, Verduin CM, Stuart J, Overdiek H, van der Linden PD, Natsch S, Hertogh C, Wolfs TFW, et al. Current evidence on hospital antimicrobial stewardship objectives: a systematic review and meta-analysis. Lancet Infect Dis. 2016;16(7):847–56.

Article  PubMed  Google Scholar 

Davey P, Brown E, Charani E, Fenelon L, Gould IM, Holmes A, Ramsay CR, Wiffen PJ, Wilcox M. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2013;4:Cd003543.

Google Scholar 

Hulscher M, Prins JM. Antibiotic stewardship: does it work in hospital practice? A review of the evidence base. Clin Microbiol Infect. 2017;23(11):799–805.

Article  CAS  PubMed  Google Scholar 

Mendelson M, Røttingen JA, Gopinathan U, Hamer DH, Wertheim H, Basnyat B, Butler C, Tomson G, Balasegaram M. Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries. Lancet. 2016;387(10014):188–98.

Article  PubMed  Google Scholar 

Cox JA, Vlieghe E, Mendelson M, Wertheim H, Ndegwa L, Villegas MV, Gould I, Levy Hara G. Antibiotic stewardship in low- and middle-income countries: the same but different? Clin Microbiol Infect. 2017;23(11):812–8.

Article  CAS  PubMed  Google Scholar 

Setiawan E, Abdul-Aziz MH, Roberts JA, Cotta MO. Hospital-based antimicrobial stewardship programs used in low- and middle-income countries: a scoping review. Microb Drug Resist. 2022;28(5):566–84.

Article  CAS  PubMed  Google Scholar 

Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.

Article  PubMed  Google Scholar 

Bank W. World bank data. Washington, DC: World Bank; 2020.

Google Scholar 

Sayegh N, Hallit S, Hallit R, Saleh N, Zeidan RK. Physicians’ attitudes on the implementation of an antimicrobial stewardship program in Lebanese hospitals. Pharm Pract (Granada). 2021;19(1):2192.

Article  PubMed  Google Scholar 

Mathew P, Ranjalkar J, Chandy SJ. Challenges in implementing antimicrobial stewardship programmes at secondary level hospitals in India: an exploratory study. Front Public Health. 2020;8:493904.

Article  PubMed  PubMed Central  Google Scholar 

Gebretekle GB, Haile Mariam D, Abebe W, Amogne W, Tenna A, Fenta TG, Libman M, Yansouni CP, Semret M. Opportunities and barriers to implementing antibiotic stewardship in low and middle-income countries: lessons from a mixed-methods study in a tertiary care hospital in Ethiopia. PLoS ONE. 2018;13(12):e0208447.

Article  PubMed  PubMed Central  Google Scholar 

Baubie K, Shaughnessy C, Kostiuk L, Varsha Joseph M, Safdar N, Singh SK, Siraj D, Sethi A, Keating J. Evaluating antibiotic stewardship in a tertiary care hospital in Kerala, India: a qualitative interview study. BMJ Open. 2019;9(5):e026193.

Article  PubMed  PubMed Central  Google Scholar 

Hayat K, Rosenthal M, Gillani AH, Zhai P, Aziz MM, Ji W, Chang J, Hu H, Fang Y. Perspective of Pakistani physicians towards hospital antimicrobial stewardship programs: a multisite exploratory qualitative study. Int J Environ Res Public Health. 2019;16(9):1565.

Article  PubMed  PubMed Central  Google Scholar 

Nassar H, Abu-Farha R, Barakat M, Alefishat E. Antimicrobial stewardship from health professionals’ perspective: awareness, barriers, and level of implementation of the program. Antibiotics (Basel). 2022;11(1):99.

Article  PubMed  Google Scholar 

Oshun P, Roberts A, Osuagwu C, Akintan P, Fajolu I, Ola-Bello O, Odukoya O, Akodu B, Okunowo A, Versporten A. Roll out of a successful antimicrobial stewardship programme in Lagos university teaching hospital Nigeria using the Global-Point prevalence survey. Afr J Clin Exp Microbiol. 2021;22(2):260–72.

Article  Google Scholar 

Nampoothiri V, Sudhir AS, Joseph MV, Mohamed Z, Menon V, Charani E, Singh S. Mapping the implementation of a clinical pharmacist-driven antimicrobial stewardship programme at a tertiary care centre in South India. Antibiotics (Basel). 2021;10(2):220.

Article  PubMed  Google Scholar 

Scheepers LN, Niesing CM, Bester P. Facilitators and barriers to implementing antimicrobial stewardship programs in public South African hospitals. Antimicrob Steward Healthc Epidemiol. 2023;3(1):e34.

Article  PubMed  PubMed Central  Google Scholar 

Fabre V, Secaira C, Cosgrove SE, Lessa FC, Patel TS, Alvarez AA, Anchiraico LM, Del Carmen BM, Barberis MF, Burokas MS, et al. Deep dive into gaps and barriers to implementation of antimicrobial stewardship programs in hospitals in Latin America. Clin Infect Dis. 2023;77(Suppl 1):S53-s61.

Article  PubMed  PubMed Central  Google Scholar 

Chang FY, Chuang YC, Veeraraghavan B, Apisarnthanarak A, Tayzon MF, Kwa AL, Chiu CH, Deris ZZ, Amir Husin S, Hashim H, et al. Gaps in antimicrobial stewardship programmes in Asia: a survey of 10 countries. JAC Antimicrob Resist. 2022;4(6):dlac117.

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif