Proto-Oncogene Proteins c-bcr

A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

推出的年份: 2006(1988)

树号: D08.811.913.696.620.682.700.759, D12.644.360.325.300.099.500, D12.776.476.325.300.099.500, D12.776.476.563.759, D12.776.624.664.700.171

MeSH 单一 ID: D051562

进入的组:

Proto Oncogene Proteins c bcr
c-bcr, Proto-Oncogene Proteins
Proto-Oncogene Protein c-bcr
Proto Oncogene Protein c bcr
c-bcr, Proto-Oncogene Protein
Breakpoint Cluster Region Protein
c-bcr Proteins
c bcr Proteins
c-bcr Proto-Oncogene Proteins
Proto-Oncogene Proteins, c-bcr
c bcr Proto Oncogene Proteins
bcr Proto-Oncogene Proteins
Proto-Oncogene Proteins, bcr
bcr Proto Oncogene Proteins
Proto-Oncogene Protein bcr
Proto Oncogene Protein bcr

All MeSH Categories
- Chemicals and Drugs Category
  - Enzymes and Coenzymes [D08]
    - Enzymes [D08.811]
      - Transferases [D08.811.913]
        
        Phosphotransferases [D08.811.913.696]
        
        Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        3-Phosphoinositide-Dependent Protein Kinases [D08.811.913.696.620.682.700.745]
        
        Activin Receptors [D08.811.913.696.620.682.700.062] add_circle
        
        AMP-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.074]
        
        AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
        
        Ataxia Telangiectasia Mutated Proteins [D08.811.913.696.620.682.700.097]
        
        Aurora Kinases [D08.811.913.696.620.682.700.103] add_circle
        
        Autophagy-Related Protein-1 Homolog [D08.811.913.696.620.682.700.108]
        
        Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109] add_circle
        
        Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125] add_circle
        
        Casein Kinases [D08.811.913.696.620.682.700.140] add_circle
        
        Checkpoint Kinase 1 [D08.811.913.696.620.682.700.143]
        
        Checkpoint Kinase 2 [D08.811.913.696.620.682.700.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150] add_circle
        
        DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
        
        Doublecortin-Like Kinases [D08.811.913.696.620.682.700.275]
        
        eIF-2 Kinase [D08.811.913.696.620.682.700.300]
        
        G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364] add_circle
        
        Germinal Center Kinases [D08.811.913.696.620.682.700.397]
        
        Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429] add_circle
        
        I-kappa B Kinase [D08.811.913.696.620.682.700.494]
        
        Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D08.811.913.696.620.682.700.534]
        
        Lim Kinases [D08.811.913.696.620.682.700.542]
        
        MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559] add_circle
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565] add_circle
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567] add_circle
        
        Myotonin-Protein Kinase [D08.811.913.696.620.682.700.576]
        
        NIMA-Related Kinases [D08.811.913.696.620.682.700.581] add_circle
        
        Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
        
        p21-Activated Kinases [D08.811.913.696.620.682.700.596]
        
        Phytochrome A [D08.811.913.696.620.682.700.606]
        
        Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
        
        Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646] add_circle
        
        Protein Kinase C [D08.811.913.696.620.682.700.725] add_circle
        
        Protein Kinase D2 [D08.811.913.696.620.682.700.750]
        
        Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
        
        Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
        
        Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D08.811.913.696.620.682.700.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D08.811.913.696.620.682.700.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D08.811.913.696.620.682.700.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801] add_circle
        
        rho-Associated Kinases [D08.811.913.696.620.682.700.814]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862] add_circle
        
        Serine-Threonine Kinase 3 [D08.811.913.696.620.682.700.897]
        
        TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931] add_circle
        
        Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D08.811.913.696.620.682.700.982]

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Peptides [D12.644]
      - Intracellular Signaling Peptides and Proteins [D12.644.360]
        
        GTP-Binding Protein Regulators [D12.644.360.325]
        
        Guanine Nucleotide Exchange Factors [D12.644.360.325.300]
        
        Rho Guanine Nucleotide Exchange Factors [D12.644.360.325.300.099]
        
        Proto-Oncogene Proteins c-bcr [D12.644.360.325.300.099.500]
        
        Proto-Oncogene Proteins c-vav [D12.644.360.325.300.099.750]

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Proteins [D12.776]
      - Intracellular Signaling Peptides and Proteins [D12.776.476]
        
        GTP-Binding Protein Regulators [D12.776.476.325]
        
        Guanine Nucleotide Exchange Factors [D12.776.476.325.300]
        
        Rho Guanine Nucleotide Exchange Factors [D12.776.476.325.300.099]
        
        Proto-Oncogene Proteins c-bcr [D12.776.476.325.300.099.500]
        
        Proto-Oncogene Proteins c-vav [D12.776.476.325.300.099.750]

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Proteins [D12.776]
      - Intracellular Signaling Peptides and Proteins [D12.776.476]
        
        Protein Serine-Threonine Kinases [D12.776.476.563]
        
        3-Phosphoinositide-Dependent Protein Kinases [D12.776.476.563.745]
        
        Activin Receptors [D12.776.476.563.062] add_circle
        
        AMP-Activated Protein Kinase Kinases [D12.776.476.563.074]
        
        AMP-Activated Protein Kinases [D12.776.476.563.085]
        
        Ataxia Telangiectasia Mutated Proteins [D12.776.476.563.097]
        
        Aurora Kinases [D12.776.476.563.103] add_circle
        
        Autophagy-Related Protein-1 Homolog [D12.776.476.563.108]
        
        Bone Morphogenetic Protein Receptors [D12.776.476.563.109] add_circle
        
        Calcium-Calmodulin-Dependent Protein Kinases [D12.776.476.563.125] add_circle
        
        Casein Kinases [D12.776.476.563.140] add_circle
        
        Checkpoint Kinase 1 [D12.776.476.563.143]
        
        Checkpoint Kinase 2 [D12.776.476.563.145]
        
        Cyclic Nucleotide-Regulated Protein Kinases [D12.776.476.563.150] add_circle
        
        DNA-Activated Protein Kinase [D12.776.476.563.250]
        
        Doublecortin-Like Kinases [D12.776.476.563.275]
        
        eIF-2 Kinase [D12.776.476.563.300]
        
        G-Protein-Coupled Receptor Kinases [D12.776.476.563.364] add_circle
        
        Germinal Center Kinases [D12.776.476.563.397]
        
        Glycogen Synthase Kinases [D12.776.476.563.429] add_circle
        
        I-kappa B Kinase [D12.776.476.563.494]
        
        Interleukin-1 Receptor-Associated Kinases [D12.776.476.563.526]
        
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 [D12.776.476.563.534]
        
        Lim Kinases [D12.776.476.563.542]
        
        MAP Kinase Kinase Kinases [D12.776.476.563.554] add_circle
        
        Mitogen-Activated Protein Kinase Kinases [D12.776.476.563.565] add_circle
        
        Mitogen-Activated Protein Kinases [D12.776.476.563.567] add_circle
        
        Myotonin-Protein Kinase [D12.776.476.563.576]
        
        NIMA-Related Kinases [D12.776.476.563.581] add_circle
        
        Oncogene Protein v-akt [D12.776.476.563.586]
        
        p21-Activated Kinases [D12.776.476.563.596]
        
        Phytochrome A [D12.776.476.563.606]
        
        Positive Transcriptional Elongation Factor B [D12.776.476.563.626]
        
        Proline-Directed Protein Kinases [D12.776.476.563.646] add_circle
        
        Protein Kinase C [D12.776.476.563.725] add_circle
        
        Protein Kinase D2 [D12.776.476.563.750]
        
        Proto-Oncogene Proteins c-akt [D12.776.476.563.755]
        
        Proto-Oncogene Proteins c-bcr [D12.776.476.563.759]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.476.563.776]
        
        Pyruvate Dehydrogenase Acetyl-Transferring Kinase [D12.776.476.563.783]
        
        Receptor, Transforming Growth Factor-beta Type I [D12.776.476.563.789]
        
        Receptor, Transforming Growth Factor-beta Type II [D12.776.476.563.795]
        
        Receptor-Interacting Protein Serine-Threonine Kinases [D12.776.476.563.801] add_circle
        
        rho-Associated Kinases [D12.776.476.563.814]
        
        Ribosomal Protein S6 Kinases [D12.776.476.563.862] add_circle
        
        Serine-Threonine Kinase 3 [D12.776.476.563.897]
        
        TOR Serine-Threonine Kinases [D12.776.476.563.931] add_circle
        
        Vacuolar Sorting Protein VPS15 [D12.776.476.563.965]
        
        WNK Lysine-Deficient Protein Kinase 1 [D12.776.476.563.982]

All MeSH Categories
- Chemicals and Drugs Category
  - Amino Acids, Peptides, and Proteins [D12]
    - Proteins [D12.776]
      - Neoplasm Proteins [D12.776.624]
        
        Oncogene Proteins [D12.776.624.664]
        
        Proto-Oncogene Proteins [D12.776.624.664.700]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169] add_circle
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Fusion Proteins, bcr-abl [D12.776.624.664.700.171.500]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175] add_circle
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204] add_circle
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830] add_circle
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

MeSH 搜索器

Proto-Oncogene Proteins c-bcr

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