the PROTECT investigators:

Principal Investigators Koichi Node9, Toyoaki Murohara10

Research Advisor Masafumi Kitakaze11

Steering Committee Yoshihiko Nishio12, Teruo Inoue13, Mitsuru Ohishi12, Kazuomi Kario14, Masataka Sata15, Michio Shimabukuro16, Wataru Shimizu17, Hideaki Jinnouchi18, Isao Taguchi19, Hirofumi Tomiyama20, Koji Maemura21

Executive Committee Makoto Suzuki22, Shinichi Ando23, Kazuo Eguchi24, Haruo Kamiya25, Tomohiro Sakamoto26, Hiroki Teragawa27, Mamoru Nanasato28

Data and Safety Monitoring Board Munehide Matsuhisa15, Junya Ako29, Yoshimasa Aso13, Masaharu Ishihara30, Kazuo Kitagawa31, Akira Yamashina32

Tsukuba Echo Core Laboratory. LLC Tomoko Ishizu33

Monitoring Yumi Ikehara34, Shinichiro Ueda34

Audit Team35

Data Center and Data Management Ayako Takamori36

Statistical Analysis Hisako Yoshida37, Takumi Imai38

Study Secretariat Atsushi Tanaka9

Site Investigators (duplicates excluded) Machiko Asaka9, Tetsuya Kaneko9, Masashi Sakuma13, Shigeru Toyoda13, Takahisa Nasuno13, Michiya Kageyama13, Jojima Teruo13, Iijima Toshie13, Haruka Kishi13, Hirotsugu Yamada15, Kenya Kusunose15, Daiju Fukuda15, Shusuke Yagi15, Koji Yamaguchi15, Takayuki Ise15, Yutaka Kawabata15, Akio Kuroda15, Yuichi Akasaki12, Mihoko Kurano12, Satoshi Hoshide14, Takahiro Komori14, Tomoyuki Kabutoya14, Yukiyo Ogata14, Yuji Koide21, Hiroaki Kawano21, Satoshi Ikeda21, Satoki Fukae21, Seiji Koga21, Yukihito Higashi39, Shinji Kishimoto39, Masato Kajikawa39, Tatsuya Maruhashi39, Yoshiaki Kubota17, Yoshisato Shibata40, Nehiro Kuriyama40, Ikuko Nakamura41, Kanemitsu Hironori42, Bonpei Takase43, Yuichi Orita27, Chikage Oshita27, Yuko Uchimura27, Ruka Yoshida44, Yukihiko Yoshida44, Hirohiko Suzuki44, Yasuhiro Ogura44, Mayuho Maeda44, Masaki Takenaka44, Takumi Hayashi44, Mirai Hirose44, Itaru Hisauchi19, Toshiaki Kadokami23, Ryo Nakamura23, Junji Kanda45, Kazuo Matsunaga46, Masaaki Hoshiga47, Koichi Sohmiya47, Yumiko Kanzaki47, Arihiro Koyosue48, Hiroki Uehara49, Naoto Miyagi49, Toshiya Chinen49, Kentaro Nakamura49, Chikashi Nago49, Suguru Chiba49, Sho Hatano49, Yoshikatsu Gima49, Masami Abe49, Masayoshi Ajioka50, Hiroshi Asano50, Yoshihiro Nakashima50, Hiroyuki Osanai50, Takahiro Kanbara50, Yusuke Sakamoto50, Mitsutoshi Oguri51, Shiou Ohguchi51, Kunihiko Takahara51, Kazuhiro Izumi51, Kenichiro Yasuda51, Akihiro Kudo16, Noritaka Machii16, Ryota Morimoto10, Yasuko Bando10, Takahiro Okumura10, Toru Kondo10, Shin-ichiro Miura52, Yuhei Shiga52, Joji Mirii52, Makoto Sugihara52, Tadaaki Arimura52, Junko Nakano53, Tomohiro Sakamoto26, Kazuhisa Kodama26, Nobuyuki Ohte54, Tomonori Sugiura54, Kazuaki Wakami54, Yasuhiko Takemoto55, Minoru Yoshiyama55, Taichi Shuto55, Kazuo Fukumoto55, Yosuke Okada56, Kenichi Tanaka56, Satomi Sonoda56, Akemi Tokutsu56, Takashi Otsuka56, Fumi Uemura56, Kenji Koikawa56, Megumi Miyazaki56, Maiko Umikawa56, Manabu Narisawa56, Machi Furuta57, Hiroshi Minami58, Masaru Doi59, Kazuhiro Sugimoto60, Susumu Suzuki60, Akira Kurozumi61, Kosuke Nishio61