Marder SR, Cannon TD. Schizophrenia. N Engl J Med. 2019;381(18):1753–61.

Article  CAS  PubMed  Google Scholar 

Doorduin J, de Vries EF, Willemsen AT, de Groot JC, Dierckx RA, Klein HC. Neuroinflammation in schizophrenia-related psychosis: a PET study. J Nucl Med. 2009;50(11):1801–7.

Article  PubMed  Google Scholar 

van Berckel BN, Bossong MG, Boellaard R, Kloet R, Schuitemaker A, Caspers E, et al. Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study. Biol Psychiatry. 2008;64(9):820–2.

Article  PubMed  Google Scholar 

Barichello T, Simoes LR, Quevedo J, Zhang XY. Microglial activation and psychotic disorders: evidence from pre-clinical and clinical studies. Curr Top Behav Neurosci. 2020;44:161–205.

Article  CAS  PubMed  Google Scholar 

Pape K, Tamouza R, Leboyer M, Zipp F. Immunoneuropsychiatry - novel perspectives on brain disorders. Nat Rev Neurol. 2019;15(6):317–28.

Article  PubMed  Google Scholar 

Fillman SG, Cloonan N, Catts VS, Miller LC, Wong J, McCrossin T, et al. Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol Psychiatry. 2013;18(2):206–14.

Article  CAS  PubMed  Google Scholar 

Wang D, Wang Y, Chen Y, Yu L, Wu Z, Liu R, et al. Differences in inflammatory marker profiles and cognitive functioning between deficit and nondeficit schizophrenia. Front Immunol. 2022;13:958972.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohammadi A, Rashidi E, Amooeian VG. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry Res. 2018;265:25–38.

Article  CAS  PubMed  Google Scholar 

Lesh TA, Careaga M, Rose DR, McAllister AK, Van de Water J, Carter CS, et al. Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms. J Neuroinflammation. 2018;15(1):165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Söderlund J, Schröder J, Nordin C, Samuelsson M, Walther-Jallow L, Karlsson H, et al. Activation of brain interleukin-1beta in schizophrenia. Mol Psychiatry. 2009;14(12):1069–71.

Article  PubMed  PubMed Central  Google Scholar 

Najjar S, Pearlman DM. Neuroinflammation and white matter pathology in schizophrenia: systematic review. Schizophr Res. 2015;161(1):102–12.

Article  PubMed  Google Scholar 

Li H, Chen W, Gou M, Li W, Tong J, Zhou Y, et al. The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia. Front Psychiatry. 2022;13:966657.

Article  PubMed  PubMed Central  Google Scholar 

Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008;9(1):46–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsai SJ. Effects of interleukin-1beta polymorphisms on brain function and behavior in healthy and psychiatric disease conditions. Cytokine Growth Factor Rev. 2017;37:89–97.

Article  CAS  PubMed  Google Scholar 

Kim HK, Andreazza AC, Elmi N, Chen W, Young LT. Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: a potential mediator between mitochondria and immune-activation. J Psychiatr Res. 2016;72:43–50.

Article  PubMed  Google Scholar 

Zhang C, Sajith AM, Xu X, Jiang J, Phillip Bowen J, Kulkarni A, et al. Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation. Bioorg Med Chem. 2022;58:116645.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKenzie BA, Mamik MK, Saito LB, Boghozian R, Monaco MC, Major EO, et al. Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis. Proc Natl Acad Sci U S A. 2018;115(26):E6065–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Srivastava A, Dada O, Qian J, Al-Chalabi N, Fatemi AB, Gerretsen P, et al. Epigenetics of schizophrenia. Psychiatry Res. 2021;305:114218.

Article  CAS  PubMed  Google Scholar 

van den Berg MMJ, Krauskopf J, Ramaekers JG, Kleinjans JCS, Prickaerts J, Briedé JJ. Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders. Prog Neurobiol. 2020;185:101732.

Article  PubMed  Google Scholar 

Thomas KT, Zakharenko SS. MicroRNAs in the onset of schizophrenia. Cells. 2021;10(10):2679.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akkouh IA, Hughes T, Steen VM, Glover JC, Andreassen OA, Djurovic S, et al. Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia. Brain Behav Immun. 2021;94:235–44.

Article  CAS  PubMed  Google Scholar 

Li Y, Song W, Tong Y, Zhang X, Zhao J, Gao X, et al. Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis. J Neuroinflammation. 2021;18(1):1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Voet S, Srinivasan S, Lamkanfi M, van Loo G. Inflammasomes in neuroinflammatory and neurodegenerative diseases. EMBO Mol Med. 2019;11(6):e10248.

Article  PubMed  PubMed Central  Google Scholar 

Konsman JP, Parnet P, Dantzer R. Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci. 2002;25(3):154–9.

Article  CAS  PubMed  Google Scholar 

Falcone T, Carlton E, Lee C, Janigro M, Fazio V, Forcen FE, et al. Does systemic inflammation play a role in pediatric psychosis? Clin Schizophr Relat Psychoses. 2015;9(2):65–78b.

Article  PubMed  Google Scholar 

Ashdown H, Dumont Y, Ng M, Poole S, Boksa P, Luheshi GN. The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia. Mol Psychiatry. 2006;11(1):47–55.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Catts VS, Sheedy D, McCrossin T, Kril JJ, Shannon WC. Cortical grey matter volume reduction in people with schizophrenia is associated with neuro-inflammation. Transl Psychiatry. 2016;6(12):e982.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fillman SG, Weickert TW, Lenroot RK, Catts SV, Bruggemann JM, Catts VS, et al. Elevated peripheral cytokines characterize a subgroup of people with schizophrenia displaying poor verbal fluency and reduced Broca’s area volume. Mol Psychiatry. 2016;21(8):1090–8.

Article  CAS  PubMed  Google Scholar 

Tambuyzer BR, Ponsaerts P, Nouwen EJ. Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol. 2009;85(3):352–70.

Article  CAS  PubMed  Google Scholar 

Williamson LL, Sholar PW, Mistry RS, Smith SH, Bilbo SD. Microglia and memory: modulation by early-life infection. J Neurosci. 2011;31(43):15511–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gonzalez PV, Schiöth HB, Lasaga M, Scimonelli TN. Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. Brain Behav Immun. 2009;23(6):817–22.

Article  CAS  PubMed  Google Scholar 

Prieto GA, Tong L, Smith ED, Cotman CW. TNFα and IL-1β but not IL-18 suppresses hippocampal long-term potentiation directly at the synapse. Neurochem Res. 2019;44(1):49–60.

Article  CAS  PubMed  Google Scholar 

Pirozhkov SV, Terebilina NN, Litvitskiy PF. A role of inflammasomes in the pathogenesis of neurological and mental diseases. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(12):81–91.

Article  CAS  PubMed  Google Scholar 

Zanelli J, Reichenberg A, Sandin S, Morgan C, Dazzan P, Pilecka I, et al. Dynamic and static cognitive deficits in schizophrenia and bipolar disorder after the first episode. Schizophr Bull. 2022;48(3):590–8.

Article  PubMed  PubMed Central  Google Scholar 

Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016;21(12):1696–709.

Article  CAS  PubMed  PubMed Central  Google Scholar