Rosen JM, Roarty K. Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? Breast Cancer Research. 2014;16:202.
Article PubMed PubMed Central Google Scholar
Brown SB, Hankinson SE. Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers. Steroids. 2015;99:8–10.
Article CAS PubMed Google Scholar
Schneider J, Martín-Gutiérrez S, Tresguerres JA, García-Velasco JA. Circulating estradiol defines the tumor phenotype in menopausal breast cancer patients. Maturitas. 2009;64:43–5.
Article CAS PubMed Google Scholar
Obradović MMS, Hamelin B, Manevski N, Couto JP, Sethi A, Coissieux MM, et al. Glucocorticoids promote breast cancer metastasis. Nature. 2019;567:540–4.
Giulianelli S, Lamb CA, Lanari C. Progesterone receptors in normal breast development and breast cancer. Essays in Biochemistry. 2021;65:951–69.
Article CAS PubMed Google Scholar
Michmerhuizen AR, Spratt DE, Pierce LJ, Speers CW. ARe we there yet? Understanding androgen receptor signaling in breast cancer. NPJ Breast Cancer. 2020;6:47.
Article CAS PubMed PubMed Central Google Scholar
Noureddine LM, Trédan O, Hussein N, Badran B, Le Romancer M, Poulard C. Glucocorticoid Receptor: A Multifaceted Actor in Breast Cancer. International Journal of Molecular Sciences. 2021;22:4446.
Article CAS PubMed PubMed Central Google Scholar
Font-Díaz J, Jiménez-Panizo A, Caelles C, Vivanco M dM, Pérez P, Aranda A, et al. Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development. Semin Cancer Biol. 2021;73:58–75.
Pan H, Gray R, Braybrooke J, Davies C, Taylor C, McGale P, et al. 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. The New England Journal of Medicine. 2017;377:1836–46.
Article PubMed PubMed Central Google Scholar
Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, et al. Generation of a functional mammary gland from a single stem cell. Nature. 2006;439:84–8.
Article CAS PubMed Google Scholar
Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, et al. Purification and unique properties of mammary epithelial stem cells. Nature. 2006;439:993–7.
Article CAS PubMed Google Scholar
Hannezo E, Scheele CLGJ, Moad M, Drogo N, Heer R, Sampogna RV, et al. A Unifying Theory of Branching Morphogenesis. Cell. 2017;171:242-255.e27.
Article CAS PubMed PubMed Central Google Scholar
Simões BM, Piva M, Iriondo O, Comaills V, López-Ruiz JA, Zabalza I, et al. Effects of estrogen on the proportion of stem cells in the breast. Breast Cancer Research and Treatment. 2011;129:23–35.
Shehata M, van Amerongen R, Zeeman AL, Giraddi RR, Stingl J. The influence of tamoxifen on normal mouse mammary gland homeostasis. Breast Cancer Research. 2014;16:411.
Article PubMed PubMed Central Google Scholar
Rios AC, Fu NY, Lindeman GJ, Visvader JE. In situ identification of bipotent stem cells in the mammary gland. Nature. 2014;506:322–7.
Article CAS PubMed Google Scholar
Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, et al. Distinct stem cells contribute to mammary gland development and maintenance. Nature. 2011;479:189–93.
van Amerongen R, Bowman AN, Nusse R. Developmental stage and time dictate the fate of Wnt/beta-catenin-responsive stem cells in the mammary gland. Cell Stem Cell. 2012;11:387–400.
Šale S, Lafkas D, Artavanis-Tsakonas S. Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages. Nature Cell Biology. 2013;15:451–60.
Article PubMed PubMed Central Google Scholar
Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H, Fre S. Notch3 marks clonogenic mammary luminal progenitor cells in vivo. The Journal of Cell Biology. 2013;203:47–56.
Article CAS PubMed PubMed Central Google Scholar
Wuidart A, Ousset M, Rulands S, Simons BD, Van Keymeulen A, Blanpain C. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. Genes & Development. 2016;30:1261–77.
Scheele CLGJ, Hannezo E, Muraro MJ, Zomer A, Langedijk NSM, Van Oudenaarden A, et al. Identity and dynamics of mammary stem cells during branching morphogenesis. Nature. 2017;542:313–7.
Article CAS PubMed PubMed Central Google Scholar
Wang D, Cai C, Dong X, Yu QC, Zhang XO, Yang L, et al. Identification of multipotent mammary stemcells by protein C receptor expression. Nature. 2015;517:81–4.
Article CAS PubMed Google Scholar
Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, et al. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nature Communications. 2018;9:2028.
Article PubMed PubMed Central Google Scholar
Kumar B, Prasad M, Bhat-Nakshatri P, Anjanappa M, Kalra M, Marino N, et al. Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade. Cancer Research. 2018;78:5107–23.
Article CAS PubMed PubMed Central Google Scholar
Wang C, Christin JR, Oktay MH, Guo W. Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages. Cell Reports. 2017;18:2825–35.
Article CAS PubMed Google Scholar
Van Keymeulen A, Fioramonti M, Centonze A, Bouvencourt G, Achouri Y, Blanpain C. Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage. Cell Reports. 2017;20:1525–32.
Lloyd-Lewis B, Davis FM, Harris OB, Hitchcock JR, Watson CJ. Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells. Development. 2018;145:dev164079.
Davis FM, Lloyd-Lewis B, Harris OB, Kozar S, Winton DJ, Muresan L, et al. Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny. Nature Communications. 2016;7:13053.
Article CAS PubMed PubMed Central Google Scholar
Rodilla V, Dasti A, Huyghe M, Lafkas D, Laurent C, Reyal F, et al. Luminal progenitors restrict their lineage potential during mammary gland development. PLoS Biology. 2015;13.
Article PubMed PubMed Central Google Scholar
Centonze A, Lin S, Tika E, Sifrim A, Fioramonti M, Malfait M, et al. Heterotypic cell–cell communication regulates glandular stem cell multipotency. Nature. 2020;584(7822):608–13.
Benítez S, Cordero A, Santamaría PG, Redondo-Pedraza J, Rocha AS, Collado-Solé A, et al. RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness. Developmental Cell. 2021;56:1727-1741.e7.
Article PubMed PubMed Central Google Scholar
Koren S, Reavie L, Couto JP, De Silva D, Stadler MB, Roloff T, et al. PIK3CAH1047R induces multipotency and multi-lineage mammary tumours. Nature. 2015;525:114–8.
Article CAS PubMed Google Scholar
Van Keymeulen A, Lee MY, Ousset M, Brohée S, Rorive S, Giraddi RR, et al. Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. Nature. 2015;525:119–23.
Lilja AM, Rodilla V, Huyghe M, Hannezo E, Landragin C, Renaud O, et al. Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland. Nature Cell Biology. 2018;20:677–87.
Article CAS PubMed PubMed Central Google Scholar
Fridriksdottir AJ, Villadsen R, Morsing M, Klitgaard MC, Kim J, Petersen OW, et al. Proof of region-specific multipotent progenitors in human breast epithelia. Proceedings of the National academy of Sciences of the United States of America. 2017;114:E10102–11.
CAS PubMed PubMed Central Google Scholar
Cereser B, Jansen M, Austin E, Elia G, McFarlane T, van Deurzen CHM, et al. Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells. The Journal of Pathology. 2018;244:61–70.
Article CAS PubMed Google Scholar
Palafox M, Ferrer I, Pellegrini P, Vila S, Hernandez-Ortega S, Urruticoechea A, et al. RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis. Cancer Research. 2012;72:2879–88.
Article CAS PubMed Google Scholar
Liu S, Cong Y, Wang D, Sun Y, Deng L, Liu Y, et al. Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts. Stem Cell Rep. 2014;2:78–91.
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