Aloe L, Rocco ML, Bianchi P, Manni L (2012) Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med 10:239
Article CAS PubMed PubMed Central Google Scholar
Ball DK, Surveyor GA, Diehl JR, Steffen CL, Uzumcu M, Mirando MA, Brigstock DR (1998) Characterization of 16- to 20- kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal flushings. Biol Reprod 59:828–835
Article CAS PubMed Google Scholar
Bleau AM, Planque N, Lazar N, Zambelli D, Ori A, Quan T, Fisher G, Scotlandi K, Perbal B (2007) Antiproliferative activity of CCN3: involvement of the C-terminal module and post-translational regulation. J Cell Biochem 101:1475–1491
Article CAS PubMed Google Scholar
Bork P (1993) The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 327:125–130
Article CAS PubMed Google Scholar
Brigstock DR, Steffen CL, Kim GY, Vegunta RK, Diehl JR, Harding PA (1997) Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J Biol Chem 272:20275–20282
Article CAS PubMed Google Scholar
Brigstock DR (1999) The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 20:189–206
Del Caño-Ochoa F, Ramón-Maiques S (2021) Deciphering CAD: structure and function of a mega-enzymatic pyrimidine factory in health and disease. Prot Sci 30:1995–2008
Fenton AW (2008) Allostery: an illustrated definition for the ‘second secret of life.’ Trends Biochem Sci 33:420–425
Article CAS PubMed PubMed Central Google Scholar
Furlan M (1996) Von Willebrand factor: molecular size and functional activity. Ann Hematol 72:341–348
Article CAS PubMed Google Scholar
Garrett EC, Bielawski AM, Ruchti E, Sherer LM, Waghmare I, Hess-Homeier D, McCabe BD, Stowers RS, Certel SJ (2023) The matricellular protein drosophila cellular communication network factor is required for synaptic transmission and female fertility. Genet Adv
Herpin A, Lelong C, Favrel P (2004) Transforming growth factor-beta-related proteins: an ancestral and widespread superfamily of cytokines in metazoans. Dev Comp Immunol 28:461–485
Article CAS PubMed Google Scholar
Holbourn KP, Perbal B, Acharya KR (2009) Proteins on the catwalk: modelling the structural domains of the CCN family of proteins. J Cell Commun Signal 3:25–41
Article PubMed PubMed Central Google Scholar
Holmes DI, Zachary I (2005) The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol 6:209–210
Article PubMed PubMed Central Google Scholar
Hwa V, Oh Y, Rosenfeld RG (1999) The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev 20:761–787
Hu K, Tao Y, Li J, Liu Z, Zhu X, Wang Z (2019) A comparative genomic and phylogenetic analysis of the origin and evolution of the CCN gene family. Biomed Res Int 19:8620878
Iyer S, Acharya KR (2011) Tying the knot: the cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines. FEBS J 278:4304–4322
Article CAS PubMed PubMed Central Google Scholar
Joliot V, Martinerie C, Dambrine G, Plassiart G, Brisac M, Crochet J, Perbal B (1992) Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1- induced nephroblastomas. Mol Cell Biol 12:10–21
CAS PubMed PubMed Central Google Scholar
Kaasbøll OJ, Gadicherla AK, Wang JH, Monsen VT, Hagelin EMV, Dong MQ, Attramadal H (2018) Connective tissue growth factor (CCN2) is a matricellular preproprotein controlled by proteolytic activation. J Biol Chem 293:17953–17970
Article PubMed PubMed Central Google Scholar
Lacroute F (1968) Regulation of pyrimidine biosynthesis in saccharomyces cerevisiae. J Bact 95:824–832
Article CAS PubMed PubMed Central Google Scholar
Lau LF, Lam SC (1999) The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 248:44–57
Article CAS PubMed Google Scholar
Lau LF (2016) Cell surface receptors for CCN proteins. J Cell Commun Signal 10:121–127
Article PubMed PubMed Central Google Scholar
Lazar N, Manara C, Navarro S, Bleau AM, Llombart-Bosch A, Scotlandi K, Planque N, Perbal B (2007) Domain-specific CCN3 antibodies as unique tools for structural and functional studies. J Cell Commun Signal 1:91–102
Article PubMed PubMed Central Google Scholar
Lunenfeld B (2004) Historical perspectives in gonadotrophin therapy. Hum Reprod Update 10:453–467
Article CAS PubMed Google Scholar
Meng X, Nikolic-Paterson DJ, Lan HY (2016) TGF-β: the master regulator of fibrosis. Nat Rev Nephrol 12:325–338
Article CAS PubMed Google Scholar
Monod J, Changeux JP, Jacob F (1963) Allosteric proteins and cellular control systems. J Mol Biol 6:306–329
Article CAS PubMed Google Scholar
Morlon H (2014) Phylogenetic approaches for studying diversification. Ecol Lett. https://doi.org/10.1111/ele.12251
Perbal B (1999) Nuclear localization of NOV protein: a potential role for nov in the regulation of gene expression. Mol Pathol 52:84–91
Article CAS PubMed PubMed Central Google Scholar
Perbal B (2001) NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol 54:57–79
Article CAS PubMed PubMed Central Google Scholar
Perbal B (2004) CCN proteins: multifunctional signalling regulators. Lancet 363:62–64
Article CAS PubMed Google Scholar
Perbal B (2009) Alternative splicing of CCN mRNAs it has been upon us. J Cell Commun Signal 3:153–157
Article PubMed PubMed Central Google Scholar
Perbal B (2013) CCN proteins: a centralized communication network. J Cell Commun Signal 7:169–177
Article PubMed PubMed Central Google Scholar
Perbal B (2018) The concept of the CCN protein family revisited: a centralized coordination network. J Cell Commun Signal 12:3–12
Article PubMed PubMed Central Google Scholar
Perbal B (2019) CCN proteins are part of a multilayer complex system: a working model. J Cell Commun Signal 13:437–439
Article PubMed PubMed Central Google Scholar
Perbal B (2023) Time has come to address the spatiotemporal combinatorial model for CCN proteins biological activitites by spatial transcriptomics and genome wide association studies. J Cell Commun Signal 8:1–3
Perbal B, Tweedie S, Bruford E (2018) The official unified nomenclature adopted by the HGNC calls for the use of the acronyms, CCN1–6, and discontinuation in the use of CYR61, CTGF, NOV and WISP 1–3 respectively. J Cell Commun Signal 12:625–629
Article PubMed PubMed Central Google Scholar
Planque N, Perbal B (2003) A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis. Cancer Cell Int 3(1):15
Article PubMed PubMed Central Google Scholar
Richard D, Liu Z, Cao J, Kiapour AM, Willen J, Yarlagadda S, Jagoda E, Kolachalama VB, Sieker JT, Chang GH, Muthuirulan P, Young M, Masson A, Konrad J, Hosseinzadeh S, Maridas DE, Rosen V, Krawetz R, Roach N, Capellini TD (2020) Evolutionary selection and constraint on human knee chondrocyte regulation impacts osteoarthritis risk. Cell 181:362–381
Article CAS PubMed PubMed Central Google Scholar
Rittié L, Perbal B, Castellot JJ Jr, Orringer JS, Voorhees JJ, Fisher GJ (2011) Spatial-temporal modulation of CCN proteins during wound healing in human skin in vivo. J Cell Commun Signal 5:69–80
Article PubMed PubMed Central Google Scholar
Roschger C, Cabrele C (2017) The Id-protein family in developmental and cancer-associated pathways. Cell Commun Signal 15(1):7
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