Yuan J, Yang J, Zhuang Z, Yang Y, Lin L, Wang S. Thrombolytic effects of Douchi Fibrinolytic enzyme from Bacillus subtilis LD-8547 in vitro and in vivo. BMC Biotechnol. 2012;2012(12):36.
Taneja K, Bajaj BK, Kumar S, Dilbaghi N. Production, purification and characterization of fibrinolytic enzyme from Serratia sp. KG-2-1 using optimized media. 3 Biotech. 2017;7(3):184.
Article PubMed PubMed Central Google Scholar
Chung DM, Choi NS, Chun HK, Maeng PJ, Park SB, Kim SH. A new fibrinolytic enzyme (55 kDa) from Allium tuberosum: purification, characterization, and comparison. J Med Food. 2010;13:1532–6.
Article CAS PubMed Google Scholar
Huang MX, Ye Y, Chen YX, Han YL. Partial purification and characterization of fibrinolytic enzymes from yellow mealworm. Int J Pept Res Ther. 2012;18:153–61.
Ju X, Cao X, Sun Y, Wang Z, Cao C, Liu J, Jiang J. Purification and characterization of a fibrinolytic enzyme from Streptomyces sp. XZNUM 00004. World J Microbiol Biotechnol. 2012;28:2479–86.
Article CAS PubMed Google Scholar
Dharmawati IGAA, Mahadewa TGB, Widyadharma IPE. Antibacterial activity of Lumbricus rubellus earthworm extract against Porphyromonas gingivalis as the bacterial cause of periodontis. Maced J Med Sci. 2019;7(6):1032–6.
Wang YH, Chen KM, Chiu PS, Lai SC, Su HH, Jan MS, Lin CW, Lu DY, Fu YT, Liao JM, Chang JT, Huang SS. Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling. J Mol Cell Cardiol. 2016;99:113–22.
Article CAS PubMed Google Scholar
Samatra DPGP, Tjokorda GBM, Sukrama DMI, Dewi NYS, Praja RK, Nurmansyah D. Widyadharma IPE. Extract of earthworms (Lumbricus rubellus) reduced malondialdehyde and 8-hydroxy-deoxyguanosine level in male Wistar rats infected by Salmonella typhi. Biomed Pharmacol J. 2017;10(4):1765–71.
Permana S, Hadi RP, Norahmawati E, Endharti AT. Coelomic fluid of Lumbricus rubellus enhances anti-prolioniferative effect of 5-fluorouracil by modulating focal adhesion kinase express and IL-1β of colorectal cancer in mice. J Appl Pharm Sci. 2019;9(08):041–6.
Ozkan AD, Eskiler GG, Sarihan M, Kazan N, Aksoy O, Yuksel B, Betts Z. Anticancer properties of Eisenia foetida proteins in prostate cancer cells in vitro. Int J Pept Res Ther. 2022;28:119.
Liu CM, Chen XT, Pan YY, Liang H, Song SL, Ji AG. Antitumor studies of earthworms fibrinolytic enzyme component A from Eisenia foetida on breast cancer cell line MCF-7. Indian J Pharm Sci. 2017;79(3):361–8.
Lannuci NB, Camperi SA, Cascone O. Purification of enzymes from earthworms. Dynam Soil Dynam Plant. 2009;3(Special issue 2):64–8.
Lee CK, Shin JS, Kim BS, Cho IH, Kim YS, Lee EB. Antithrombotic effects by oral administration ofnovel proteinase from earthworm Eisenia andrei on venous thrombosis model in rats. Archives Pharmacal Res. 2007;30:475–80.
Thuy LTB, Tuyen ET, Dao NTN. Purification and identification of some characters of the fibrinolytic enzyme isolated from the earthworm Perionyx excavatus. Biology Magazine (Vietnam). 2006;2006(28):77–82.
Fan Q, Wu C, Li L, et al. Some features of intestinal absorption of intact fibrinolytic enzyme III-1 from Lumbricus rubellus. Biochim Biophys Acta. 2001;1526(3):286–92.
Article CAS PubMed Google Scholar
Cooper EL, Ru B, Weng N. Earthworms: sources of antimicrobial and anticancer molecules. Adv in Experiment Med Biol. 2004;546:359–89.
Chen H, Takahasi S, Imamura M. Earthworm fibrinolytic enzyme: anti-tumor activity on human hepatoma cells in vitro and in vivo. Chin Med J. 2007;120:898–904.
Article CAS PubMed Google Scholar
Verma MK, Pulicherla KK. Enzyme promiscuity in earthworm serine protease: substrate versatility and therapeutic potential. Amino acid. 2016;48:941–8.
Wei S, Yin X, Kou Y, Jiang B. Lumbricus extract promotes the regeneration of injured peripheral nerve in rats. J Ethnopharm. 2009;123:51–4.
Trisina J, Sunardi F, Suhartono MT, Raymond R, Tjandrawinata RR. DLBS1033, a protein extract from Lumbricus rubellus, possesses antithrombotic and thrombolytic activities. J Biomed Biotechnol. 2011;2011:1–8.
Tjandrawinata RR, Trisina J, Rahayu P, Prasetya LA, Hanafiah A, Rachmawaty H. Bioactive protein fraction DLBS1033 containing lumbrokinase isolated from Lumbricuss rubellus: ex vivo, in vivo, and pharmaceutic studies. Drug Des Dev Ther. 2014;8:1585–93.
Gayatri A, Nafrialdi N, Setiabudy RD, Tjandrawinata RR, Rachman A, Louisa M. A Clinical trial on biological half life of bioactive protein from Lumbricus rubellus, DLBS1033 in healthy volunteers. Indones J Intern Med. 2018;50(3):208–14.
Christy G, Tjandrawinata RR, Rachmawati H. Tabletting process of pellets containing bioactive fraction DLBS1033F isolated from Lumbricus rubellus: challenge and strategy. Bio Pharm Bull. 2015;38(12):1843–9.
Laemmli UK. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–5.
Article CAS PubMed Google Scholar
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin-Phenol reagents. J Biol Chem. 1951;193:265–75.
Article CAS PubMed Google Scholar
Bringans S, Eriksen S, Kendrick T, Gopalakrishnakone P, Livk A, Lock R. Proteomic analyses of the venom of Heterometruslongimanus (Asian black scorpion). Proteomics. 2008;8:1081–96.
Article CAS PubMed Google Scholar
Phan TT, Ta TD, Nguyen DT, Van Den Broek LA, Duong GT. Purification and characterization of novel fibrinolytic proteases as potential antithrombotic agents from earthworm Perionyx excavatus. AMB Express. 2011;1(1):26.
Article PubMed PubMed Central Google Scholar
Wang F, Wang G, Li M, Cui L, Zhan J, Chang W. Purification, characterization and crystallization of a group of earthworm fibrinolytic enzymes from Eisenia foetida. Biotechnol Lett. 2003;25:1105–9.
Article CAS PubMed Google Scholar
Biron DG, Brun C, Lefevre T, Lebarbenchon C, Loxdale HD, Chevenet F, Brizard JP, Thomas F. The pitfalls of proteomics experiments without the correct use of bioinformatics tools. Proteomics. 2006;6:5577–96.
Article CAS PubMed Google Scholar
Damodaran S, Wood TD, Nagarajan P, Rabin R. Evaluating peptide mass fingerprinting-based protein identification. Geno Prot Bioinfo. 2007;5:3–4.
Barret J, Brophy PM, Hamilton JV. Analysing proteomic data. Int J Parasitol. 2005;35(5):543–53.
Garza S, Moini M. Analysis of complex protein mixtures with improved sequence coverage using (CE-MS/MS). Anal Chem. 2006;78(20):7309–16.
Article CAS PubMed Google Scholar
Salzano AM, Crescenzi M. Mass spectrometry to protein identification and the study of post translational modifications. Ann Ist super Sanita. 2005;41(4):443–50.
Mirsaeidi M, Gidfar S, Schraufnagel D. Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis. J Transl Med. 2016;14:89.
Article PubMed PubMed Central Google Scholar
Tjandrawinata RR, Yunaidi DA, Susanto LW. The safety and tolerability of lumbrokinase DLBS1033 in healthy adult subjects. Drug Res. 2016;66(6):293–9.
Setyopranoto I, Wibowo S, Tjandrawinata RR. Hemostasis profile and clinical outcome of acute ischemic stroke patients treated with oral lumbrokinase DLBS1033: a comparative study versus aspirin and clopidogrel. Asian J Pharm Clin Res. 2016;9(1):171–7.
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