Immunohistochemical markers of prognosis in adult granulosa cell tumors of the ovary – a review

Foulkes WD, Gore M, et al. Rare non-epithelial ovarian neoplasms: pathology, genetics and treatment. Gynecol Oncol. 2016;142(1):190–8.

Article  CAS  PubMed  Google Scholar 

Kota SK, Gayatri K, et al. Ovarian granulosa cell tumor: an uncommon presentation with primary amenorrhea and virilization in a pubertal girl. Indian J Endocrinol Metab. 2012;16(5):836–9.

Article  PubMed  PubMed Central  Google Scholar 

Adefris M, Fekadu E. Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report. J Med Case Rep. 2017;11(1):242.

Article  PubMed  PubMed Central  Google Scholar 

Kommoss F, Lehr HA. Sex cord-stromal tumors of the ovary : current aspects with a focus on granulosa cell tumors, Sertoli-Leydig cell tumors, and gynandroblastomas. Pathologe. 2019;40(1):61–72.

Article  CAS  PubMed  Google Scholar 

Jamieson S, Fuller PJ. Molecular pathogenesis of granulosa cell tumors of the ovary. Endocr Rev. 2012;33(1):109–44.

Article  CAS  PubMed  Google Scholar 

Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft DK, AWMF). S3-Leitlinie Diagnostik, Therapie und Nachsorge maligner Ovarialtumoren. Langversion 50, 2021, AWMF-Registernummer: 032/035OL, https://www.leitlinienprogramm-onkologie.de/leitlinien/ovarialkarzinom/, [Download 2022/02/03].

Colombo N, Peiretti M, et al. Non-epithelial ovarian cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23 (Suppl 7):vii20–6.

Seagle BL, Ann P, et al. Ovarian granulosa cell tumor: a National Cancer Database study. Gynecol Oncol. 2017;146(2):285–91.

Article  PubMed  Google Scholar 

Sehouli J, Drescher FS, et al. Granulosa cell tumor of the ovary: 10 years follow-up data of 65 patients. Anticancer Res. 2004;24:1223–30.

PubMed  Google Scholar 

Mangili G, Ottolina J, et al. Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary. Br J Cancer. 2013;109(1):29–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levin G, Zigron R, et al. Granulosa cell tumor of ovary: a systematic review of recent evidence. Eur J Obstet Gynecol Reprod Biol. 2018;225:57–61.

Article  PubMed  Google Scholar 

Van Diest PJ, Baak JPA, et al. Reproducibility of mitosis counting in 2,469 breast Cancer specimens: results from the multicenter morphometric mammary carcinoma project. Hum Pathol. 1992;23(6):603–7.

Article  PubMed  Google Scholar 

McCluggage WG, Singh N, et al. Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020). Histopathology. 2022;80(5):762–78.

Article  PubMed  Google Scholar 

Malmström H, Högberg T, et al. Granulosa cell tumors of the ovary: prognostic factors and outcome. Gynecol Oncol. 1994;52:50–5.

Article  PubMed  Google Scholar 

King LA, Okagaki T, et al. Mitotic count, nuclear atypia, and Immunohistochemical determination of Ki-67, c-myc, p21-ras, c-erbB2, and p53 expression in granulosa cell tumors of the ovary: mitotic count and Ki-67 are indicators of poor prognosis. Gynecol Oncol. 1996;61:227–32.

Article  CAS  PubMed  Google Scholar 

Fujimoto T, Sakuragi N, et al. Histopathological prognostic factors of adult granulosa cell tumors of the ovary. Acta Obstet Gynecol Scand. 2001;80:1069–74.

Article  CAS  PubMed  Google Scholar 

van Meurs HS, Schuit E, et al. Development and internal validation of a prognostic model to predict recurrence free survival in patients with adult granulosa cell tumors of the ovary. Gynecol Oncol. 2014;134(3):498–504.

Article  PubMed  Google Scholar 

Thomakos N, Biliatis I, et al. Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. Arch Gynecol Obstet. 2016;294(5):1031–6.

Article  PubMed  Google Scholar 

Sakr S, Abdulfatah E, et al. Granulosa cell tumors: novel predictors of recurrence in early-stage patients. Int J Gynecol Pathol. 2017;36(3):240–52.

Article  PubMed  PubMed Central  Google Scholar 

Dridi M, Chraiet N, et al. Granulosa cell tumor of the ovary: a retrospective study of 31 cases and a review of the literature. Int J Surg Oncol. 2018;2018:4547892.

PubMed  PubMed Central  Google Scholar 

Costa MJ, Walls J, et al. Transformation in recurrent ovarian granulosa cell tumors: Ki67 (MIB-1) and p53 Innunohistochemistry demonstrates a possible molecular basis for the poor histopathologic prediction of clinical behavior. Hum Pathol. 1995;27(3):274–81.

Article  Google Scholar 

Lauszus FF, Petersen AC, et al. Granulosa cell tumor of the ovary: a population-based study of 37 women with stage I disease. Gynecol Oncol. 2001;81(3):456–60.

Article  CAS  PubMed  Google Scholar 

Lin YS, Eng HL, et al. Molecular cytogenetics of ovarian granulosa cell tumors by comparative genomic hybridization. Gynecol Oncol. 2005;97(1):68–73.

Article  CAS  PubMed  Google Scholar 

Kim YM, Jung MH, et al. Adult granulosa cell tumor of the ovary: 35 cases in a single Korean institute. Acta Obstet Gynecol Scand. 2006;85(1):112–5.

Article  CAS  PubMed  Google Scholar 

Pectasides D, Papaxoinis G, et al. Adult granulosa cell tumors of the ovary: a Clinicopathological study of 34 patients by the Hellenic cooperative oncology group (HeCOG). Anticancer Res. 2008;28:1421–8.

CAS  PubMed  Google Scholar 

Suri A, Carter EB, et al. Factors associated with an increased risk of recurrence in women with ovarian granulosa cell tumors. Gynecol Oncol. 2013;131(2):321–4.

Article  PubMed  Google Scholar 

Leuverink EM, Brennan BA, et al. Prognostic value of mitotic counts and Ki-67 immunoreactivity in adult-type granulosa cell tumour of the ovary. J Clin Pathol. 2008;61(8):914–9.

Article  CAS  PubMed  Google Scholar 

Gerdes J, Lemke H, et al. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol. 1984;133:1710–5.

Article  CAS  PubMed  Google Scholar 

Balan RA, Caruntu I-D, et al. Immunhistochemical significance of ER alpha, inhibin a, calretinin, and Ki67 expression in granulosa cell ovarian tumors. Romanian J Morphol Embryol. 2017;58(3):753–60.

Google Scholar 

Mayr D, Kaltz-Wittmer C, et al. Characteristic pattern of genetic aberrations in ovarian granulosa cell tumors. Mod Pathol. 2002;15(9):951–7.

Article  CAS  PubMed  Google Scholar 

Horny H-P, Marx L, et al. Granulosa cell tumor of the ovary. Gynecol Obstet Investig. 1999;47:133–8.

Article  CAS  Google Scholar 

Stewart CJ, Brennan BA, et al. Comparison of proliferation indices in primary adult-type granulosa cell tumors of the ovary and their corresponding metastases: an analysis of cases. Int J Gynecol Pathol. 2009;28(5):423–431.

Soussi T, Wiman KG. TP53: an oncogene in disguise. Cell Death Differ. 2015;22(8):1239–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jensen RA, Page DL. p53: the promising story continues to unfold. Hum Pathol. 1993;24(5):455–6.

Article  CAS  PubMed  Google Scholar 

Ala-Fossi S-L, Mäenpää J, et al. Prognostic significance of p53 expression in ovarian granulosa cell tumors. Gynecol Oncol. 1997;66:475–9.

Article  CAS  PubMed  Google Scholar 

Gebhart JB, Roche PC, et al. Assessment of inhibin and p53 in granulosa cell tumors of the ovary. Gynecol Oncol. 2000;77(2):232–6.

Article  CAS  PubMed  Google Scholar 

Staibano S, Franco R, et al. Loss of oestrogen receptor beta, high PCNA and p53 expression and aneuploidy as markers of worse prognosis in ovarian granulosa cell tumours. Histopathology. 2003;43:254–62.

Article  CAS  PubMed  Google Scholar 

Kusamura S, Derchain S, et al. Expression of p53, c-erbB-2, Ki-67, and CD34 in granulosa cell tumor of the ovary. Int J Gynecol Cancer. 2003;13(4):450–7.

Article  CAS  PubMed  Google Scholar 

Liu F-S, Ho ES-C, et al. Overexpression of p53 is not a feature of ovarian granulosa cell tumors. Gynecol Oncol. 1996;61:50–3.

Article  CAS  PubMed  Google Scholar 

Singh N, Piskorz AM, et al. p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies. J Pathol. 2020;250(3):336–45.

Article  CAS  PubMed  Google Scholar 

Roze J, Monroe G, et al. Whole genome analysis of ovarian granulosa cell tumors reveals tumor heterogeneity and a high-grade TP53-specific subgroup. Cancers (Basel). 2020;12(5):1308.

Thiery J-P, Duband J-L, et al. Cell adhesion molecules in early chicken embryogenesis. Neurobiology. 1982;79:6737–41.

CAS  Google Scholar 

Mayerhofer A, Lahr G, et al. Expression and alternative splicing of the neural cell adhesion molecule NCAM in human granulosa cells during luteinization. FEBS Lett. 1994;346:207–12.

Article  CAS 

留言 (0)

沒有登入
gif