Health-Europe TL. Polycystic ovary syndrome: what more can be done for patients? Lancet Reg Health Eur. 2022;21:100524. https://doi.org/10.1016/j.lanepe.2022.100524.
Kshetrimayum C, Sharma A, Mishra VV, Kumar S. Polycystic ovarian syndrome: Environmental/occupational, lifestyle factors; an overview. J Turk Ger Gynecol Assoc. 2019;20(4):255. https://doi.org/10.4274/jtgga.galenos.2019.2018.0142.
Article CAS PubMed PubMed Central Google Scholar
Zhai Y, Pang Y. Systemic and ovarian inflammation in women with polycystic ovary syndrome. J Reprod Immunol. 2022;151: 103628. https://doi.org/10.1016/j.jri.2022.103628.
Article CAS PubMed Google Scholar
Witchel SF, Oberfield SE, Peña AS. Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls. J Endocr Soc. 2019;3(8):1545–73. https://doi.org/10.1210/js.2019-00078.
Article CAS PubMed PubMed Central Google Scholar
Rocha AL, Oliveira FR, Azevedo RC, Silva VA, Peres TM, Candido AL, Gomes KB, Reis FM. Recent advances in the understanding and management of polycystic ovary syndrome. F1000Res. 2019;8. https://doi.org/10.12688/f1000research.15318.1.
Domecq JP, Prutsky G, Mullan RJ, Sundaresh V, Wang AT, Erwin PJ, Welt C, Ehrmann D, Montori VM, Murad MH. Adverse effects of the common treatments for polycystic ovary syndrome: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2013;98(12):4646–54. https://doi.org/10.1210/jc.2013-2374.
Article CAS PubMed PubMed Central Google Scholar
Rashid R, Mir SA, Kareem O, Ali T, Ara R, Malik A, Amin F, Bader GN. Polycystic ovarian syndrome-current pharmacotherapy and clinical implications. Taiwan J Obstet Gynecol. 2022;61(1):40–50. https://doi.org/10.1016/j.tjog.2021.11.009.
Manouchehri A, Abbaszadeh S, Ahmadi M, Nejad FK, Bahmani M, Dastyar N. Polycystic ovaries and herbal remedies: a systematic review. JBRA Assist Reprod. 2023;27(1):85. https://doi.org/10.5935/1518-0557.20220024.
Article PubMed PubMed Central Google Scholar
Ganapaty S, Vidyadhar KN. Phytoconstituents and biological activities of Vitex-a review. J Nat Rremedies. 2005;75–95. https://doi.org/10.18311/jnr/2005/391.
Vishwanathan AS, Basavaraju R. A review on Vitex negundo L.: a medicinally important plant. Eur J Biol Sci. 2010;3(1):30–42.
Zheng CJ, Qin LP. Negundo Chastetree (Vitex negundo) oils. In: Essential oils in Food Preservation, Flavor and Safety. Academic; 2016. p. 601-6.
Kamal N, Mio Asni NS, Rozlan IN, Mohd Azmi MA, Mazlan NW, Mediani A, Baharum SN, Latip J, Assaw S, Edrada-Ebel RA. Traditional Medicinal uses, Phytochemistry, Biological Properties, and Health applications of Vitex Sp. Plants (Basel). 2022;11(15):1944. https://doi.org/10.3390/plants11151944.
Article CAS PubMed Google Scholar
Zheng CJ, Li HQ, Ren SC, Xu CL, Rahman K, Qin LP, Sun YH. Phytochemical and pharmacological profile of Vitex negundo. Phytother Res. 2015;29(5):633–47. https://doi.org/10.1002/ptr.5303.
Kakadia N, Patel P, Deshpande S, Shah G. Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome. J Tradit Complement Med. 2019;9(4):336–45. https://doi.org/10.1016/j.jtcme.2018.03.001.
Shetty DK, Patil S. Studying the Testosterone lowering potential of Vitex negundo (Nirgundi) seed extract in hyperandrogenic female rats Induced with Polycystic ovaries. Int J Pharm Sci Rev Res. 2015;33(1):211–6.
Saiyed A, Jahan N, Makbul SA, Ansari M, Bano H, Habib SH. Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res. 2016;5(4):293–300. https://doi.org/10.1016/j.imr.2016.10.002.
Article PubMed PubMed Central Google Scholar
Glueck CJ, Goldenberg N. Characteristics of obesity in polycystic ovary syndrome: etiology, treatment, and genetics. Metabolism. 2019;92:108–20. https://doi.org/10.1016/j.metabol.2018.11.002.
Article CAS PubMed Google Scholar
Kiddy DS, Sharp PS, White DM, Scanlon MF, Mason HD, Bray CS, Polson DW, Reed MJ, Franks S. Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases. Clin Endocrinol. 1990;32(2):213–20. https://doi.org/10.1111/j.1365-2265.1990.tb00857.x.
Nath CK, Barman B, Das A, Rajkhowa P, Baruah P, Baruah M, Baruah A. Prolactin and thyroid stimulating hormone affecting the pattern of LH/FSH secretion in patients with polycystic ovary syndrome: a hospital-based study from North East India. J Family Med Prim Care. 2019;8(1):256. https://doi.org/10.4103/jfmpc.jfmpc_281_18.
Article PubMed PubMed Central Google Scholar
Lakshmi JN, Babu AN, Kiran SM, Nori LP, Hassan N, Ashames A, Bhandare RR, Shaik AB. Herbs as a source for the treatment of polycystic ovarian syndrome: a systematic review. Biotech. 2023;12(1):4. https://doi.org/10.3390/biotech12010004.
Article CAS PubMed PubMed Central Google Scholar
Brožič P, Kocbek P, Sova M, Kristl J, Martens S, Adamski J, Gobec S, Rižner TL. Flavonoids and cinnamic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Mol Cell Endocrinol. 2009;301(1–2):229–34. https://doi.org/10.1016/j.mce.2008.09.004.
Article CAS PubMed Google Scholar
Arlt W, Neogi P, Gross C, Miller WL. Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004;32(2):425–36. https://doi.org/10.1677/jme.0.0320425.
Article CAS PubMed Google Scholar
Ashraf S, Nabi M, Rashid F, Amin S. Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review. Egypt J Med Hum Genet. 2019;20(1):1–0. https://doi.org/10.1186/s43042-019-0031-4.
Jakimiuk AJ, Weitsman SR, Yen HW, Bogusiewicz M, Magoffin DA. Estrogen receptor α and β expression in theca and granulosa cells from women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87(12):5532–8. https://doi.org/10.1210/jc.2002-020323.
Article CAS PubMed Google Scholar
Roberts AJ, skinner MK. Estrogen regulation of thecal cell steroidogenesis and differentiation: thecal cell-granulosa cell interactions. Endocrinology. 1990;127(6):2918–29. https://doi.org/10.1210/endo-127-6-2918.
Article CAS PubMed Google Scholar
Dey A, Dhadhal S, Maharjan R, Nagar PS, Nampoothiri L. Partially purified non-polar phytocomponents from Aloe barbadensis Mill. Gel restores metabolic and reproductive comorbidities in letrozole-induced polycystic ovary syndrome rodent model-an in-vivo study. J Ethnopharmacol. 2022;291:115161. https://doi.org/10.1016/j.jep.2022.115161.
Article CAS PubMed Google Scholar
Manneras L, Cajander S, Holmäng A, Seleskovic Z, Lystig T, Lönn M, Stener-Victorin E. A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome. Endocrinology. 2007;148(8):3781–91. https://doi.org/10.1210/en.2007-0168.
Article CAS PubMed Google Scholar
Davey RA, Grossmann M. Androgen receptor structure, function and biology: from bench to bedside. Clin Biochem Rev. 2016;37(1):3.
PubMed PubMed Central Google Scholar
Pereira de Jésus-Tran K, Côté PL, Cantin L, Blanchet J, Labrie F, Breton R. Comparison of crystal structures of human androgen receptor ligand‐binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. Protein Sci. 2006;15(5):987–99. https://doi.org/10.1110/ps.051905906.
Article CAS PubMed PubMed Central Google Scholar
Unluhizarci K, Karaca Z, Kelestimur F. Role of insulin and insulin resistance in androgen excess disorders. World J Diabetes. 2021;12(5): 616.
Article PubMed PubMed Central Google Scholar
Adisakwattana S. Cinnamic acid and its derivatives: mechanisms for prevention and management of diabetes and its complications. Nutrients. 2017;9(2): 163. https://doi.org/10.3390/nu9020163.
Article CAS PubMed PubMed Central Google Scholar
Sunil C, Duraipandiyan V, Agastian P, Ignacimuthu S. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2012;50(12):4356–63. https://doi.org/10.1016/j.fct.2012.08.046.
Article CAS PubMed Google Scholar
Zuo T, Zhu M, Xu W. Roles of oxidative stress in polycystic ovary syndrome and cancers. Oxid Med Cell Longev. 2016;2016:8589318. https://doi.org/10.1155/2016/8589318.
Article CAS PubMed Google Scholar
Sun Y, Li S, Liu H, Bai H, Hu K, Zhang R, Liu Q, Fan P. Oxidative stress promotes hyperandrogenism by reducing sex hormone-binding globulin in polycystic ovary syndrome. Fertil Steril. 2021;116(6):1641–50.
Article CAS PubMed Google Scholar
Siemers KM, Klein AK, Baack ML. Mitochondrial dysfunction in PCOS: insights into Reproductive Organ Pathophysiology. Int J Mol Sci. 2023;24(17): 13123. https://doi.org/10.3390/ijms241713123.
Article CAS PubMed PubMed Central Google Scholar
Jahan S, Munir F, Razak S, Mehboob A, Ain QU, Ullah H, Afsar T, Shaheen G, Almajwal A. Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats. J Ovarian Res. 2016;9:1–9. https://doi.org/10.1186/s13048-016-0295-y.
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