Gulati R, Behfar A, Narula J, et al. Acute myocardial infarction in young individuals. Mayo Clin Proc. 2020;1:136–56.

Article  Google Scholar 

Ibáñez B, Heusch G, Ovize M, et al. Evolving therapies for myocardial ischemia/reperfusion injury. J Am Coll Cardiol. 2015;65(14):1454–71.

Article  PubMed  Google Scholar 

Davidson SM, Ferdinandy P, Andreadou I, et al. Multitarget strategies to reduce myocardial ischemia/reperfusion injury: JACC review topic of the week. J Am Coll Cardiol. 2019;73(1):89–99.

Article  PubMed  Google Scholar 

Koopman M, Hetz C, Nollen EAA. Saved by the matrix: UPR independent survival under ER stress. Cell. 2019;179(6):1246–8.

Article  CAS  PubMed  Google Scholar 

Lynch JM, Maillet M, Vanhoutte D, et al. A thrombospondin-dependent pathway for a protective ER stress response. Cell. 2012;149(6):1257–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Anken E, Bakunts A, Hu CA, et al. Molecular evaluation of endoplasmic reticulum homeostasis meets humoral immunity. Trends Cell Biol. 2021;31(7):529–41.

Article  PubMed  PubMed Central  Google Scholar 

Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science. 2011;334(6059):1081–6.

Article  CAS  PubMed  Google Scholar 

Irmler M, Thome M, Hahne M, et al. Inhibition of death receptor signals by cellular FLIP. Nature. 1997;388(6638):190–5.

Article  CAS  PubMed  Google Scholar 

Rasper DM, Vaillancourt JP, Hadano S, et al. Cell death attenuation by “usurpin”, a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death Differ. 1998;5(4):271–88.

Article  CAS  PubMed  Google Scholar 

Muendlein HI, Jetton D, Connolly WM, et al. cFLIP(L) protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation. Science. 2020;367(6484):1379–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marini ES, Giampietri C, Petrungaro S, et al. The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria. Cell Death Differ. 2015;22(7):1131–43.

Article  CAS  PubMed  Google Scholar 

Safa AR. c-FLIP, a master anti-apoptotic regulator [J]. Exp Oncol. 2012;34(3):176–84.

CAS  PubMed  PubMed Central  Google Scholar 

Liu D, Wu H, Li YZ, et al. Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously. Nutr Metab Cardiovasc Dis. 2021;31(6):1916–28.

Article  CAS  PubMed  Google Scholar 

Kavuri SM, Geserick P, Berg D, et al. Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex. J Biol Chem. 2011;286(19):16631–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seyrek K, Ivanisenko NV, Richter M, et al. Controlling cell death through post-translational modifications of DED proteins. Trends Cell Biol. 2020;30(5):354–69.

Article  CAS  PubMed  Google Scholar 

Imanishi T, Murry CE, Reinecke H, et al. Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues. Cardiovasc Res. 2000;48(1):101–10.

Article  CAS  PubMed  Google Scholar 

Martín-Pérez R, Niwa M, López-Rivas A. ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2. Apoptosis. 2012;17(4):349–63.

Article  PubMed  PubMed Central  Google Scholar 

Wang ZV, Deng Y, Gao N, et al. Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway. Cell. 2014;156(6):1179–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiaohong W, Jun Z, Hongmei G, et al. CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress. Biomed Pharmacother. 2019;117:109155.

Article  PubMed  Google Scholar 

Conti S, Petrungaro S, Marini ES, et al. A novel role of c-FLIP protein in regulation of ER stress response. Cell Signal. 2016;28(9):1262–9.

Article  CAS  PubMed  Google Scholar 

Jin J, Blackwood EA, Azizi K, et al. ATF6 decreases myocardial ischemia/reperfusion damage and links er stress and oxidative stress signaling pathways in the heart. Circ Res. 2017;120(5):862–75.

Article  CAS  PubMed  Google Scholar 

Koenig A, Buskiewicz IA, Fortner KA, et al. The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival. J Biol Chem. 2014;289(2):1183–91.

Article  CAS  PubMed  Google Scholar 

Chaudhary PM, Eby MT, Jasmin A, et al. Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene. 2000;19(39):4451–60.

Article  CAS  PubMed  Google Scholar 

Burton JC, Grimsey NJ. Ubiquitination as a key regulator of endosomal signaling by GPCRs. Front Cell Dev Biol. 2019;7:43.

Article  PubMed  PubMed Central  Google Scholar 

Guo W, Liu X, Li J, et al. Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury. Int J Biol Macromol. 2018;112:608–15.

Article  CAS  PubMed  Google Scholar 

Hotamisligil GS, Davis RJ. Cell signaling and stress responses. Cold Spring Harb Perspect Biol. 2016;8(10):a006072.

Article  PubMed  PubMed Central  Google Scholar 

Jin J, Ma Y, Tong X, et al. Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK. Hum Reprod. 2020;35(8):1947–8.

Article  PubMed  PubMed Central  Google Scholar 

Lumley EC, Osborn AR, Scott JE, et al. Moderate endoplasmic reticulum stress activates a PERK and p38-dependent apoptosis. Cell Stress Chaperones. 2017;22(1):43–54.

Article  CAS  PubMed  Google Scholar 

Govindarajan S, Gaublomme D, Van der Cruyssen R, et al. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha. Nat Commun. 2018;9(1):5340.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim HS, Kim Y, Lim MJ, et al. The p38-activated ER stress-ATF6α axis mediates cellular senescence. FASEB J. 2019;33(2):2422–34.

Article  CAS  PubMed  Google Scholar 

Zhang H, Rosenberg S, Coffey FJ, et al. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009;182(1):207–15.

Article  CAS  PubMed  Google Scholar