Gall H, Felix J, Schneck F, et al. The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups. J Heart Lung Transplant. 2017;36(9):957–67. https://doi.org/10.1016/j.healun.2017.02.016

Article  PubMed  Google Scholar 

Luna-López R, Ruiz Martín A, Escribano SP. Pulmonary arterial hypertension. Med Clin. 2022;158(12):622–9. https://doi.org/10.1016/j.medcli.2022.01.003

Article  Google Scholar 

Kim D, George M. Pulmonary hypertension. Med Clin North Am. 2019;103(3):413–23. https://doi.org/10.1016/j.mcna.2018.12.002

Article  PubMed  Google Scholar 

Smith K, Ayon R, Tang H, Makino A, Yuan J. Calcium-sensing receptor regulates cytosolic [ca] and plays a major role in the development of pulmonary hypertension. Front Physiol. 2016;7:517. https://doi.org/10.3389/fphys.2016.00517

Article  PubMed  PubMed Central  Google Scholar 

Zhou M, Cheng L, Chen L, Gu Y, Wang Y. Calcium-sensing receptor in the development and treatment of pulmonary hypertension. Mol Biol Rep. 2021;48(1):975–81. https://doi.org/10.1007/s11033-020-06065-3

Article  CAS  PubMed  Google Scholar 

Jain P, Zhao T, Xiong M, et al. Halofuginone, a promising drug for treatment of pulmonary hypertension. Br J Pharmacol. 2021;178(17):3373–94. https://doi.org/10.1111/bph.15442

Article  CAS  PubMed  Google Scholar 

Jain P, Lai N, Xiong M, et al. TRPC6, a therapeutic target for pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2021;321(6):L1161–82. https://doi.org/10.1152/ajplung.00159.2021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin M, Leung G, Zhang W, et al. Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca2+ channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension. Circ Res. 2004;95(5):496–505. https://doi.org/10.1161/01.RES.0000138952.16382.ad

Article  CAS  PubMed  Google Scholar 

Corbett E, Michalak M. Calcium, a signaling molecule in the endoplasmic reticulum? Trends Biochem Sci. 2000;25(7):307–11. https://doi.org/10.1016/s0968-0004(00)01588-7

Article  CAS  PubMed  Google Scholar 

Periasamy M, Reed T, Liu L, et al. Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem. 1999;274(4):2556–62. https://doi.org/10.1074/jbc.274.4.2556

Article  CAS  PubMed  Google Scholar 

Ye B, Zhou H, Chen Y, et al. USP25 ameliorates pathological cardiac hypertrophy by stabilizing SERCA2a in cardiomyocytes. Circ Res. 2023;132(4):465–80. https://doi.org/10.1161/circresaha.122.321849

Article  CAS  PubMed  Google Scholar 

Han S, Bal N, Sadi G, et al. Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction. Vascul Pharmacol. 2019;113:38–46. https://doi.org/10.1016/j.vph.2018.11.004

Article  CAS  PubMed  Google Scholar 

Liu B, Wang D, Luo E, et al. Role of TG2-mediated SERCA2 serotonylation on hypoxic pulmonary vein remodeling. Front Pharmacol. 2019;10:1611. https://doi.org/10.3389/fphar.2019.01611

Article  CAS  PubMed  Google Scholar 

Yu W, Zhang Q, Qiu Y, et al. CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells. Clin Exp Hypert (New York, NY : 1993). 2023;45(1):2272062. https://doi.org/10.1080/10641963.2023.2272062.

Article  CAS  Google Scholar 

Wu H, Wang T, Liu Y, et al. Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis. J Exp Clin Cancer Res: CR. 2020;39(1):274. https://doi.org/10.1186/s13046-020-01768-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu W, Jiang D, Gong F, et al. miR-210-5p promotes epithelial-mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells. Cell Death Dis. 2020;11(2):93. https://doi.org/10.1038/s41419-020-2270-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh N, Heggermont W, Fieuws S, et al. Endothelium-enriched microRNAs as diagnostic biomarkers for cardiac allograft vasculopathy. J Heart Lung Transplant. 2015;34(11):1376–84. https://doi.org/10.1016/j.healun.2015.06.008

Article  PubMed  Google Scholar 

Kho C, Lee A, Jeong D, et al. SUMO1-dependent modulation of SERCA2a in heart failure. Nature. 2011;477(7366):601–5. https://doi.org/10.1038/nature10407

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang A, Vita J. Effects of systemic inflammation on endothelium-dependent vasodilation. Trends Cardiovasc Med. 2006;16(1):15–20. https://doi.org/10.1016/j.tcm.2005.10.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

White K, Lu Y, Annis S, et al. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015;7(6):695–713. https://doi.org/10.15252/emmm.201404511

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cicchillitti L, Di Stefano V, Isaia E, et al. Hypoxia-inducible factor 1-α induces miR-210 in normoxic differentiating myoblasts. J Biol Chem. 2012;287(53):44761–71. https://doi.org/10.1074/jbc.M112.421255

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mutharasan RK, Nagpal V, Ichikawa Y, Ardehali H. microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects. Am J Physiol Heart Circ Physiol. 2011;301(4):H1519–30. https://doi.org/10.1152/ajpheart.01080.2010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kulshreshtha R, Ferracin M, Wojcik SE, et al. A microRNA signature of hypoxia. Mol Cell Biol. 2007;27(5):1859–67. https://doi.org/10.1128/mcb.01395-06

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brini M, Carafoli E. Calcium pumps in health and disease. Physiol Rev. 2009;89(4):1341–78. https://doi.org/10.1152/physrev.00032.2008

Article  CAS  PubMed  Google Scholar 

Dillmann W. Diabetic Cardiomyopathy. Circ Res. 2019;124(8):1160–2. https://doi.org/10.1161/circresaha.118.314665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadri L, Kratlian R, Benard L, et al. Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Circulation. 2013;128(5):512–23. https://doi.org/10.1161/circulationaha.113.001585.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark J, Kinnear N, Kalujnaia S, et al. Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle. J Biol Chem. 2010;285(18):13542–9. https://doi.org/10.1074/jbc.M110.101485

Article  CAS  PubMed  PubMed Central  Google Scholar