Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5

Pavlenko E, Ruengeler T, Engel P, Poepsel S. Functions and interactions of mammalian KDM5 demethylases. Front Genet. 2022;11(13): 906662.

Article  Google Scholar 

Holowatyj A, Yang ZQ, Pile LA. Histone lysine demethylases in Drosophila melanogaster. Fly. 2015;9(1):36–44.

Article  PubMed  PubMed Central  Google Scholar 

Lee N, Zhang J, Klose RJ, Erdjument-Bromage H, Tempst P, Jones RS, et al. The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol. 2007;14(4):341–3.

Article  CAS  PubMed  Google Scholar 

Secombe J, Li L, Carlos L, Eisenman RN. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev. 2007;21(5):537–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, et al. The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 2007;128(5):889–900.

Article  CAS  PubMed  Google Scholar 

Klein BJ, Piao L, Xi Y, Rincon-Arano H, Rothbart SB, Peng D, et al. The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Cell Rep. 2014;6(2):325–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang GJ, Zhu MH, Lu XJ, Liu YJ, Lu JF, Leung CH, et al. The emerging role of KDM5A in human cancer. J Hematol Oncol. 2021;14(1):30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blair LP, Cao J, Zou MR, Sayegh J, Yan Q. Epigenetic regulation by lysine demethylase 5 (KDM5) enzymes in cancer. Cancers. 2011;3(1):1383–404.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatch HAM, Secombe J. Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes-Jensen syndrome. FEBS J. 2021. https://doi.org/10.1111/febs.16204.

Article  PubMed  PubMed Central  Google Scholar 

Yamamoto S, Wu Z, Russnes HG, Takagi S, Peluffo G, Vaske C, et al. JARID1B is a luminal lineage-driving oncogene in breast cancer. Cancer Cell. 2014;25(6):762–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, et al. KDM5 histone demethylase activity links cellular transcriptomic heterogeneity to therapeutic resistance. Cancer Cell. 2018;34(6):939-953.e9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, et al. Characterization of a linked jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases. J Biol Chem. 2016;291(6):2631–46.

Article  CAS  PubMed  Google Scholar 

Arifuzzaman S, Khatun MR, Khatun R. Emerging of lysine demethylases (KDMs): From pathophysiological insights to novel therapeutic opportunities. Biomed Pharmacother. 2020;129: 110392.

Article  CAS  PubMed  Google Scholar 

He R, Xhabija B, Gopi LK, Kurup JT, Xu Z, Liu Z, et al. H3K4 demethylase KDM5B regulates cancer cell identity and epigenetic plasticity. Oncogene. 2022;41(21):2958–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xhabija B, Kidder BL. KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer. Semin Cancer Biol. 2019;57:79–85.

Article  CAS  PubMed  Google Scholar 

Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, et al. Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell. 2013;23(6):811–25.

Article  CAS  PubMed  Google Scholar 

Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007;128(6):1077–88.

Article  CAS  PubMed  Google Scholar 

Abidi FE, Holloway L, Moore CA, Weaver DD, Simensen RJ, Stevenson RE, et al. Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. J Med Genet. 2008;45(12):787–93.

Article  CAS  PubMed  Google Scholar 

Tzschach A, Lenzner S, Moser B, Reinhardt R, Chelly J, Fryns JP, et al. Novel JARID1C/SMCX mutations in patients with X-linked mental retardation. Hum Mutat. 2006;27(4):389.

Article  PubMed  Google Scholar 

El Hayek L, Tuncay IO, Nijem N, Russell J, Ludwig S, Kaur K, et al. KDM5A mutations identified in autism spectrum disorder using forward genetics. Elife. 2020;22(9): e56883.

Article  Google Scholar 

Harrington J, Wheway G, Willaime-Morawek S, Gibson J, Walters ZS. Pathogenic KDM5B variants in the context of developmental disorders. Biochim Biophys Acta Gene Regul Mech. 2022;1865(5): 194848.

Article  CAS  PubMed  Google Scholar 

Iwase S, Brookes E, Agarwal S, Badeaux AI, Ito H, Vallianatos CN, et al. A mouse model of X-linked intellectual disability associated with impaired removal of histone methylation. Cell Rep. 2016;14(5):1000–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scandaglia M, Lopez-Atalaya JP, Medrano-Fernandez A, Lopez-Cascales MT, Del Blanco B, Lipinski M, et al. Loss of Kdm5c causes spurious transcription and prevents the fine-tuning of activity-regulated enhancers in neurons. Cell Rep. 2017;21(1):47–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belalcazar HM, Hendricks EL, Zamurrad S, Liebl FLW, Secombe J. The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction. Cell Rep. 2021;34(7): 108753.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatch HA, Belalcazar HM, Marshall OJ, Secombe J. A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation. Elife. 2021. https://doi.org/10.7554/eLife.63886.

Article  PubMed  PubMed Central  Google Scholar 

Zamurrad S, Hatch HAM, Drelon C, Belalcazar HM, Secombe J. A drosophila model of intellectual disability caused by mutations in the histone demethylase KDM5. Cell Rep. 2018;22(9):2359–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao W, Peng Y, Lin D. The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity. Biochem Biophys Res Commun. 2010;396(2):323–8.

Article  CAS  PubMed  Google Scholar 

Tu S, Teng YC, Yuan C, Wu YT, Chan MY, Cheng AN, et al. The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif. Nat Struct Mol Biol. 2008;15(4):419–21.

Article  CAS  PubMed  Google Scholar 

Scibetta AG, Santangelo S, Coleman J, Hall D, Chaplin T, Copier J, et al. Functional analysis of the transcription repressor PLU-1/JARID1B. Mol Cell Biol. 2007;27(20):7220–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Villaseñor R, Pfaendler R, Ambrosi C, Butz S, Giuliani S, Bryan E, et al. ChromID identifies the protein interactome at chromatin marks. Nat Biotechnol. 2020;38(6):728–36.

Article  PubMed  PubMed Central  Google Scholar 

Li L, Greer C, Eisenman RN, Secombe J. Essential functions of the histone demethylase lid. PLoS Genet. 2010;6(11): e1001221.

Article  PubMed  PubMed Central  Google Scholar 

Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 2009;459(7248):847–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drelon C, Belalcazar HM, Secombe J. The histone demethylase KDM5 is essential for larval growth in drosophila. Genetics. 2018;209(3):773–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brookes E, Laurent B, Õunap K, Carroll R, Moeschler JB, Field M, et al. Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity. Hum Mol Genet. 2015;24(10):2861–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vallianatos CN, Farrehi C, Friez MJ, Burmeister M, Keegan CE, Iwase S. Altered gene-regulatory function of KDM5C by a novel mutation associated with aut

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