Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular rnas are a large class of animal rnas with regulatory potency. Nature. 2013;495(7441):333–8.

Article  CAS  Google Scholar 

Sanger HL, Klotz G, Riesner D, Gross HJ, Kleinschmidt AK. Viroids are single-stranded covalently closed circular rna molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976;73(11):3852–6.

Article  CAS  Google Scholar 

Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of rna in the cytoplasm of eukaryotic cells. Nature. 1979;280(5720):339–40.

Article  CAS  Google Scholar 

Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, et al. Circular transcripts of the testis-determining gene sry in adult mouse testis. Cell. 1993;73(5):1019–30.

Article  CAS  Google Scholar 

Cocquerelle C, Mascrez B, Hétuin D, Bailleul B. Mis-splicing yields circular rna molecules. FASEB J. 1993;7(1):155–60.

Article  CAS  Google Scholar 

Chen X, Han P, Zhou T, Guo X, Song X, Li Y. Circrnadb: a comprehensive database for human circular rnas with protein-coding annotations. Sci Rep. 2016;6:34985.

Article  CAS  Google Scholar 

Abdelmohsen K, Panda A, Munk R, Grammatikakis I, Dudekula D, De S, et al. Identification of hur target circular rnas uncovers suppression of pabpn1 translation by circpabpn1. RNA Biol. 2017;14(3):361–9.

Article  Google Scholar 

Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, et al. Circrna biogenesis competes with pre-mrna splicing. Mol Cell. 2014;56(1):55–66.

Article  CAS  Google Scholar 

Ying C, Guohai Y, Ye Z, et al. High glucose-induced circhipk3 downregulation mediates endothelial cell injury. Biochem Biophys Res Commun. 2018;507(1–4):362–8.

Google Scholar 

Lu D, Thum T. Rna-based diagnostic and therapeutic strategies for cardiovascular disease. Nat Rev Cardiol. 2019;16(11):661–74.

Article  Google Scholar 

Zhang TR, Huang WQ. Angiogenic circular rnas: a new landscape in cardiovascular diseases. Microvasc Res. 2020;129:103983.

Article  CAS  Google Scholar 

Chen I, Chen CY, Chuang TJ. Biogenesis, identification, and function of exonic circular rnas. Wiley Interdiscip Rev RNA. 2015;6(5):563–79.

Article  CAS  Google Scholar 

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, et al. Exon-intron circular rnas regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22(3):256–64.

Article  Google Scholar 

Kelly SGC, Cook PR, Papantonis A. Exon skipping is correlated with exon circularization. J Mol Biol. 2015;427(15):2414–7.

Article  CAS  Google Scholar 

Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, et al. Circular intronic long noncoding rnas. Mol Cell. 2013;51(6):792–806.

Article  CAS  Google Scholar 

Vo J, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, et al. The landscape of circular rna in cancer. Cell. 2019;176(4):869-81.e13.

Article  CAS  Google Scholar 

Suzuki H, Tsukahara T. A view of pre-mrna splicing from rnase r resistant rnas. Int J Mol Sci. 2014;15(6):9331–42.

Article  CAS  Google Scholar 

Du W, Yang W, Chen Y, Wu Z, Foster F, Yang Z, et al. Foxo3 circular rna promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J. 2017;38(18):1402–12.

CAS  Google Scholar 

Cai J, Chen Z, Wang J, Wang J, Chen X, Liang L, et al. Circhectd1 facilitates glutaminolysis to promote gastric cancer progression by targeting mir-1256 and activating β-catenin/c-myc signaling. Cell Death Dis. 2019;10(8):576.

Article  Google Scholar 

Qu S, Liu Z, Yang X, Zhou J, Yu H, Zhang R, et al. The emerging functions and roles of circular rnas in cancer. Cancer Lett. 2018;414:301–9.

Article  CAS  Google Scholar 

Wen G, Zhou T, Gu W. The potential of using blood circular rna as liquid biopsy biomarker for human diseases. Protein Cell. 2020.

Huang A, Zheng H, Wu Z, Chen M, Huang Y. Circular rna-protein interactions: functions, mechanisms, and identification. Theranostics. 2020;10(8):3503–17.

Article  CAS  Google Scholar 

Hansen T, Wiklund E, Bramsen J, Villadsen S, Statham A, Clark S, et al. Mirna-dependent gene silencing involving ago2-mediated cleavage of a circular antisense rna. EMBO J. 2011;30(21):4414–22.

Article  CAS  Google Scholar 

Park O, Ha H, Lee Y, Boo S, Kwon D, Song H, et al. Endoribonucleolytic cleavage of ma-containing rnas by rnase p/mrp complex. Mol Cell. 2019;74(3):494-507.e8.

Article  CAS  Google Scholar 

Fischer J, Busa V, Shao Y, Leung A. Structure-mediated rna decay by upf1 and g3bp1. Mol Cell. 2020;78(1):70-84.e6.

Article  CAS  Google Scholar 

Jia R, Xiao M, Li Z, Shan G, Huang C. Defining an evolutionarily conserved role of gw182 in circular rna degradation. Cell Discov. 2019;5:45.

Article  Google Scholar 

Liu C, Li X, Nan F, Jiang S, Gao X, Guo S, et al. Structure and degradation of circular rnas regulate pkr activation in innate immunity. Cell. 2019;177(4):865-80.e21.

Article  CAS  Google Scholar 

Liang D, Tatomer DC, Luo Z, Wu H, Yang L, Chen L-L, et al. The output of protein-coding genes shifts to circular rnas when the pre-mrna processing machinery is limiting. Mol Cell. 2017;68(5):940-54.e3.

Article  CAS  Google Scholar 

Beermann J, Piccoli M, Viereck J, Thum T. Non-coding rnas in development and disease: background, mechanisms, and therapeutic approaches. Physiol Rev. 2016;96(4):1297–325.

Article  CAS  Google Scholar 

Ebert MS, Neilson JR, Sharp PA. Microrna sponges: competitive inhibitors of small rnas in mammalian cells. Nat Methods. 2007;4(9):721–6.

Article  CAS  Google Scholar 

Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mrnas regulates tumour biology. Nature. 2010;465(7301):1033–8.

Article  CAS  Google Scholar 

Zhao F, Chen T, Jiang N. Cdr1as/mir-7/ckap4 axis contributes to the pathogenesis of abdominal aortic aneurysm by regulating the proliferation and apoptosis of primary vascular smooth muscle cells. Exp Ther Med. 2020;19(6):3760–6.

CAS  Google Scholar 

Piwecka M, Glazar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, et al. Loss of a mammalian circular rna locus causes mirna deregulation and affects brain function. Science. 2017;357(6357):eaam8526.

Article  Google Scholar 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, et al. Natural rna circles function as efficient microrna sponges. Nature. 2013;495(7441):384–8.

Article  CAS  Google Scholar 

Quan H, Chen Q, Wang K, Wang Q, Lu M, Zhang Y, et al. Exendin-4 reversed the pc12 cell damage induced by circrna cdr1as/mir-671/gsk3β signaling pathway. J Mol Neurosci. 2020;71(4):778–89.

Article  Google Scholar 

Dang R, Liu F, Li Y. Circular rna hsa_circ_0010729 regulates vascular endothelial cell proliferation and apoptosis by targeting the mir-186/hif-1α axis. Biochem Biophys Res Commun. 2017;490(2):104–10.

Article  CAS  Google Scholar 

Zhuang J, Li T, Hu X, Ning M, Gao W, Lang Y, et al. Circ_chfr expedites cell growth, migration and inflammation in ox-ldl-treated human vascular smooth muscle cells via the mir-214-3p/wnt3/β-catenin pathway. Eur Rev Med Pharmacol Sci. 2020;24(6):3282–92.

Google Scholar 

Bressin A, Schulte-Sasse R, Figini D, Urdaneta EC, Beckmann BM, Marsico A. Tripepsvm: de novo prediction of rna-binding proteins based on short amino acid motifs. Nucleic Acids Res. 2019;47(9):4406–17.

Article  CAS  Google Scholar 

Zang J, Lu D, Xu A. The interaction of circrnas and rna binding proteins: an important part of circrna maintenance and function. J Neurosci Res. 2020;98(1):87–97.

Article  CAS  Google Scholar 

Ma S, Kong S, Wang F, Ju S. Circrnas: biogenesis, functions, and role in drug-resistant tumours. Mol Cancer. 2020;19(1):119.

Article  CAS  Google Scholar 

Zeng Y, Du W, Wu Y, Yang Z, Awan F, Li X, et al. A circular rna binds to and activates akt phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair. Theranostics. 2017;7(16):3842–55.

Article  CAS  Google Scholar 

Conn S, Pillman K, Toubia J, Conn V, Salmanidis M, Phillips C, et al. The rna binding protein quaking regulates formation of circrnas. Cell. 2015;160(6):1125–34.

Article  CAS  Google Scholar 

Holdt L, Stahringer A, Sass K, Pichler G, Kulak N, Wilfert W, et al. Circular non-coding rna anril modulates ribosomal rna maturation and atherosclerosis in humans. Nat Commun. 2016;7:12429.

Article  CAS  Google Scholar 

Abe N, Matsumoto K, Nishihara M, Nakano Y, Shibata A, Maruyama H, et al. Rolling circle translation of circular rna in living human cells. Sci Rep. 2015;5:16435.

Article  CAS  Google Scholar 

Santer L, Bär C, Thum T. Circular rnas: a novel class of functional rna molecules with a therapeutic perspective. Mol Ther. 2019;27(8):1350–63.

Article  CAS  Google Scholar 

Lei M, Zheng G, Ning Q, Zheng J, Dong D. Translation and functional roles of circular rnas in human cancer. Mol Cancer. 2020;19(1):30.

Article  CAS  Google Scholar 

Pamudurti N, Bartok O, Jens M, Ashwal-Fluss R, Stot