Center for Behavioral Health Statistics and Quality. 2020 National survey on drug use and health: detailed tables. Rockville: Substance Abuse and Mental Health Services Administration; 2020.

Google Scholar 

DiFranza J, Savageau J, Rigotti N, Fletcher K, Ockene J, McNeill A, et al. Development of symptoms of tobacco dependence in youths: 30 month follow up data from the DANDY study. Tob Control. 2002;11(3):228–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thorner ED, Jaszyna-Gasior M, Epstein DH, Moolchan ET. Progression to daily smoking: is there a gender difference among cessation treatment seekers? Subst Use Misuse. 2007;42(5):829–35.

Article  PubMed  Google Scholar 

National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The health consequences of smoking—50 years of progress: a report of the surgeon general (Reports of the Surgeon General). Atlanta: Centers for Disease Control and Prevention (US); 2014.

Google Scholar 

Perkins KA, Scott J. Sex differences in long-term smoking cessation rates due to nicotine patch. Nicotine Tob Res. 2008;10(7):1245–51.

Article  CAS  PubMed  Google Scholar 

Smith PH, Bessette AJ, Weinberger AH, Sheffer CE, McKee SA. Sex/gender differences in smoking cessation: a review. Prev Med. 2016;92:135–40.

Article  PubMed  PubMed Central  Google Scholar 

Markou A. Neurobiology of nicotine dependence. Philos Trans R Soc Lond B Biol Sci. 2008;363(1507):3159–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Willing J, Wagner CK. Progesterone receptor expression in the developing mesocortical dopamine pathway: importance for complex cognitive behavior in adulthood. Neuroendocrinology. 2016;103(3–4):207–22.

Article  CAS  PubMed  Google Scholar 

Vashchinkina E, Manner AK, Vekovischeva O, den Hollander B, Uusi-Oukari M, Aitta-aho T, et al. Neurosteroid agonist at GABA a receptor induces persistent neuroplasticity in VTA dopamine neurons. Neuropsychopharmacology. 2014;39(3):727–37.

Article  CAS  PubMed  Google Scholar 

Bali A, Jaggi AS. Multifunctional aspects of allopregnanolone in stress and related disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2014;48:64–78.

Article  CAS  PubMed  Google Scholar 

Anker JJ, Carroll ME. The role of progestins in the behavioral effects of cocaine and other drugs of abuse: human and animal research. Neurosci Biobehav Rev. 2010;35(2):315–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lynch WJ, Sofuoglu M. Role of progesterone in nicotine addiction: evidence from initiation to relapse. Exp Clin Psychopharmacol. 2010;18(6):451–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frye CA, Rhodes ME. Infusions of 3α,5α-THP to the VTA enhance exploratory, anti-anxiety, social, and sexual behavior and increase levels of 3α,5α-THP in midbrain, hippocampus, diencephalon, and cortex of female rats. Behav Brain Res. 2008;187(1):88–99.

Article  CAS  PubMed  Google Scholar 

Fish EW, Whitman BJ, DiBerto JF, Robinson JE, Morrow AL, Malanga CJ. Effects of the neuroactive steroid allopregnanolone on intracranial self-stimulation in C57BL/6J mice. Psychopharmacology. 2014;231(17):3415–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peart DR, Andrade AK, Logan CN, Knackstedt LA, Murray JE. Regulation of cocaine-related behaviours by estrogen and progesterone. Neurosci Biobehav Rev. 2022;135:104584.

Article  CAS  PubMed  Google Scholar 

Schüle C, Nothdurfter C, Rupprecht R. The role of allopregnanolone in depression and anxiety. Prog Neurobiol. 2014;113:79–87.

Article  PubMed  Google Scholar 

Milivojevic V, Fox HC, Sofuoglu M, Covault J, Sinha R. Effects of progesterone stimulated allopregnanolone on craving and stress response in cocaine dependent men and women. Psychoneuroendocrinology. 2016;65:44–53.

Article  CAS  PubMed  Google Scholar 

Parks EE, Logan S, Yeganeh A, Farley JA, Owen DB, Sonntag WE. Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. J Lipid Res. 2020;61(10):1308–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Picciotto MR, Caldarone BJ, King SL, Zachariou V. Nicotinic receptors in the brain: links between molecular biology and behavior. Neuropsychopharmacology. 2000;22(5):451–65.

Article  CAS  PubMed  Google Scholar 

Schwarzer C, Berresheim U, Pirker S, Wieselthaler A, Fuchs K, Sieghart W, et al. Distribution of the major ?-aminobutyric acid A receptor subunits in the basal ganglia and associated limbic brain areas of the adult rat. J Comp Neurol. 2001;433(4):526–49.

Article  CAS  PubMed  Google Scholar 

Sharp BM, Jiang Q, Simeone X, Scholze P. Allosteric modulation of GABAA receptors in rat basolateral amygdala blocks stress-enhanced reacquisition of nicotine self-administration. ACS Pharmacol Transl Sci. 2020;3(6):1158–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paradiso K, Sabey K, Evers AS, Zorumski CF, Covey DF, Steinbach JH. Steroid Inhibition of rat neuronal nicotinic α4β2 receptors expressed in HEK 293 cells. Mol Pharmacol. 2000;58(2):341–51.

Article  CAS  PubMed  Google Scholar 

Bullock AE, Clark AL, Grady SR, Robinson SF, Slobe BS, Marks MJ, et al. Neurosteroids modulate nicotinic receptor function in mouse striatal and thalamic synaptosomes. J Neurochem. 2002;68(6):2412–23.

Article  Google Scholar 

Allen SS, Bade T, Center B, Finstad D, Hatsukami D. Menstrual phase effects on smoking relapse. Addiction. 2008;103(5):809–21.

Article  PubMed  PubMed Central  Google Scholar 

Mazure CM, Toll B, McKee SA, Wu R, O’Malley SS. Menstrual cycle phase at quit date and smoking abstinence at six weeks in an open label trial of bupropion. Drug Alcohol Depend. 2011;114(1):68–72.

Article  PubMed  Google Scholar 

Franklin TR, Jagannathan K, Ketcherside A, Spilka N, Wetherill RR. Menstrual cycle phase modulates responses to smoking cues in the putamen: preliminary evidence for a novel target. Drug Alcohol Depend. 2019;198:100–4.

Article  PubMed  PubMed Central  Google Scholar 

Allen A, Tosun N, Carlson S, Allen S. Postpartum changes in mood and smoking-related symptomatology: an ecological momentary assessment investigation. Nicotine Tob Res. 2018;20(6):681–9.

Article  PubMed  Google Scholar 

Forray A, Gilstad-Hayden K, Suppies C, Bogen D, Sofuoglu M, Yonkers KA. Progesterone for smoking relapse prevention following delivery: a pilot, randomized, double-blind study. Psychoneuroendocrinology. 2017;86:96–103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sofuoglu M, Babb DA, Hatsukami DK. Progesterone treatment during the early follicular phase of the menstrual cycle: effects on smoking behavior in women. Pharmacol Biochem Behav. 2001;69(1–2):299–304.

Article  CAS  PubMed  Google Scholar 

Sofuoglu M, Mouratidis M, Mooney M. Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers. Psychoneuroendocrinology. 2011;36(1):123–32.

Article  CAS  PubMed  Google Scholar 

Allen A, Petersen A, Harrison K, Nair U, Allen S. Effect of exogenous progesterone administration on smoking topography. Addict Behav. 2021;112:106570.

Article  PubMed  Google Scholar 

Sofuoglu M, Mitchell E, Mooney M. Progesterone effects on subjective and physiological responses to intravenous nicotine in male and female smokers. Hum Psychopharmacol Clin Exp. 2009;24(7):559–64.

Article  CAS  Google Scholar 

Tosun NL, Fieberg AM, Eberly LE, Harrison KA, Tipp AR, Allen AM, et al. Exogenous progesterone for smoking cessation in men and women: a pilot double-blind, placebo-controlled randomized clinical trial. Addiction. 2019;114(10):1800–13.

Article  PubMed  PubMed Central  Google Scholar 

Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, et al. Progesterone increases nicotine withdrawal and anxiety in male but not female smokers during brief abstinence. Nicotine Tob Res. 2022. https://doi.org/10.1093/ntr/ntac146.

Article  PubMed  Google Scholar 

Anker JJ, Holtz NA, Zlebnik N, Carroll ME. Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats. Psychopharmacology. 2009;203(1):63–72.

Article  CAS  PubMed  Google Scholar 

Anker JJ, Carroll ME. Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats. Drug Alcohol Depend. 2010;107(2):264–7.

Article  CAS  PubMed  Google Scholar 

Evans SM, Foltin RW. Exogenous progesterone attenuates the subjective effects of smoked cocaine in women, but not in men. Neuropsychopharmacology. 2006;31(3):659–74.

Article  CAS