Morata, G. & Ripoll, P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. https://doi.org/10.1016/0012-1606(75)90330-9 (1975).
Moreno, E., Basler, K. & Morata, G. Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 416, 755–759 (2002).
Schultz, J. The minute reaction in the development of Drosophila melanogaster. Genetics 14, 366–419 (1929).
CAS PubMed PubMed Central Google Scholar
Moreno, E. & Basler, K. dMyc transforms cells into super-competitors. Cell https://doi.org/10.1016/S0092-8674(04)00262-4 (2004).
de la Cova, C. et al. Drosophila Myc regulates organ size by inducing cell competition. Cell 117, 107–116 (2004).
Kim, W. & Jain, R. Picking winners and losers: cell competition in tissue development and homeostasis. Trends Genet. 36, 490–498 (2020).
CAS PubMed PubMed Central Google Scholar
Baker, N. E. Emerging mechanisms of cell competition. Nat. Rev. Genet. 21, 683–697 (2020).
CAS PubMed PubMed Central Google Scholar
Parker, T. M. et al. Cell competition in intratumoral and tumor microenvironment interactions. EMBO J. https://doi.org/10.15252/embj.2020107271 (2021).
Article PubMed PubMed Central Google Scholar
Vishwakarma, M. & Piddini, E. Outcompeting cancer. Nat. Rev. Cancer 20, 187–198 (2020).
Simons, B. D. & Clevers, H. Strategies for homeostatic stem cell self-renewal in adult tissues. Cell 145, 851–862 (2011).
Vermeulen, L. & Snippert, H. J. Stem cell dynamics in homeostasis and cancer of the intestine. Nat. Rev. Cancer 14, 468–480 (2014).
Klein, A. M. & Simons, B. D. Universal patterns of stem cell fate in cycling adult tissues. Development 138, 3103–3111 (2011).
Clavería, C., Giovinazzo, G., Sierra, R. & Torres, M. Myc-driven endogenous cell competition in the early mammalian embryo. Nature 500, 39–44 (2013). This work provides the first evidence for mammalian supercompetition and demonstrates how stochastic heterogeneity in gene expression can result in temporal fitness differences that drive active elimination.
Martincorena, I. et al. Universal patterns of selection in cancer and somatic tissues. Cell 171, 1029–1041.e21 (2017).
CAS PubMed PubMed Central Google Scholar
Wennekamp, S., Mesecke, S., Nédélec, F. & Hiiragi, T. A self-organization framework for symmetry breaking in the mammalian embryo. Nat. Rev. Mol. Cell Biol. 14, 454–461 (2013).
Kimura, M. The Neutral Theory of Molecular Evolution (Cambridge University Press, 1983).
Ozbudak, E. M., Thattai, M., Kurtser, I., Grossman, A. D. & Van Oudenaarden, A. Regulation of noise in the expression of a single gene. Nat. Genet. 31, 69–73 (2002).
Elowitz, M. B., Levine, A. J., Siggia, E. D. & Swain, P. S. Stochastic gene expression in a single cell. Science 297, 1183–1186 (2002).
De Navascués, J. et al. Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells. EMBO J. 31, 2473–2485 (2012).
PubMed PubMed Central Google Scholar
Amoyel, M., Simons, B. D. & Bach, E. A. Neutral competition of stem cells is skewed by proliferative changes downstream of Hh and Hpo. EMBO J. 33, 2295–2313 (2014).
CAS PubMed PubMed Central Google Scholar
Lopez-Garcia, C., Klein, A. M., Simons, B. D. & Winton, D. J. Intestinal stem cell replacement follows a pattern of neutral drift. Science 330, 822–825 (2010).
Snippert, H. J. et al. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell 143, 134–144 (2010).
Doupé, D. P. et al. A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science 337, 1091–1093 (2012).
PubMed PubMed Central Google Scholar
Clayton, E. et al. A single type of progenitor cell maintains normal epidermis. Nature 446, 185–189 (2007).
Scheele, C. L. G. J. et al. Identity and dynamics of mammary stem cells during branching morphogenesis. Nature 542, 313–317 (2017).
CAS PubMed PubMed Central Google Scholar
Bailey, N. T. J. The elements of stochastic processes with applications to the natural sciences (Wiley, 1966).
Williams, M. J., Werner, B., Barnes, C. P., Graham, T. A. & Sottoriva, A. Identification of neutral tumor evolution across cancer types. Nat. Genet. 48, 238–244 (2016).
CAS PubMed PubMed Central Google Scholar
Ritsma, L. et al. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature 507, 362–365 (2014).
CAS PubMed PubMed Central Google Scholar
Vermeulen, L. et al. Defining stem cell dynamics in models of intestinal tumor initiation. Science 342, 995–998 (2013).
Snippert, H. J., Schepers, A. G., Van Es, J. H., Simons, B. D. & Clevers, H. Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. EMBO Rep. 15, 62–69 (2014).
Krotenberg Garcia, A. et al. Active elimination of intestinal cells drives oncogenic growth in organoids. Cell Rep. 36, 109307 (2021).
CAS PubMed PubMed Central Google Scholar
Eichenlaub, T., Cohen, S. M. & Herranz, H. Cell competition drives the formation of metastatic tumors in a drosophila model of epithelial tumor formation. Curr. Biol. 26, 419–427 (2016).
Ohsawa, S. et al. Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev. Cell 20, 315–328 (2011).
Li, W. & Baker, N. E. Engulfment is required for cell competition. Cell 129, 1215–1225 (2007).
Ellis, S. J. et al. Distinct modes of cell competition shape mammalian tissue morphogenesis. Nature https://doi.org/10.1038/s41586-019-1199-y (2019). This work provides some of the first evidence that the mode of competition within a tissue can change on the basis of an organisms life stage.
Article PubMed PubMed Central Google Scholar
Jin, Z. et al. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell https://doi.org/10.1016/j.stem.2007.10.021 (2008).
Article PubMed PubMed Central Google Scholar
van Neerven, S. M. et al. Apc-mutant cells act as supercompetitors in intestinal tumour initiation. Nature 594, 436–441 (2021).
Flanagan, D. J. et al. NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 594, 430–435 (2021).
Sun, Q. et al. Competition between human cells by entosis. Cell Res. 24, 1299–1310 (2014).
CAS PubMed PubMed Central Google Scholar
Hamann, J. C. et al. Entosis is induced by glucose starvation. Cell Rep. 20, 201–210 (2017).
CAS PubMed PubMed Central Google Scholar
Ayukawa, S. et al. Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction. Nat. Immunol. 22, 1391–1402 (2021).
Wagstaff, L. et al. Mechanical cell competition kills cells via induction of lethal p53 levels. Nat. Commun. 7, 11373 (2016).
CAS PubMed PubMed Central Google Scholar
Hill, W. et al. EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas. Curr. Biol. 31, 2550–2560.e5 (2021).
CAS PubMed PubMed Central Google Scholar
Porazinski, S. et al. EphA2 drives the segregation of Ras-transformed epithelial cells from normal neighbors. Curr. Biol. 26, 3220–3229 (2016).
Shraiman, B. I. Mechanical feedback as a possible regulator of tissue growth. Proc. Natl Acad. Sci. USA 102, 3318–3323 (2005).
CAS PubMed PubMed Central Google Scholar
Eisenhoffer, G. T. et al. Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature 484, 546–549 (2012).
留言 (0)