Karki, R., and T.D. Kanneganti. 2021. The ‘cytokine storm’: Molecular mechanisms and therapeutic prospects. Trends in Immunology 42 (8): 681–705.

CAS  Article  Google Scholar 

Kumar, V. 2020. Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets. IntImmunopharmacol 89 (Pt B): 107087.

CAS  Article  Google Scholar 

Fajgenbaum, D.C., and C.H. June. 2020. Cytokine storm. New England Journal of Medicine 383 (23): 2255–2273.

CAS  Article  Google Scholar 

Janssen, N.A.F., I. Grondman, A.H. de Nooijer, C.K. Boahen, V.A.C.M. Koeken, V. Matzaraki, V. Kumar, X. He, M. Kox, H.J.P.M. Koenen, R.L. Smeets, I. Joosten, R.J.M. Brüggemann, I.J.E. Kouijzer, H.G. van der Hoeven, J.A. Schouten, T. Frenzel, M.H.E. Reijers, W. Hoefsloot, A.S.M. Dofferhoff, M.J. van Apeldoorn, M.J.T. Blaauw, K. Veerman, C. Maas, A.H. Schoneveld, I.E. Hoefer, L.P.G. Derde, M. van Deuren, J.W.M. van der Meer, R. van Crevel, E.J. Giamarellos-Bourboulis, L.A.B. Joosten, M.M. van den Heuvel, J. Hoogerwerf, Q. de Mast, P. Pickkers, M.G. Netea, and F.L. van de Veerdonk. 2021. Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19. Journal of Infectious Diseases 223 (8): 1322–1333.

CAS  Article  Google Scholar 

Yongzhi, X. 2021. COVID-19-associated cytokine storm syndrome and diagnostic principles: An old and new Issue. Emerg Microbes Infect 10 (1): 266–276.

Article  Google Scholar 

Kim J.S., J.Y Lee, J.W Yang, K.H Lee, M Effenberger, W Szpirt, A and Kronbichler J.I Shin. 2021. Immunopathogenesis and treatment of cytokine storm in COVID-19. Theranostics 11(1): 316–329.

Copaescu, A., O. Smibert, A. Gibson, E.J. Phillips, and J.A. Trubiano. 2020. The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection. The Journal of Allergy and Clinical Immunology 146 (3): 518-534.e1.

CAS  Article  Google Scholar 

Su, L., L. Feng, Q. Song, H. Kang, X. Zhang, Z. Liang, Y. Jia, D. Feng, C. Liu, and L. Xie. 2013. Diagnostic value of dynamics serum sCD163, sTREM-1, PCT, and CRP in differentiating sepsis, severity assessment, and prognostic prediction. Mediators of Inflammation 2013: 969875.

PubMed  PubMed Central  Google Scholar 

Yang, A.P., J. Liu, L.H. Yue, H.Q. Wang, W.J. Yang, and G.H. Yang. 2016. Neutrophil CD64 combined with PCT, CRP and WBC improves the sensitivity for the early diagnosis of neonatal sepsis. Clinical Chemistry and Laboratory Medicine 54 (2): 345–351.

CAS  Article  Google Scholar 

Horiuchi, T., H. Mitoma, S. Harashima, H. Tsukamoto, and T. Shimoda. 2010. Transmembrane TNF-alpha: Structure, function and interaction with anti-TNF agents. Rheumatology (Oxford) 49 (7): 1215–1228.

CAS  Article  Google Scholar 

Ware, C.F., P.D. Crowe, M.H. Grayson, M.J. Androlewicz, and J.L. Browning. 1992. Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells. The Journal of Immunology 149 (12): 3881–3888.

CAS  PubMed  Google Scholar 

Wright, H.L., B. Chikura, R.C. Bucknall, R.J. Moots, and S.W. Edwards. 2011. Changes in expression of membrane TNF, NF-B activation and neutrophil apoptosis during active and resolved inflammation. Annals of the Rheumatic Diseases 70 (3): 537–543.

CAS  Article  Google Scholar 

Ardestani, S., B. Li, D.L. Deskins, H. Wu, P.P. Massion, and P.P. Young. 2013. Membrane versus soluble isoforms of TNF-α exert opposing effects on tumor growth and survival of tumor-associated myeloid cells. Cancer Research 73 (13): 3938–3950.

CAS  Article  Google Scholar 

Yu, M., X. Zhou, L. Niu, G. Lin, J. Huang, W. Zhou, H. Gan, J. Wang, X. Jiang, B. Yin, and Z. Li. 2013. Targeting transmembrane TNF-α suppresses breast cancer growth. Cancer Research 73 (13): 4061–4074.

CAS  Article  Google Scholar 

Yokota, S., T. Miyamae, Y. Kuroiwa, and K. Nishioka. 2021. Novel coronavirus disease 2019 (COVID-19) and cytokine storms for more effective treatments from an inflammatory pathophysiology. Journal of Clinical Medicine 10 (4): 801.

CAS  Article  Google Scholar 

Yang, R., X. Zou, J. Tenhunen, and T.I. Tønnessen. 2017. HMGB1 and extracellular histones significantly contribute to systemic inflammation and multiple organ failure in acute liver failure. Mediators of Inflammation 2017: 5928078.

PubMed  PubMed Central  Google Scholar 

Greenfield, K.G., V.P. Badovinac, T.S. Griffith, and K.A. Knoop. 2021. Sepsis, cytokine storms, and immunopathology: The divide between neonates and adults. Immunohorizons 5 (6): 512–522.

CAS  Article  Google Scholar 

Yuan, S., S.C. Jiang, Z.W. Zhang, Y.F. Fu, J. Hu, and Z.L. Li. 2021. Quantification of cytokine storms during virus infections. Frontiers in Immunology 12: 659419.

CAS  Article  Google Scholar 

Morris G., C.C., Bortolasci, B.K Puri, W Marx, A O'Neil, E Athan, K Walder, M Berk, L Olive, A.F Carvalho and M Maes. 2021. The cytokine storms of COVID-19, H1N1 influenza, CRS and MAS compared. Can one sized treatment fit all? Cytokine 144:155593.

Bernardi, M., R. Moreau, P. Angeli, B. Schnabl and V. Arroyo. 2015. Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis. Journal of Hepatology 63 (5): 1272–1284.

Clària J., R. EStauber, M.J Coenraad, R. Moreau, R. Jalan, M. Pavesi, À. Amorós, E. Titos, J. Alcaraz-Quiles, K. Oettl, M. Morales-Ruiz, P. Angeli, M. Domenicali, C. Alessandria, A. Gerbes, J. Wendon, F. Nevens, J.T. Rebicka, W. Laleman, F. Saliba, T.M. Welzel, A. Albillos, T. Gustot, D. Benten, F. Durand, P. Ginès, M. Bernardi and V. Arroyo. 2016. CANONIC Study Investigators of the EASL-CLIF Consortium and the European Foundation for the Study of Chronic Liver Failure (EF-CLIF). Systemic inflammation in decompensated cirrhosis: characterization and role in acute-on-chronic liver failure. Hepatology 64(4): 1249–64.

Durand, F., I. Graupera, P. Ginès, J. COlson and M. K. Nadim. 2016. Pathogenesis of hepatorenal syndrome: Implications for therapy. American Journal of Kidney Diseases 67 (2): 318–328.

Shakil, A.O., and DKramer, G.V. Mazariegos, J.J. Fung and J. Rakela. 2000. Acute liver failure: Clinical features, outcome analysis, and applicability of prognostic criteria. Liver Transplantation 6 (2): 163–169.

NorelliM., B Camisa, G Barbiera, L Falcone, A Purevdorj, M Genua, F Sanvito, M Ponzoni, C Doglioni, P Cristofori, C Traversari, C Bordignon, F Ciceri, R Ostuni, C Bonini, M Casucci, and A Bondanza. 2018. Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells. Nature Medicine 24 (6): 739–748.

Article  Google Scholar 

Han, H., Q. Ma, C. Li, R. Liu, L. Zhao, W. Wang, P. Zhang, X. Liu, G. Gao, F. Liu, Y. Jiang, X. Cheng, C. Zhu, and Y. Xia. 2020. Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. Emerg Microbes Infect 9 (1): 1123–1130.

CAS  Article  Google Scholar 

Broman, N., K. Rantasärkkä, T. Feuth, M. Valtonen, M. Waris, U. Hohenthal, E. Rintala, A. Karlsson, H. Marttila, V. Peltola, T. Vuorinen, and J. Oksi. 2021. IL-6 and other biomarkers as predictors of severity in COVID-19. Annals of Medicine 53 (1): 410–412.

CAS  Article  Google Scholar 

Karki, R., B.R. Sharma, S. Tuladhar, E.P. Williams, L. Zalduondo, P. Samir, M. Zheng, B. Sundaram, B. Banoth, R.K.S. Malireddi, P. Schreiner, G. Neale, P. Vogel, R. Webby, C.B. Jonsson, and T.D. Kanneganti. 2021. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. Cell 184 (1): 149-168.e17.

CAS  Article  Google Scholar 

Michels, M., Q. de Mast, M.G. Netea, L.A. Joosten, C.A. Dinarello, P.I. Rudiman, S. Sinarta, R. Wisaksana, B. Alisjahbana, and A.J. van der Ven. 2015. Normal free interleukin-18 (IL-18) plasma levels in dengue virus infection and the need to measure both total IL-18 and IL-18 binding protein levels. Clinical and Vaccine Immunology 22 (6): 650–655.

CAS  Article  Google Scholar 

Mandrekar, J.N. 2010. Receiver operating characteristic curve in diagnostic test assessment. J ThoracOncol 5 (9): 1315–1316.

Google Scholar 

Obuchowski N.A and J.A Bullen. 2018. Receiver operating characteristic (ROC) curves: review of methods with applications in diagnostic medicine. Physics in Medicine & Biology 63(7): 07TR01.

Liu, F., L. Li, M. Xu, J. Wu, D. Luo, Y. Zhu, B. Li, X. Song, and X. Zhou. 2020. Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19. J ClinVirol 127: 104370.

CAS  Google Scholar 

Mahmood, Alam J., S.S. Asghar, H. Ali, S.R. Mahmood, and M.A. Ansari. 2021. REPORT- Varying pattern of blood gases, ferritin, procalcitonin, C-reactive protein, interleukin 6 and lactate dehydrogenase in Covid-19 patients suffering from diverse co-morbid, suspected cytokine storm and periodic effects of antiviral and steroidal treatments. Pakistan Journal of Pharmaceutical Sciences 34 (6): 2265–2271.

PubMed  Google Scholar 

Potempa, L.A., I.M. Rajab, P.C. Hart, J. Bordon, and R. Fernandez-Botran. 2020. Insights into the use of C-reactive protein as a diagnostic index of disease severity in COVID-19 infections. American Journal of Tropical Medicine and Hygiene 103 (2): 561–563.

CAS  Article  Google Scholar 

Luo, W., J.W. Zhang, W. Zhang, Y.L. Lin, and Q. Wang. 2021. Circulating levels of IL-2, IL-4, TNF-α, IFN-γ, and C-reactive protein are not associated with severity of COVID-19 symptoms. Journal of Medical Virology 93 (1): 89–91.

CAS  Article  Google Scholar