Succinic Acid Ameliorates Concanavalin A-Induced Hepatitis by Altering the Inflammatory Microenvironment and Expression of BCL-2 Family Proteins

Goel, A., and P. Kwo. 2024. Treatment of autoimmune hepatitis. Clinics in Liver Disease 28 (1): 51–61.

Article  PubMed  Google Scholar 

Beretta-Piccoli, B.T., G. Mieli-Vergani, and D. Vergani. 2022. Autoimmmune hepatitis. Cellular & Molecular Immunology 19 (2): 158–176.

Article  Google Scholar 

Pabst, O., M.W. Hornef, F.G. Schaap, V. Cerovic, T. Clavel, and T. Bruns. 2023. Gut-liver axis: Barriers and functional circuits. Nature Reviews Gastroenterology & Hepatology 20 (7): 447–461.

Article  Google Scholar 

Tilg, H., T.E. Adolph, and M. Trauner. 2022. Gut-liver axis: Pathophysiological concepts and clinical implications. Cell Metabolism 34 (11): 1700–1718.

Article  CAS  PubMed  Google Scholar 

Sass, G., S. Heinlein, A. Agli, R. Bang, J. Schümann, and G. Tiegs. 2002. Cytokine expression in three mouse models of experimental hepatitis. Cytokine 19 (3): 115–120.

Article  CAS  PubMed  Google Scholar 

Khan, H.A., M.Z. Ahmad, J.A. Khan, and M.I. Arshad. 2017. Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance. Hepatobiliary & Pancreatic Diseases International 16 (3): 245–256.

Article  CAS  Google Scholar 

Fujita, T., K. Soontrapa, Y. Ito, K. Iwaisako, C.S. Moniaga, M. Asagiri, et al. 2016. Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis. Hepatology 63 (4): 1325–1339.

Article  CAS  PubMed  Google Scholar 

Wei, Y.-h, X. Ma, J.-C. Zhao, X.-Q. Wang, and C.-Q. Gao. 2023. Succinate metabolism and its regulation of host-microbe interactions. Gut Microbes. 15 (1).

Yuan, Y., Y. Xu, J. Xu, B. Liang, X. Cai, C. Zhu, et al. 2017. Succinate promotes skeletal muscle protein synthesis via Erk1/2 signaling pathway. Molecular Medicine Reports. 16 (5): 7361–7366.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, K., M. Liao, N. Zhou, L. Bao, K. Ma, Z. Zheng, et al. 2019. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Reports 26 (1): 222.

Article  PubMed  Google Scholar 

Moyon, A., P. Garrigue, L. Balasse, S. Fernandez, P. Brige, A. Bouhlel, et al. 2021. Succinate injection rescues vasculature and improves functional recovery following acute peripheral ischemia in rodents: A multimodal imaging study. Cells 10 (4).

Cao, Z., S. Mu, M. Wang, Y. Zhang, G. Zou, X. Yuan, et al. 2023. Succinate pretreatment attenuates intestinal ischemia-reperfusion injury by inhibiting necroptosis and inflammation via upregulating Klf4. International Immunopharmacology 120.

Nadjsombati, M.S., J.W. McGinty, M.R. Lyons-Cohen, J.B. Jaffe, L. DiPeso, C. Schneider, et al. 2018. Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit. Immunity 49 (1): 33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schneider, C., C.E. O’Leary, J. von Moltke, H.-E. Liang, Q.Y. Ang, P.J. Turnbaugh, et al. 2018. A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling. Cell 174 (2): 271.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Macias-Ceja, D.C., D. Ortiz-Masia, P. Salvador, L. Gisbert-Ferrandiz, C. Hernandez, M. Hausmann, et al. 2019. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunology 12 (1): 178–187.

Article  CAS  PubMed  Google Scholar 

Rubic, T., G. Lametschwandtner, S. Jost, S. Hinteregger, J. Kund, N. Carballido-Perrig, et al. 2008. Triggering the succinate receptor GPR91 on dendritic cells enhances immunity. Nature Immunology 9 (11): 1261–1269.

Article  CAS  PubMed  Google Scholar 

Erhardt, A., and G. Tiegs. 2010. Tolerance induction in response to liver inflammation. Digestive Diseases 28 (1): 86–92.

Article  PubMed  Google Scholar 

Gatselis, N.K., K. Zachou, G.K. Koukoulis, and G.N. Dalekos. 2015. Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics. World Journal of Gastroenterology 21 (1): 60–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sebode, M., J. Hartl, D. Vergani, A.W. Lohse, Int Autoimmune hepatitis Grp I. 2018. Autoimmune hepatitis: From current knowledge and clinical practice to future research agenda. Liver International 38 (1): 15–22.

Article  PubMed  Google Scholar 

Wang, H.-X., M. Liu, S.-Y. Weng, J.-J. Li, C. Xie, H.-L. He, et al. 2012. Immune mechanisms of Concanavalin A model of autoimmune hepatitis. World Journal of Gastroenterology 18 (2): 119–125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neumann, K., K. Karimi, J. Meiners, R. Voetlause, S. Steinmann, W. Dammermann, et al. 2017. A proinflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis. Journal of Immunology 198 (1): 128–137.

Article  CAS  Google Scholar 

Ives, S.J., K.S. Zaleski, C. Slocum, D. Escudero, C. Sheridan, S. Legesse, et al. 2020. The effect of succinic acid on the metabolic profile in high-fat diet-induced obesity and insulin resistance. Physiological Reports 8 (21): e14630-Article No.: e.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hakak, Y., K. Lehmann-Bruinsma, S. Phillips, T. Le, C. Liaw, D.T. Connolly, et al. 2009. The role of the GPR91 ligand succinate in hematopoiesis. Journal of Leukocyte Biology 85 (5): 837–843.

Article  CAS  PubMed  Google Scholar 

Liu, H., H. Zhang, X. Zhang, Q. Chen, and L. Xia. 2022. Role of succinic acid in the regulation of sepsis. International Immunopharmacology 110.

Iplik, E.S., T. Catmakas, and B. Cakmakoglu. 2018. A new target for the treatment of endometrium cancer by succinic acid. Cellular and Molecular Biology 64 (1): 60–63.

Article  PubMed  Google Scholar 

Chen, H., C. Jin, L. Xie, and J. Wu. 2024. Succinate as a signaling molecule in the mediation of liver diseases. Biochimica Et Biophysica Acta-Molecular Basis of Disease 1870 (2).

Li, Y.H., S.H. Woo, D.H. Choi, and E.-H. Cho. 2015. Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells. Biochemical and Biophysical Research Communications 463 (4): 853–858.

Article  CAS  PubMed  Google Scholar 

Correa, P.R.A.V., E.A. Kruglov, M. Thompson, M.F. Leite, J.A. Dranoff, and M.H. Nathanson. 2007. Succinate is a paracrine signal for liver damage. Journal of Hepatology 47 (2): 262–269.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatano, M., S. Sasaki, S. Ohata, Y. Shiratsuchi, T. Yamazaki, K. Nagata, et al. 2008. Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis. Cellular Immunology 251 (1): 25–30.

Article  CAS  PubMed  Google Scholar 

Schümann, J., D. Wolf, A. Pahl, K. Brune, T. Papadopoulos, N. van Rooijen, et al. 2000. Importance of Kupffer cells for T-cell-dependent liver injury in mice. American Journal of Pathology 157 (5): 1671–1683.

Article  PubMed  PubMed Central  Google Scholar 

Dong, Z., H. Wei, R. Sun, and Z. Tian. 2007. The roles of innate immune cells in liver injury and regeneration. Cellular & Molecular Immunology 4 (4): 241–252.

CAS  Google Scholar 

Trauelsen, M., T.K. Hiron, D. Lin, J.E. Petersen, B. Breton, A.S. Husted, et al. 2021. Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling. Cell Reports 35 (11): 1.

Article  Google Scholar 

Jakubowski, A., M. Sternak, K. Jablonski, M. Ciszek-Lenda, J. Marcinkiewicz, and S. Chlopicki. 2016. 1-Methylnicotinamide protects against liver injury induced by concanavalin A via a prostacyclin-dependent mechanism: A possible involvement of IL-4 and TNF-α. International Immunopharmacology 31: 98–104.

Article  CAS  PubMed  Google Scholar 

Mizuhara, H., M. Uno, N. Seki, M. Yamashita, M. Yamaoka, T. Ogawa, et al. 1996. Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis. Hepatology 23 (6): 1608–1615.

CAS  PubMed  Google Scholar 

Ksontini, R., D.B. Colagiovanni, M.D. Josephs, C.K. Edwards, C.L. Tannahill, C.C. Solorzano, et al. 1998. Disparate roles for TNF-α and Fas ligand in concanavalin A-induced hepatitis. Journal of Immunology 160 (8): 4082–4089.

Article  CAS  Google Scholar 

Llambi, F., and D.R. Green. 2011. Apoptosis and oncogenesis: Give and take in the BCL-2 family. Current Opinion in Genetics & Development 21 (1): 12–20.

Article  CAS  Google Scholar 

Edlich, F. 2018. BCL-2 proteins and apoptosis: Recent insights and unknowns. Biochemical and Biophysical Research Communications 500 (1): 26–34.

Article  CAS  PubMed  Google Scholar 

Chen, H.C., M. Kanai, A. Inoue-Yamauchi, H.C. Tu, Y.F. Huang, D.C. Ren, et al. 2015. An interconnected hierarchical model of cell death regulation by the BCL-2 family. Nature Cell Biology 17 (10): 1270.

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif