Aili Y, Maimaitiming N, Mahemuti Y, Qin H, Wang Y, Wang Z (2021) The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application.Frontiers in Oncology,3385

Al-Nedawi K (2008) Intercellular transfer of the oncogenic EGFRv III via tumor cell derived microvesicles. Nat Cell Biol 10:619–624

CAS  PubMed  Article  Google Scholar 

Al-Nedawi K, Lhotak Meehanbmicallefj, May V, Rak J (2008) Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 10:619–624

CAS  PubMed  Article  Google Scholar 

Allahdini F, Reza-Zarei Amirjamshidia, Abdollahi M (2010) Evaluating the prognostic factors effective on the outcome of patients with glioblastoma multiformis: does maximal resection of the tumor lengthen the median survival?World Neurosurg, 73, 128 – 34; discussion e16.

Arscott Wt, Zhao Tandleat, Gordon Sshabasonje, Schlaff Ik, Zhang Cd, Tofilon G, Camphausen Ka (2013) Ionizing radiation and glioblastoma exosomes: implications in tumor biology and cell migration. Translational Oncol 6:638–IN6

Article  Google Scholar 

Balaj L, Dai Lessardr, Cho L, Pomeroy Y-J, Skog J (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun 2:1–9

Article  CAS  Google Scholar 

BĂLAȘA A, ȘErban G, Chinezu R, HurghiȘ C, TĂMAȘ F, Manu D (2020) The Involvement of Exosomes in Glioblastoma Development, Diagnosis, Prognosis, and Treatment. Brain sciences, 10, 553

Batista Bs, Eng Ws, Hendricks-MuÑOz Pilobellokt, Mahal Lk (2011) Identification of a conserved glycan signature for microvesicles. J Proteome Res 10:4624–4633

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen Ww, Balaj L, Liau Lm, Samuels Ml, Maguire Kotsopoulossk, Soto Caloguidicel, Garrett H, Zhu Ld (2013) BEAMing and droplet digital PCR analysis of mutant IDH1 mRNA in glioma patient serum and cerebrospinal fluid extracellular vesicles. Mol Therapy-Nucleic Acids 2:e109

Article  CAS  Google Scholar 

Chistiakov Da, Chekhonin Vp (2014) Extracellular vesicles shed by glioma cells: pathogenic role and clinical value. Tumor Biology 35:8425–8438

CAS  PubMed  Article  Google Scholar 

Chuang H-Y, Su Y-K, Chen Liuh-W, Cho C-Hchius-C, Chen D-Ylins-Z, Lin C-M (2019) Preclinical evidence of STAT3 inhibitor pacritinib overcoming temozolomide resistance via downregulating miR-21-enriched exosomes from M2 glioblastoma-associated macrophages. J Clin Med 8:959

CAS  PubMed Central  Article  Google Scholar 

D’Asti E, Huang A, Kool M, Meehan B, Jabado Chanja, Rak J (2016) Tissue factor regulation by miR-520 g in primitive neuronal brain tumor cells: a possible link between oncomirs and the vascular tumor microenvironment. Am J Pathol 186:446–459

PubMed  PubMed Central  Article  CAS  Google Scholar 

D’Souza-Schorey C, Clancy Jw (2012) Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers. Genes Dev 26:1287–1299

PubMed  PubMed Central  Article  CAS  Google Scholar 

D’Asti E, Huang A, Rak J (2012) Downregulation of tissue factor (TF) in medulloblastoma cells expressing miR-520 g. Proceedings of Keystone Syposia

Dai J, Su Y, Zhong S, Cong L, Liu B, Tao Yangj, He Y, Chen Z, Jiang Y (2020) Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Ther 5:145

CAS  PubMed  PubMed Central  Article  Google Scholar 

De Vrij J, Maas Sn, Kwappenberg Km, Dekker Schnoorrkleijna, Luider L, De Tm, Witte Ld, Litjens M (2015) & VAN STRIEN, M. E. Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells. International journal of cancer, 137, 1630–1642

Esmaeili M, Hosseini Niazivpourfathollahaa, Nakhlestani Mkm, Taheri Mgolzadehk, Ghafouri-Fard M, Atarodi K (2019) The impact of parathyroid hormone treated mesenchymal stem cells on ex-vivo expansion of cord blood hematopoietic stem cells. Gene Rep 17:100490

Article  Google Scholar 

Felsberg J, Rapp M, Fimmers Loesers, Stummer R, Goeppert W, Friedensdorf Msteigerhj, Reifenberger B, Sabel Mc (2009) Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients. Clin Cancer Res 15:6683–6693

CAS  PubMed  Article  Google Scholar 

Gallego O (2015) Nonsurgical treatment of recurrent glioblastoma. Curr Oncol 22:e273–e281

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ghafouri-Fard S, Abak Agabalazadeha, Shoorei A, Hassanzadeh Taheri H, Taheri Mm, Sharifi G 2021a. Role of Long Non-Coding RNAs in Conferring Resistance in Tumors of the Nervous System.Front Oncol, 11,670917

Ghafouri-Fard S, Abak Glassymc, Hussen A, Niazi Bm, Taheri M (2021b) The interaction between miRNAs/lncRNAs and Notch pathway in human disorders. Biomed Pharmacother 138:111496

CAS  PubMed  Article  Google Scholar 

Ghafouri-Fard S, Niazi V, Taheri M (2020a) Role of miRNAs and lncRNAs in hematopoietic stem cell differentiation. Non-coding RNA Research

Ghafouri-Fard S, Niazi V, Taheri M (2020b) Role of miRNAs in conveying message of stem cells via extracellular vesicles.Experimental and Molecular Pathology,104569

Giusti I, Delle Monache S, Di Francesco M, SanitÀ P, D’Ascenzo S, Dolo V (2016) From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis. Tumor Biology 37:12743–12753

CAS  PubMed  Article  Google Scholar 

Graner Mw, Dechkovskaia Alzateo, Bigner Dd (2009) Proteomic and immunologic analyses of brain tumor exosomes. FASEB J 23:1541–1557

CAS  PubMed  PubMed Central  Article  Google Scholar 

Guescini M, Stocchi Genedanis, Agnati Lf (2010) Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J Neural Transm 117:1–4

CAS  PubMed  Article  Google Scholar 

Hellwinkel Je, Harland Redzicjs, Gunaydin Ta, Anchordoquy D, Graner Mw (2015) Glioma-derived extracellular vesicles selectively suppress immune responses. Neurooncology 18:497–506

Google Scholar 

Kalluri R, Lebleu Vs (2020) The biology, function, and biomedical applications of exosomes.Science,367

Kucharzewska P, Svensson Christiansonhcwelchje, RingnÉR Kjfredlunde, MÖRgelin M, Bourseau-Guilmain M, Belting M (2013) Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proceedings of the National Academy of Sciences, 110, 7312–7317

Lan F, Pan Qingq, Yu Qhum, Yue X (2018) Serum exosomal miR-301a as a potential diagnostic and prognostic biomarker for human glioma. Cell Oncol (Dordr) 41:25–33

CAS  Article  Google Scholar 

Litak J, Mazurek M, Kamieniak Grochowskic, RoliŃSki J (2019) PD-L1/PD-1 Axis in Glioblastoma Multiforme. Int J Mol Sci 20:5347

CAS  PubMed Central  Article  Google Scholar 

Liu Y, Shete S, Hosking F, Robertson L, Houlston R, Bondy M (2010) Genetic advances in glioma: susceptibility genes and networks. Curr Opin Genet Dev 20:239–244

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mallawaaratchy Dm, Hallal S, Ly Russellb, Ebrahimkhani L, Wei S, Kaufman Kl (2017) Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. J Neurooncol 131:233–244

CAS  PubMed  Article  Google Scholar 

Naryzhny S, Kopylov Volnitskiya, Zorina A, Kamyshinsky E, Bairamukov R, Shtam T (2020) Proteome of Glioblastoma-Derived Exosomes as a Source of Biomarkers. Biomedicines, 8, 216

Niazi V, Ahani Parsehb, Karami M, Gilanchi F, Atarodi S, Soufi K, Ghafouri-Fard Msoleimanim, Taheri M (2020) Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche. Biomed Pharmacother 132:110854

CAS  PubMed  Article  Google Scholar 

Pinet S, Bessette B, Vedrenne N, Battu Lacroixarichardljauberteaum-O, LallouÉ F (2016) TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells. Oncotarget 7:50349

PubMed  PubMed Central  Article  Google Scholar 

Putz U, Goh Howittjdoana, Silke C-Plowl-H, Tan S-S (2012) The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. Sci Signal 5:ra70–ra70

PubMed  Article  CAS  Google Scholar 

Qian M, Guo Wangs, Zhang Xwangj, Gao Zqiuw, Chen X, Xu Z, Zhao R (2020) Hypoxic glioma-derived exosomes deliver microRNA-1246 to induce M2 macrophage polarization by targeting TERF2IP via the STAT3 and NF-κB pathways. Oncogene 39:428–442

CAS  PubMed  Article  Google Scholar 

Rezaei O, Taheri Tamizkarkhsharifig, Ghafouri-Fard S (2020) Emerging Role of Long Non-Coding RNAs in the Pathobiology of Glioblastoma. Front Oncol 10:625884

PubMed  Article  Google Scholar 

Ricklefs F, Mineo M, Nakano Roojak, Charest I, Breakefield Aweisslederr, Godlewski Xochioccaea, Bronisz A (2016) Extracellular vesicles from high-grade glioma exchange diverse pro-oncogenic signals that maintain intratumoral heterogeneity. Cancer Res 76:2876–2881

CAS  PubMed  PubMed Central  Article  Google Scholar 

Roth P, Weller M (2014) Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment strategies. Neurooncology 16:viii14–viii19

Google Scholar 

Sathornsumetee S, Rich Jn (2006) New approaches to primary brain tumor treatment. Anticancer Drugs 17:1003–1016

CAS  PubMed  Article  Google Scholar 

Setti M, Osti D, Ortensi Richichic, Del B, Bene M, Beznoussenko Fornasaril, Mironov G, Rappa A, Cuomo A (2015) Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth. Oncotarget 6:31413

PubMed  PubMed Central  Article  Google Scholar 

Seystahl K, Tritschler I, Szabo E, Tabatabai G, Weller M (2015) Differential regulation of TGF-β–induced, ALK-5–mediated VEGF release by SMAD2/3 versus SMAD1/5/8 signaling in glioblastoma. Neurooncology 17:254–265

CAS  Google Scholar 

Shao H, Lee Chungj, Balaj K, Min L, Carter C, Hochberg Bs, Lee Fhbreakefieldxo, Weissleder R (2015) Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma. Nat Commun 6:1–9

Google Scholar 

Skog J, Wurdinger T, Van Rijn S, Meijer D, Sena-Esteves Gainchel, Curry W Jr, Carter Bs, Krichevsky Am, Breakefield Xo (2008a) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.Nat Cell Biol, 10,1470–1476

CAS  PubMed  PubMed Central  Article  Google Scholar 

Skog J, WÜRdinger T, Van Rijn S, Meijer Dh, Curry Gainchel, Krichevsky Wtcarterbs, A. M. & Breakefield, X. O (2008b) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470–1476

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sun X, Zhao Maxwangj, Wang Y, Chen Ybihljc, Jiang C (2017) Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal. Oncotarget 8:36137