Stewart EA. Clinical practice. Uterine fibroids. N Engl J Med. 2015;372:1646–55.
CAS PubMed Article Google Scholar
Cardozo ER, Clark AD, Banks NK, Henne MB, Stegmann BJ, Segars JH. The estimated annual cost of uterine leiomyomata in the United States. Am J Obstet Gynecol. 2012;206:211.e211–9.
Ip PPC, Bennett JA, Croce S, Garg K, Yang B. Uterine leiomyoma. In: Rabban JT, Nucci MR, Malpica A, Brenton JD, Hui P, Ordi J et al., editors. WHO classification of tumors: female genital tumours. 5th edn. Lyon, France: IARC Publications; 2020. pp 272–6.
Mehine M, Mäkinen N, Heinonen HR, Aaltonen LA, Vahteristo P. Genomics of uterine leiomyomas: insights from high-throughput sequencing. Fertil Steril. 2014;102:621–9.
CAS PubMed Article Google Scholar
Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30:406–10.
CAS PubMed Article Google Scholar
Berta DG, Kuisma H, Välimäki N, Räisänen M, Jäntti M, Pasanen A, et al. Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma. Nature. 2021;596:398–403.
CAS PubMed Article Google Scholar
Mäkinen N, Kämpjärvi K, Frizzell N, Bützow R, Vahteristo P. Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors. Mol Cancer. 2017;16:101.
PubMed PubMed Central Article CAS Google Scholar
Hodge JC, Pearce KE, Clayton AC, Taran FA, Stewart EA. Uterine cellular leiomyomata with chromosome 1p deletions represent a distinct entity. Am J Obstet Gynecol. 2014;210:572 e571–77.
Mehine M, Kaasinen E, Heinonen HR, Makinen N, Kampjarvi K, Sarvilinna N, et al. Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers. Proc Natl Acad Sci USA. 2016;113:1315–20.
CAS PubMed PubMed Central Article Google Scholar
Podkalicka P, Mucha O, Kruczek S, Biela A, Andrysiak K, Stępniewski J, et al. Synthetically lethal interactions of heme oxygenase-1 and fumarate hydratase genes. Biomolecules. 2020;10:143.
CAS PubMed Central Article Google Scholar
Song MY, Lee DY, Chun KS, Kim EH. The role of NRF2/KEAP1 signaling pathway in cancer metabolism. Int J Mol Sci. 2021;22:4376.
CAS PubMed PubMed Central Article Google Scholar
Ooi A, Wong JC, Petillo D, Roossien D, Perrier-Trudova V, Whitten D, et al. An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell. 2011;20:511–23.
CAS PubMed Article Google Scholar
Pohl C, Dikic I. Cellular quality control by the ubiquitin-proteasome system and autophagy. Science. 2019;366:818–22.
CAS PubMed Article Google Scholar
Rojo de la Vega M, Chapman E, Zhang DD. NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018;34:21–43.
CAS PubMed Article Google Scholar
Kerins MJ, Ooi A. A catalogue of somatic NRF2 gain-of-function mutations in cancer. Sci Rep. 2018;8:12846.
PubMed PubMed Central Article CAS Google Scholar
Mehine M, Khamaiseh S, Ahvenainen T, Heikkinen T, Ayravainen A, Pakarinen P, et al. 3′RNA sequencing accurately classifies formalin-fixed paraffin-embedded uterine leiomyomas. Cancers (Basel). 2020;12:3839.
CAS PubMed Central Article Google Scholar
Ahvenainen T, Kaukomaa J, Kämpjärvi K, Uimari O, Ahtikoski A, Mäkinen N, et al. Comparison of 2SC, AKR1B10, and FH antibodies as potential biomarkers for FH-deficient uterine leiomyomas. Am J Surg Pathol. 2022;46:537–46.
Mäkinen N, Vahteristo P, Kämpjärvi K, Arola J, Bützow R, Aaltonen LA. MED12 exon 2 mutations in histopathological uterine leiomyoma variants. Eur J Hum Genet. 2013;21:1300–03.
PubMed PubMed Central Article CAS Google Scholar
Ahvenainen TV, Mäkinen NM, von Nandelstadh P, Vahteristo MEA, Pasanen AM, Bützow RC, et al. Loss of ATRX/DAXX expression and alternative lengthening of telomeres in uterine leiomyomas. Cancer. 2018;124:4650–56.
CAS PubMed Article Google Scholar
Äyräväinen A, Pasanen A, Ahvenainen T, Heikkinen T, Pakarinen P, Härkki P, et al. Systematic molecular and clinical analysis of uterine leiomyomas from fertile-aged women undergoing myomectomy. Hum Reprod. 2020;35:2237–44.
PubMed Article CAS Google Scholar
Kopanos C, Tsiolkas V, Kouris A, Chapple CE, Albarca Aguilera M, Meyer R, et al. VarSome: the human genomic variant search engine. Bioinformatics. 2019;35:1978–80.
CAS PubMed Article Google Scholar
Rentzsch P, Witten D, Cooper GM, Shendure J, Kircher M. CADD: predicting the deleteriousness of variants throughout the human genome. Nucleic Acids Res. 2019;47:D886–94.
CAS PubMed Article Google Scholar
Cheng J, Guo J, Wang Z, North BJ, Tao K, Dai X, et al. Functional analysis of Cullin 3 E3 ligases in tumorigenesis. Biochim Biophys Acta Rev Cancer. 2018;1869:11–28.
CAS PubMed Article Google Scholar
Zhou W, Xu J, Tan M, Li H, Li H, Wei W, et al. UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F. Mol Cell. 2018;70:1008–1024. e1006.
CAS PubMed PubMed Central Article Google Scholar
Enchev RI, Schulman BA, Peter M. Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol. 2015;16:30–44.
CAS PubMed PubMed Central Article Google Scholar
Baek K, Scott DC, Schulman BA. NEDD8 and ubiquitin ligation by cullin-RING E3 ligases. Curr Opin Struct Biol. 2020;67:101–9.
PubMed PubMed Central Article CAS Google Scholar
Lo SC, Hannink M. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol. 2006;26:1235–44.
CAS PubMed PubMed Central Article Google Scholar
Wimuttisuk W, Singer JD. The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer. Mol Biol Cell. 2007;18:899–909.
CAS PubMed PubMed Central Article Google Scholar
Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009;458:732–6.
CAS PubMed Article Google Scholar
Andérica-Romero AC, Hernández-Damián J, Vázquez-Cervantes GI, Torres I, González-Herrera IG, Pedraza-Chaverri J. The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation. Redox Biol. 2016;8:341–7.
PubMed PubMed Central Article CAS Google Scholar
Zhou H, Lu J, Liu L, Bernard D, Yang CY, Fernandez-Salas E, et al. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nat Commun. 2017;8:1150.
PubMed PubMed Central Article CAS Google Scholar
Zhou H, Lu J, Chinnaswamy K, Stuckey JA, Liu L, McEachern D, et al. Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity. Nat Commun. 2021;12:2621.
CAS PubMed PubMed Central Article Google Scholar
Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, et al. Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). Oncogene. 2002;21:3003–10.
CAS PubMed Article Google Scholar
Dubiel W, Chaithongyot S, Dubiel D, Naumann M. The COP9 Signalosome: a multi-DUB complex. Biomolecules. 2020;10:1082.
CAS PubMed Central Article Google Scholar
Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T. Cleavage of the C-terminus of NEDD8 by UCH-L3. Biochem Biophys Res Commun. 1998;251:688–92.
CAS PubMed Article Google Scholar
Bishop P, Rocca D, Henley JM. Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction. Biochem J. 2016;473:2453–62.
CAS PubMed Article Google Scholar
Miettinen M, Felisiak-Golabek A, Wasag B, Chmara M, Wang Z, Butzow R, et al. Fumarase-deficient uterine leiomyomas: an immunohistochemical, molecular genetic, and clinicopathologic study of 86 cases. Am J Surg Pathol. 2016;40:1661–9.
PubMed PubMed Central Article Google Scholar
Sanz-Ortega J, Vocke C, Stratton P, Linehan WM, Merino MJ. Morphologic and molecular characteristics of uterine leiomyomas in hereditary leiomyomatosis and renal cancer (HLRCC) syndrome. Am J Surg Pathol. 2013;37:74–80.
留言 (0)