Aglah C, Gordon T, Posse de Chaves EI (2008) cAMP promotes neurite outgrowth and extension through protein kinase A but independently of Erk activation in cultured rat motoneurons. Neuropharmacology 55:8–17. https://doi.org/10.1016/j.neuropharm.2008.04.005

CAS  Article  PubMed  Google Scholar 

Amaya F, Samad TA, Barrett L, Broom DC, Woolf CJ (2009) Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion. Pain 142:59–67. https://doi.org/10.1016/j.pain.2008.11.013

CAS  Article  PubMed  PubMed Central  Google Scholar 

Arber S, Han B, Mendelsohn M, Smith M, Jessell TM, Sockanathan S (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23:659–674. https://doi.org/10.1016/S0896-6273(01)80026-X

CAS  Article  PubMed  Google Scholar 

Bento-Abreu A, Tabernero A, Medina JM (2007) Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons. J Neurochem 103:871–881. https://doi.org/10.1111/j.1471-4159.2007.04807.x

CAS  Article  PubMed  Google Scholar 

Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K (2011) A functionally characterized test set of human induced pluripotent stem cells. Nat Biotechnol 29:279–287. https://doi.org/10.1038/nbt.1783

CAS  Article  PubMed  PubMed Central  Google Scholar 

Chi L, Ke Y, Luo C, Li B, Gozal D, Kalyanaraman B, Liu R (2006) Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice. Stem Cells 24:34–43. https://doi.org/10.1634/stemcells.2005-0076

Article  PubMed  Google Scholar 

Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K (2014) How to make spinal motor neurons. Development 141:491–501. https://doi.org/10.1242/dev.097410

CAS  Article  PubMed  Google Scholar 

Ebrahimi-Barough S, Hoveizi E, Yazdankhah M, Ai J, Khakbiz M, Faghihi F, Tajerian R, Bayat N (2017) Inhibitor of PI3K/Akt signaling pathway small molecule promotes motor neuron differentiation of human endometrial stem cells cultured on electrospun biocomposite polycaprolactone/collagen scaffolds. Mol Neurobiol 54:2547–2554. https://doi.org/10.1007/s12035-016-9828-z

CAS  Article  PubMed  Google Scholar 

Falik Zaccai TC, Savitzki D, Zivony-Elboum Y, Vilboux T, Fitts EC, Shoval Y, Kalfon L, Samra N, Keren Z, Gross B, Chasnyk N, Straussberg R, Mullikin JC, Teer JK, Geiger D, Kornitzer D, Bitterman-Deutsch O, Samson AO, Wakamiya M, Peterson JW, Kirtley ML, Pinchuk IV, Baze WB, Gahl WA, Kleta R, Anikster Y, Chopra AK (2017) Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. Brain 140:370–386. https://doi.org/10.1093/brain/aww295

Article  PubMed  Google Scholar 

Forman BM, Chen J, Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci USA 94:4312–4317. https://doi.org/10.1073/pnas.94.9.4312

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gaudet RJ, Alam I, Levine L (1980) Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. J Neurochem 35:653–658. https://doi.org/10.1111/j.1471-4159.1980.tb03704.x

CAS  Article  PubMed  Google Scholar 

Goncalves MB, Williams EJ, Yip P, Yáñez-Muñoz RJ, Williams G, Doherty P (2010) The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain. Br J Pharmacol 159:1118–1125. https://doi.org/10.1111/j.1476-5381.2009.00618.x

CAS  Article  PubMed  PubMed Central  Google Scholar 

Grill M, Heinemann A, Hoefler G, Peskar BA, Schuligoi R (2008) Effect of endotoxin treatment on the expression and localization of spinal cyclooxygenase, prostaglandin synthases, and PGD2 receptors. J Neurochem 104:1345–1357. https://doi.org/10.1111/j.1471-4159.2007.05078.x

CAS  Article  PubMed  Google Scholar 

Guo W, Naujock M, Fumagalli L, Vandoorne T, Baatsen P, Boon R, Ordovás L, Patel A, Welters M, Vanwelden T, Geens N, Tricot T, Benoy V, Steyaert J, Lefebvre-Omar C, Boesmans W, Jarpe M, Sterneckert J, Wegner F, Petri S, Bohl D, Vanden Berghe P, Robberecht W, Van Damme P, Verfaillie C, Van Den Bosch L (2017) HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients. Nat Commun 8:861. https://doi.org/10.1038/s41467-017-00911-y

CAS  Article  PubMed  PubMed Central  Google Scholar 

Gurwitz D, Cunningham DD (1988) Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proc Natl Acad Sci U S A 85:3440–3444. https://doi.org/10.1073/pnas.85.10.3440

CAS  Article  PubMed  PubMed Central  Google Scholar 

Han SW, Greene ME, Pitts J, Wada RK, Sidell N (2001) Novel expression and function of peroxisome proliferator-activated receptor gamma (PPARϒ) in human neuroblastoma cells. Clin Cancer Res 7:98–104

CAS  PubMed  Google Scholar 

Hiruma H, Ichikawa T, Kobayashi H, Hoka S, Takenaka T, Kawakami T (2000) Prostaglandin E2 enhances axonal transport and neuritogenesis in cultured mouse dorsal root ganglion neurons. Neuroscience 100:885–891. https://doi.org/10.1016/S0306-4522(00)00347-X

CAS  Article  PubMed  Google Scholar 

Ho L, Luterman JD, Aisen PS, Pasinetti GM, Montine TJ, Morrow JD (2000) Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 55:323. https://doi.org/10.1212/WNL.55.2.323

CAS  Article  PubMed  Google Scholar 

Hounoum BM, Vourch P, Felix R, Corcia P, Patin F, Guéguinou M, Potier-Cartereau M, Vandier C, Raoul C, Andres CR, Mavel S, Blasco H (2016) NSC-34 motor neuron-like cells are unsuitable as experimental model for glutamate-mediated excitotoxicity. Front Cell Neurosci 10:1–9. https://doi.org/10.3389/fncel.2016.00118

CAS  Article  Google Scholar 

Hu BY, Zhang SC (2009) Differentiation of spinal motor neurons from pluripotent human stem cells. Nat Protoc 4:1295–1304. https://doi.org/10.1038/nprot.2009.127

CAS  Article  PubMed  PubMed Central  Google Scholar 

Ikuno T, Masumoto H, Yamamizu K, Yoshioka M, Minakata K, Ikeda T, Sakata R, Yamashita JK (2017) Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP. PLoS ONE 12:e0176238. https://doi.org/10.1371/journal.pone.0176238

Article  PubMed  PubMed Central  Google Scholar 

Iwamoto N, Kobayashi K, Kosaka K (1989) The formation of prostaglandins in the postmortem cerebral cortex of Alzheimer-type dementia patients. J Neurol 236:80–84. https://doi.org/10.1007/BF00314401

CAS  Article  PubMed  Google Scholar 

Jaiswal MK (2017) Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease. Neural Regen Res 12:723–736. https://doi.org/10.4103/1673-5374.206635

Article  PubMed  PubMed Central  Google Scholar 

Johann S, Dahm M, Kipp M, Zahn U, Beyer C (2011) Regulation of choline acetyltransferase expression by 17β-oestradiol in NSC-34 cells and in the spinal cord. J Neuroendocrinol 23:839–848. https://doi.org/10.1111/j.1365-2826.2011.02192.x

CAS  Article  PubMed  Google Scholar 

Kanakasabai S, Pestereva E, Chearwae W, Gupta SK, Ansari S, Bright JJ (2012) PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes. PLoS ONE 7:1–14. https://doi.org/10.1371/journal.pone.0050500

CAS  Article  Google Scholar 

Kihara Y, Matsushita T, Kita Y, Uematsu S, Akira S, Kira J, Ishii S, Shimizu T (2009) Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc Natl Acad Sci 106:21807–21812. https://doi.org/10.1073/pnas.0906891106

Article  PubMed  PubMed Central  Google Scholar 

Kim DK, Kweon KJ, Kim P, Kim HJ, Kim SS, Sohn NW, Maeng S, Shin JW (2017) Ginsenoside Rg3 improves recovery from spinal cord injury in rats via suppression of neuronal apoptosis, pro-inflammatory mediators, and microglial activation. Molecules 22:122. https://doi.org/10.3390/molecules22010122

CAS  Article  PubMed Central  Google Scholar 

Kim H, Zahir T, Tator CH, Shoichet MS (2011) Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS ONE 6:1–12. https://doi.org/10.1371/journal.pone.0021744

CAS  Article  Google Scholar 

Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122:217–224. https://doi.org/10.1038/sj.bjp.0701367

CAS  Article  PubMed  PubMed Central  Google Scholar 

Kondo M, Shibata T, Kumagai T, Osawa T, Shibata N, Kobayashi M, Sasaki S, Iwata M, Noguchi N, Uchida K (2002) 15-Deoxy-Delta(12,14)-prostaglandin J(2): The endogenous electrophile that induces neuronal apoptosis. Proc Natl Acad Sci U S A 99:7367–7372. https://doi.org/10.1073/pnas.112212599

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lee S, Cuvillier JM, Lee B, Shen R, Lee JW, Lee SK (2012) Fusion protein Isl1-Lhx3 specifies motor neuron fate by inducing motor neuron genes and concomitantly suppressing the interneuron programs. Proc Natl Acad Sci USA 109:3383–3388. https://doi.org/10.1073/pnas.1114515109

Article  PubMed  PubMed Central  Google Scholar 

Lee S, Lee B, Lee JW, Lee SK (2009) Retinoid signaling and Neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron 62:641–654. https://doi.org/10.1016/j.neuron.2009.04.025

CAS  Article  PubMed  PubMed Central  Google Scholar 

Lee SK, Lee B, Ruiz EC, Pfaff SL (2005) Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev 19:282–294. https://doi.org/10.1101/gad.1257105

CAS  Article  PubMed  PubMed Central