In 2008, the ICRP established for the first time its own voxelized reference phantoms for the adult male and adult female [10]. These phantoms were based upon CT imaging of height–weight matched patients and subsequently altered to specifically match reference values of organ mass given in ICRP Publication 89 [9]. The Publication 110 reference phantoms provide a detailed description of the human anatomy for a total of 79 source regions and 43 target regions [10].

The updated ICRP phantom regions reflect the ICRP’s focus on radiation protection. Accordingly, a number of new tissues and related anatomical details are intended to support organ dosimetry associated with inhaled or ingested radionuclides and their concomitant risks of radiation-induced stochastic bioeffects (e.g., cancer and hereditary effects). Although some of these regions may also be relevant source or target regions for radiopharmaceutical therapy, in certain circumstances a number of them are not. The respiratory tract and alimentary tract [12] models illustrate this difference in dosimetric purposes. The expanded versions of these two anatomical systems constitute more than half of the source regions listed in ICRP revised publications.

ICRP respiratory tract model

To study the effects of inhaled radioactivity, the morphological model of the respiratory tract is divided into five tissue regions associated with deposited radioactive aerosols along the walls of the respiratory airways [11]. These include ET1 (anterior nasal cavity), ET2 (posterior nasal cavity), BB (bronchial airways), bb (bronchiolar airways), and AI (alveolar interstitial region), which collectively define the human respiratory tract model (or HRTM).

The updated respiratory tract phantom geometry divides the respiratory tract into several individual source tissue regions into which inhaled radionuclides may deposit. Figure 1 shows the transition from source regions defined in the CE phantom to the morphological phantom developed by the ICRP. The regions of interest for nuclear medicine can be narrowed down to a subset of the regions constituting each section mentioned above. Figure 2 depicts the CE phantom lung regions and the corresponding regions in the ICRP phantom that are relevant to nuclear medicine. The figure was generated using the idea of Venn diagrams to illustrate overlapping regions. As seen by comparing the information on the models in Figs. 1 and 2, these are a subset of the comprehensive list of all source regions provided in the ICRP phantom (Appendix, Table 5).

Fig. 1

CE to ICRP transition for respiratory tract phantom geometry of source organs (figure adapted from ICRP publication 66 [11] and [6])

Fig. 2

CE respiratory tract source region correspondence to simplified ICRP respiratory tract model for applications in diagnosis and therapy

There are three regions in the ICRP phantom that are coincident with “lungs” as described in the CE phantom. These ICRP phantom regions are listed as: “lungs,” “alveolar interstitial (AI),” and “lung tissue.”

The region listed as “lung tissue” corresponds to all soft tissues within the lungs (e.g., lung parenchyma) but exclusive of all blood within the lungs (pulmonary arteries, capillaries, and veins). In contrast, the ICRP region listed as “lungs” includes both the lung tissue and its blood content. This distinction is relevant only for biokinetic modeling; in terms of S values, these two source regions are identical. Studies cited in ICRP Publication 66 suggest that blood represents about 58% of the mass of the lungs. The “AI” region is defined as the tissue region supporting the terminal bronchioles. It corresponds to the subregion of the lungs where oxygen and carbon dioxide exchange between the air in the lungs and the blood gases take place. This region is particularly relevant to dosimetry associated with inhaled radioactive particles or potentially to radioactive gas released from the circulation and thus a potential critical target region for emissions originating in adjacent source regions. The nasal passage wall is also associated with inhaled radioactive particles. The nasal passage is comprised of six regions; not all six regions are relevant in radiopharmaceutical therapy. Figure 3 represents the most appropriate target tissue mapping from the CE phantom to the ICRP phantom. The secretory and basal cells are the relevant targets for radiogenic lung cancer and thus they are used by the ICRP in their computation of “lung dose” for radioprotection. For RPT, however, a lung target most representative of the risk of lung fibrosis (or other deterministic effect) is more appropriate. The best ICRP target here would be “lung tissue” which, as noted above, corresponds to the lung parenchyma.

Fig. 3

CE to ICRP phantom correspondence (target tissues) for respiratory tract

Alimentary tract

The source regions in the alimentary tract are also differentiated to more explicitly identify tissues that encounter ingested activity (or activity that was inhaled and transferred to the alimentary tract via mucociliary clearance mechanisms). Numerous additional source regions have been defined as a result of alimentary tract phantom development; several of these tissues are not easily sampled either directly or by nuclear medicine imaging, but were included by the ICRP because they are part of their series of radionuclide biokinetic models [12]. This includes tissues in contact with activity due to subsequent transport from the GI tract to blood and organ secretions. Figure 4 shows the evolution of the alimentary tract model from the eight source regions in the CE model to the current ICRP model. In the CE phantom, the S values were calculated using Monte Carlo simulation for radionuclide disintegrations occurring only within organ contents. For the small intestine, however, there is no geometric separation between the SI wall and SI content in the CE phantoms. By contrast, the ICRP Monte Carlo simulations were performed for disintegrations occurring within both the GI tract walls (specifically their mucosal layer) and the contents of the GI tract lumen. Furthermore, the regions are redefined in the ICRP phantom so that the large intestine (LI) is no longer divided into upper large intestine (ULI) and lower large intestine (LLI). Instead, these regions are now redefined as left colon (LC), right colon (RC), and rectosigmoid colon (RS) (Fig. 4), a division that better matches experimental data on content transit times.

Fig. 4

CE to ICRP phantom correspondence (source regions) for the alimentary tract. *Organs which indirectly contribute to the functioning of the alimentary tract

The ICRP’s alimentary tract model of Publication 100 [12], which is implemented in the Publication 110 adult phantoms, has additional source regions including the esophagus, teeth, oral cavity, and salivary glands. A portion of the activity in the oral cavity may also be apportioned to oral mucosa. The “salivary glands” source region is comprised of six anatomical regions—the left and right parotid, submandibular, and sublingual glands.

The esophageal wall, oral cavity mucosal lining, teeth surface, and salivary glands are the relevant source or target tissues for absorbed dose calculations in nuclear medicine therapy and diagnosis.

The colon (or large intestines in the CE nomenclature) regions that are defined in the ICRP phantom differ from those in the CE phantom. To transition from the CE to the ICRP phantom, the total activity (ULI + LLI) obtained from the CE phantom is apportioned to the three coincident regions based on their relative masses in the ICRP model. Some other common source and target regions in both the phantoms as shown in Fig. 4 are the kidneys, pancreas, liver, gall bladder, and adrenals.

Table 1 lists the mass and factors required for an equivalent mapping. Assuming a uniform distribution of activity throughout the colon, the mapping factor times the time integrated activity (TIA) or time integrated activity coefficient (TIAC) in the large intestines gives the TIA or TIAC in the corresponding ICRP source regions.

Table 1 Mapping factor to transition from CE to ICRP model

The ICRP phantom alimentary tract includes target regions deemed important in their impact on overall tissue response to radiation. These include the oral mucosa, and the stem cell layers within the mucosal layers of the stomach, small intestine, and large intestine walls. Figure 5 illustrates the corresponding target regions for the CE and ICRP phantoms. In addition to the regions displayed in the figure, ICRP phantom includes the tongue, tonsils, and salivary glands.

Fig. 5

CE to ICRP phantom correspondence (target regions) for the alimentary tract. *Organs which indirectly contribute to the functioning of the alimentary tract

Skeletal tissues

The active marrow, inactive marrow, trabecular and cortical bone are included as source regions in the ICRP phantom’s skeletal system representation. The active marrow is the only marrow source region considered in the original CE phantom.

The definition of bone endosteum has evolved over time. In the ICRP Publication70 model [13], bone endosteum was defined as a single cell layer (10 microns in thickness) along all surfaces of bone trabeculae in trabecular bone, and along the surfaces of the Haversian canals of cortical bone.

With the development of the ICRP 110 adult phantoms, the ICRP changed this target tissue (for radiogenic bone cancer risk [14]) to include a 50-micron region of bone marrow along the surfaces of the bone trabeculae, and a 50-micron layer of marrow along the inner bone shafts of the long bones. Cortical bone is no longer considered to house “endosteum” and thus is only a radiation source region and consequently is no longer a component of the endosteum target region.

To summarize, the endosteum layer in the ICRP phantom and the osteogenic layer in the CE phantom are the corresponding target regions for the skeletal system. The active marrow is another target region common to both the CE and ICRP phantoms. Both phantoms have an endosteum as a target—but this target is anatomically/histologically different in the two phantoms (Fig. 6).

Fig. 6

CE to ICRP phantom correspondence in skeletal system

Other source and target regions

The spleen, thymus, thyroid, ovaries, testes, uterus, brain, breast, and heart are common as source regions in both the ICRP and CE phantoms. In the CE phantom, the heart was divided into its contents and wall. The ICRP phantom includes the heart wall as a source region; it does not have an explicit heart contents source region since total body blood is included as a distinct source region [9]. The lens of the eye, pituitary gland, tonsils, prostate, salivary glands (including the parotid, submandibular and sublingual), teeth, oral cavity, adipose tissue, and the ureters are new and additional source regions defined within the ICRP adult phantom. Some of these are important in radionuclide therapy dosimetry.

Similarly, there are a few other common target regions included in both models; these are listed in the Appendix. There exist additional target regions corresponding to the additional source tissue in the ICRP adult phantom resulting in a total of 43 target regions.

The CE phantom has a “residual soft tissue (RST)” region corresponding to interior regions of the phantoms that are not already taken by other organs within the body. This RST region is used as a surrogate for “muscle” as a source region and as a target region. In the ICRP phantoms, however, explicit geometric models for both “muscle” and “adipose” tissue are defined; there are no undefined regions in the ICRP phantoms, as there are in the CE phantoms. RST in the CE phantom would correspond to both muscle and adipose tissue in the ICRP phantoms. ICRP categorizes 41 source tissue as “other tissue source” regions which are potential candidates for inclusion in whole body reminder calculation usually performed for RPT dosimetry applications.

Target mass differences

Target mass differences will impact the absorbed dose comparison. Table 2 summarizes the target region masses for the two different phantoms. The GI tract targets in the CE phantom were entire organ walls, while in the ICRP phantoms they are stem cell layers embedded at depth within only the outer mucosal layer of the GI tract walls.

Table 2 CE phantom to ICRP phantom mapping for major alimentary tract target tissuesBlood as source region

To facilitate biokinetic modeling wherein a central blood pool is a distinct physiologic compartment, the ICRP phantom considers blood as a distinct source region. Accordingly, source regions correspond to and are assigned the mass of tissue parenchyma. Activity in blood also contributes to the total organ activity, and thus the organ self-doses and cross-doses. Source region activity values estimated from nuclear medicine imaging will include activity in the whole organ (blood + parenchyma). Using a measured blood value directly would lead to double counting of the blood in such regions since source region activity measured from the images includes both the radiopharmaceutical activity in the organ parenchyma as well as the radiopharmaceutical activity within the blood pool of that same organ. This can be avoided by subtracting the fraction of total body blood activity that is localized within the blood pool of the organ of interest (based upon reference blood distribution models [15]). The CE phantom does not include blood as a source organ except for (1) the heart contents region and (2) the major inter-organ veins and arteries. There are no explicit models of intra-organ blood vessels in the organs of the Publication 110 reference voxel phantoms.

Suggested limitations on the simultaneous use of source regions

The ICRP phantom includes several source regions that overlap to allow modeling of radionuclides that distribute by different mechanisms. Some of these source regions should not be used together as they overlap. Other structures, including volume and surface sources for some regions, would not normally be used together if the data came from imaging or tissue sampling, but might be based on modeling. Table 3 gives a list of the cases where such limitations make sense.

Table 3 Suggested use on simultaneous use of source regions