Cosgrove J, Hustin LSP, de Boer RJ, Perié L. Hematopoiesis in numbers. Trends Immunol. 2021;42(12):1100–12.

CAS  PubMed  Article  Google Scholar 

Newell LF, Cook RJ. Advances in acute myeloid leukemia. BMJ. 2021;375: n2026.

PubMed  Article  Google Scholar 

Venney D, Mohd-Sarip A, Mills KI. The impact of epigenetic modifications in myeloid malignancies. Int J Mol Sci. 2021;22(9):5013.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bullinger L, Döhner K, Döhner H. Genomics of acute myeloid leukemia diagnosis and pathways. J Clin Oncol. 2017;35(9):934–46.

CAS  PubMed  Article  Google Scholar 

Abdel-Wahab O, Levine RL. Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood. 2013;121(18):3563–72.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Yang X, Wong MPM, Ng RK. Aberrant DNA methylation in acute myeloid leukemia and its clinical implications. Int J Mol Sci. 2019;20(18):4576.

CAS  PubMed Central  Article  Google Scholar 

Kayser S, Levis MJ. Updates on targeted therapies for acute myeloid leukaemia. Br J Haematol. 2022. https://doi.org/10.1111/bjh.17746.

Article  PubMed  Google Scholar 

Merlo GR, Zerega B, Paleari L, Trombino S, Mantero S, Levi G. Multiple functions of Dlx genes. Int J Dev Biol. 2000;44(6):619–26.

CAS  PubMed  Google Scholar 

Lou Y, Fallah Y, Yamane K, Berg PE. BP1, a potential biomarker for breast cancer prognosis. Biomark Med. 2018;12(5):535–45.

CAS  PubMed  Article  Google Scholar 

Cavalli LR, Man YG, Schwartz AM, Rone JD, Zhang Y, Urban CA, Lima RS, Haddad BR, Berg PE. Amplification of the BP1 homeobox gene in breast cancer. Cancer Genet Cytogenet. 2008;187(1):19–24.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Schwartz AM, Man YG, Rezaei MK, Simmens SJ, Berg PE. BP1, a homeoprotein, is significantly expressed in prostate adenocarcinoma and is concordant with prostatic intraepithelial neoplasia. Mod Pathol. 2009;22(1):1–6.

CAS  PubMed  Article  Google Scholar 

Fu SW, Schwartz A, Stevenson H, Pinzone JJ, Davenport GJ, Orenstein JM, Gutierrez P, Simmens SJ, Abraham J, Poola I, Stephan DA, Berg PE. Correlation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancer. Breast Cancer Res. 2003;5(4):R82–7.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Man YG, Fu SW, Schwartz A, Pinzone JJ, Simmens SJ, Berg PE. Expression of BP1, a novel homeobox gene, correlates with breast cancer progression and invasion. Breast Cancer Res Treat. 2005;90(3):241–7.

CAS  PubMed  Article  Google Scholar 

Man YG, Schwartz A, Levine PH, Teal C, Berg PE. BP1, a putative signature marker for inflammatory breast cancer and tumor aggressiveness. Cancer Biomark. 2009;5(1):9–17.

CAS  PubMed  Article  Google Scholar 

Yu M, Yang Y, Shi Y, Wang D, Wei X, Zhang N, Niu R. Expression level of beta protein 1 mRNA in Chinese breast cancer patients: a potential molecular marker for poor prognosis. Cancer Sci. 2008;99(1):173–8.

CAS  PubMed  Google Scholar 

Gao Y, Li Z, Guo X, Liu Y, Zhang K. DLX4 as a prognostic marker for hepatocellular carcinoma. Neoplasma. 2014;61(3):318–23.

CAS  PubMed  Article  Google Scholar 

Yu M, Wan Y, Zou Q. Prognostic significance of BP1 mRNA expression level in patients with non-small cell lung cancer. Clin Biochem. 2008;41(10–11):824–30.

CAS  PubMed  Article  Google Scholar 

Haga SB, Fu S, Karp JE, Ross DD, Williams DM, Hankins WD, Behm F, Ruscetti FW, Chang M, Smith BD, Becton D, Raimondi SC, Berg PE. BP1, a new homeobox gene, is frequently expressed in acute leukemias. Leukemia. 2000;14(11):1867–75.

CAS  PubMed  Article  Google Scholar 

Rauch TA, Wang Z, Wu X, Kernstine KH, Riggs AD, Pfeifer GP. DNA methylation biomarkers for lung cancer. Tumour Biol. 2012;33(2):287–96.

CAS  PubMed  Article  Google Scholar 

Miyamoto K, Fukutomi T, Akashi-Tanaka S, Hasegawa T, Asahara T, Sugimura T, Ushijima T. Identification of 20 genes aberrantly methylated in human breast cancers. Int J Cancer. 2005;116(3):407–14.

CAS  PubMed  Article  Google Scholar 

Tong WG, Wierda WG, Lin E, Kuang SQ, Bekele BN, Estrov Z, Wei Y, Yang H, Keating MJ, Garcia-Manero G. Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact. Epigenetics. 2010;5(6):499–508.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Harada H, Miyamoto K, Yamashita Y, Taniyama K, Ohdan H, Okada M. Methylated DLX4 predicts response to pathologic stage I non-small cell lung cancer resection. Ann Thorac Surg. 2015;99(5):1746–54.

PubMed  Article  Google Scholar 

Sakane J, Taniyama K, Miyamoto K, Saito A, Kuraoka K, Nishimura T, Sentani K, Oue N, Yasui W. Aberrant DNA methylation of DLX4 and SIM1 is a predictive marker for disease progression of uterine cervical low-grade squamous intraepithelial lesion. Diagn Cytopathol. 2015;43(6):462–70.

PubMed  Article  Google Scholar 

Zhang TJ, Zhou JD, Yang DQ, Wang YX, Yao DM, Ma JC, Wen XM, Guo H, Lin J, Qian J. Hypermethylation of DLX4 predicts poor clinical outcome in patients with myelodysplastic syndrome. Clin Chem Lab Med. 2016;54(5):865–71.

CAS  PubMed  Article  Google Scholar 

Zhou JD, Zhang TJ, Wang YX, Yang DQ, Yang L, Ma JC, Wen XM, Yang J, Lin J, Qian J. DLX4 hypermethylation is a prognostically adverse indicator in de novo acute myeloid leukemia. Tumour Biol. 2016;37(7):8951–60.

CAS  PubMed  Article  Google Scholar 

Zhou JD, Wang YX, Zhang TJ, Yang DQ, Yao DM, Guo H, Yang L, Ma JC, Wen XM, Yang J, Lin J, Qian J. Epigenetic inactivation of DLX4 is associated with disease progression in chronic myeloid leukemia. Biochem Biophys Res Commun. 2015;463(4):1250–6.

CAS  PubMed  Article  Google Scholar 

Zhou JD, Yang J, Guo H, Deng ZQ, Wen XM, Yang L, Yin JY, Xiao GF, Lin J, Qian J. BP1 overexpression is associated with adverse prognosis in de novo acute myeloid leukemia. Leuk Lymphoma. 2016;57(4):828–34.

CAS  PubMed  Article  Google Scholar 

Zhou JD, Zhang TJ, Xu ZJ, Deng ZQ, Gu Y, Ma JC, Wen XM, Leng JY, Lin J, Chen SN, Qian J. Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes. Cell Death Dis. 2020;11(11):997.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Zhang TJ, Xu ZJ, Gu Y, Wen XM, Ma JC, Zhang W, Deng ZQ, Leng JY, Qian J, Lin J, Zhou JD. Identification and validation of prognosis-related DLX5 methylation as an epigenetic driver in myeloid neoplasms. Clin Transl Med. 2020;10(2): e29.

PubMed  PubMed Central  Google Scholar 

Zhang TJ, Xu ZJ, Gu Y, Ma JC, Wen XM, Zhang W, Deng ZQ, Qian J, Lin J, Zhou JD. Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia. Clin Epigenetics. 2021;13(1):16.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Halabian R, Ahmadi A, Saeedi P, Azimzadeh Jamalkandi S, Alivand MR. Laboratory methods to decipher epigenetic signatures: a comparative review. Cell Mol Biol Lett. 2021;26(1):46.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Xu F, Wu LY, Chang CK, He Q, Zhang Z, Liu L, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X. Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes. Nat Commun. 2015;6:8806.

CAS  PubMed  Article  Google Scholar 

Zhang L, Yang M, Gan L, He T, Xiao X, Stewart MD, Liu X, Yang L, Zhang T, Zhao Y, Fu J. DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis. Int J Biol Sci. 2012;8(8):1178–87.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fu Y, Lian Y, Kim KS, Zhang L, Hindle AK, Brody F, Siegel RS, McCaffrey TA, Fu SW. BP1 homeoprotein enhances metastatic potential in ER-negative breast cancer. J Cancer. 2010;1:54–62.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Haria D, Trinh BQ, Ko SY, Barengo N, Liu J, Naora H. The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer. Am J Pathol. 2015;185(8):2298–308.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Sun G, Ge Y, Zhang Y, Yan L, Wu X, Ouyang W, Wang Z, Ding B, Zhang Y, Long G, Liu M, Shi R, Zhou H, Chen Z, Ye Z. Transcription factors BARX1 and DLX4 contribute to progression of clear cell renal cell carcinoma via promoting proliferation and epithelial-mesenchymal transition. Front Mol Biosci. 2021;8: 626328.

CAS  PubMed  PubMed Central  Article