Smadja DM, Mentzer SJ, Fontenay M, Laffan MA, Ackermann M, Helms J, Jonigk D, Chocron R, Pier GB, Gendron N, Pons S, Diehl JL, Margadant C, Guerin C, Huijbers EJM, Philippe A, Chapuis N, Nowak-Sliwinska P, Karagiannidis C, Sanchez O, Kumpers P, Skurnik D, Randi AM, Griffioen AW (2021) COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis. https://doi.org/10.1007/s10456-021-09805-6
Article PubMed PubMed Central Google Scholar
Goldsmith CS, Miller SE, Martines RB, Bullock HA, Zaki SR (2020) Electron microscopy of SARS-CoV-2: a challenging task. The Lancet 395(10238):e99. https://doi.org/10.1016/S0140-6736(20)31188-0
McCracken IR, Saginc G, He L, Huseynov A, Daniels A, Fletcher S, Peghaire C, Kalna V, Andaloussi-Mäe M, Muhl L, Craig NM, Griffiths SJ, Haas JG, Tait-Burkard C, Lendahl U, Birdsey GM, Betsholtz C, Noseda M, Baker AH, Randi AM (2021) Lack of evidence of ACE2 expression and replicative infection by SARSCoV-2 in human endothelial cells. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.120.052824
Article PubMed PubMed Central Google Scholar
Bradley BT, Maioli H, Johnston R, Chaudhry I, Fink SL, Xu H, Najafian B, Deutsch G, Lacy JM, Williams T, Yarid N, Marshall DA (2020) Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series. Lancet 396(10247):320–332. https://doi.org/10.1016/S0140-6736(20)31305-2
CAS Article PubMed PubMed Central Google Scholar
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan. China Lancet 395(10223):497–506
Smadja DM, Guerin CL, Chocron R, Yatim N, Boussier J, Gendron N, Khider L, Hadjadj J, Goudot G, Debuc B, Juvin P, Hauw-Berlemont C, Augy J-L, Peron N, Messas E, Planquette B, Sanchez O, Charbit B, Gaussem P, Duffy D, Terrier B, Mirault T, Diehl J-L (2020) Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients. Angiogenesis 23(4):611–620. https://doi.org/10.1007/s10456-020-09730-0
CAS Article PubMed Google Scholar
Bermejo-Martin JF, Gonzalez-Rivera M, Almansa R, Micheloud D, Tedim AP, Dominguez-Gil M, Resino S, Martin-Fernandez M, Ryan Murua P, Perez-Garcia F, Tamayo L, Lopez-Izquierdo R, Bustamante E, Aldecoa C, Gomez JM, Rico-Feijoo J, Orduna A, Mendez R, Fernandez Natal I, Megias G, Gonzalez-Estecha M, Carriedo D, Doncel C, Jorge N, Ortega A, de la Fuente A, Del Campo F, Fernandez-Ratero JA, Trapiello W, Gonzalez-Jimenez P, Ruiz G, Kelvin AA, Ostadgavahi AT, Oneizat R, Ruiz LM, Miguens I, Gargallo E, Munoz I, Pelegrin S, Martin S, Garcia Olivares P, Cedeno JA, Ruiz Albi T, Puertas C, Berezo JA, Renedo G, Herran R, Bustamante-Munguira J, Enriquez P, Cicuendez R, Blanco J, Abadia J, Gomez Barquero J, Mamolar N, Blanca-Lopez N, Valdivia LJ, Fernandez Caso B, Mantecon MA, Motos A, Fernandez-Barat L, Ferrer R, Barbe F, Torres A, Menendez R, Eiros JM, Kelvin DJ (2020) Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19. Crit Care 24(1):691. https://doi.org/10.1186/s13054-020-03398-0
Article PubMed PubMed Central Google Scholar
Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ (2020) Circulating markers of angiogenesis and endotheliopathy in COVID-19. Pulm Circ 10(4):2045894020966547
Rovas A, Osiaevi I, Buscher K, Sackarnd J, Tepasse PR, Fobker M, Kuhn J, Braune S, Gobel U, Tholking G, Groschel A, Pavenstadt H, Vink H, Kumpers P (2020) Microvascular dysfunction in COVID-19: the MYSTIC study. Angiogenesis. https://doi.org/10.1007/s10456-020-09753-7
Article PubMed PubMed Central Google Scholar
Smadja DM, Philippe A, Bory O, Gendron N, Beauvais A, Gruest M, Peron N, Khider L, Guerin CL, Goudot G, Levavasseur F, Duchemin J, Pene F, Cheurfa C, Szwebel TA, Sourdeau E, Planquette B, Hauw-Berlemont C, Hermann B, Gaussem P, Samama CM, Mirault T, Terrier B, Sanchez O, Rance B, Fontenay M, Diehl JL, Chocron R (2021) Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality. J Thromb Haemost. https://doi.org/10.1111/jth.15339
Article PubMed PubMed Central Google Scholar
Rauch A, Dupont A, Goutay J, Caplan M, Staessens S, Moussa M, Jeanpierre E, Corseaux D, Lefevre G, Lassalle F, Faure K, Lambert M, Duhamel A, Labreuche J, Garrigue D, De Meyer SF, Staels B, Van Belle E, Vincent F, Kipnis E, Lenting PJ, Poissy J, Susen S, Lille CRN, Members of the LSC (2020) Endotheliopathy is induced by plasma from critically ill patients and associated with organ failure in severe COVID-19. Circulation 142(19):1881–1884. https://doi.org/10.1161/CIRCULATIONAHA.120.050907
CAS Article PubMed PubMed Central Google Scholar
Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro NI, Duranteau J, Pinsky MR, Artigas A, Teboul JL, Reiss IKM, Aldecoa C, Hutchings SD, Donati A, Maggiorini M, Taccone FS, Hernandez G, Payen D, Tibboel D, Martin DS, Zarbock A, Monnet X, Dubin A, Bakker J, Vincent JL, Scheeren TWL (2018) Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine. Intensive Care Med 44(3):281–299. https://doi.org/10.1007/s00134-018-5070-7
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8):801–810. https://doi.org/10.1001/jama.2016.0287
CAS Article PubMed PubMed Central Google Scholar
Drost CC, Rovas A, Kusche-Vihrog K, Van Slyke P, Kim H, Hoang VC, Maynes JT, Wennmann DO, Pavenstadt H, Linke W, Lukasz A, Hesse B, Kumpers P (2019) Tie2 activation promotes protection and reconstitution of the endothelial glycocalyx in human sepsis. Thromb Haemost 119(11):1827–1838. https://doi.org/10.1055/s-0039-1695768
Rovas A, Seidel LM, Vink H, Pohlkotter T, Pavenstadt H, Ertmer C, Hessler M, Kumpers P (2019) Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Crit Care 23(1):260. https://doi.org/10.1186/s13054-019-2542-2
Article PubMed PubMed Central Google Scholar
Rovas A, Lukasz AH, Vink H, Urban M, Sackarnd J, Pavenstadt H, Kumpers P (2018) Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit: the GlycoNurse study. Scand J Trauma Resusc Emerg Med 26(1):16. https://doi.org/10.1186/s13049-018-0483-4
Article PubMed PubMed Central Google Scholar
Rovas A, Sackarnd J, Rossaint J, Kampmeier S, Pavenstadt H, Vink H, Kumpers P (2021) Identification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study. Crit Care 25(1):112. https://doi.org/10.1186/s13054-021-03520-w
Article PubMed PubMed Central Google Scholar
Diez-Silva M, Dao M, Han J, Lim CT, Suresh S (2010) Shape and biomechanical characteristics of human red blood cells in health and disease. MRS Bull 35(5):382–388. https://doi.org/10.1557/mrs2010.571
CAS Article PubMed PubMed Central Google Scholar
Assarsson E, Lundberg M, Holmquist G, Bjorkesten J, Thorsen SB, Ekman D, Eriksson A, Rennel Dickens E, Ohlsson S, Edfeldt G, Andersson AC, Lindstedt P, Stenvang J, Gullberg M, Fredriksson S (2014) Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability. PLoS ONE 9(4):e95192. https://doi.org/10.1371/journal.pone.0095192
CAS Article PubMed PubMed Central Google Scholar
Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Gerszten RE, Heimberg GS, Hoover PJ, Lieb DJ, Lin B, Ngo D, Pelka K, Reyes M, Smillie CS, Waghray A, Wood TE, Zajac AS, Jennings LL, Grundberg I, Bhattacharyya RP, Parry BA, Villani AC, Sade-Feldman M, Hacohen N, Goldberg MB (2021) Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions. Cell Rep Med 2(5):100287. https://doi.org/10.1016/j.xcrm.2021.100287
Article PubMed PubMed Central Google Scholar
Metsalu T, Vilo J (2015) ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. Nucleic Acids Res 43(W1):W566-570. https://doi.org/10.1093/nar/gkv468
CAS Article PubMed PubMed Central Google Scholar
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK (2019) Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun 10(1):1523. https://doi.org/10.1038/s41467-019-09234-6
CAS Article PubMed PubMed Central Google Scholar
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498–2504. https://doi.org/10.1101/gr.1239303
CAS Article PubMed PubMed Central Google Scholar
Del Valle DM, Kim-Schulze S, Huang HH, Beckmann ND, Nirenberg S, Wang B, Lavin Y, Swartz TH, Madduri D, Stock A, Marron TU, Xie H, Patel M, Tuballes K, Van Oekelen O, Rahman A, Kovatch P, Aberg JA, Schadt E, Jagannath S, Mazumdar M, Charney AW, Firpo-Betancourt A, Mendu DR, Jhang J, Reich D, Sigel K, Cordon-Cardo C, Feldmann M, Parekh S, Merad M, Gnjatic S (2020) An inflammatory cytokine signature predicts COVID-19 severity and survival. Nat Med 26(10):1636–1643. https://doi.org/10.1038/s41591-020-1051-9
CAS Article PubMed PubMed Central Google Scholar
Wilson JG, Simpson LJ, Ferreira AM, Rustagi A, Roque J, Asuni A, Ranganath T, Grant PM, Subramanian A, Rosenberg-Hasson Y, Maecker HT, Holmes SP, Levitt JE, Blish CA, Rogers AJ (2020) Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis. JCI Insight. https://doi.org/10.1172/jci.insight.140289
Article PubMed PubMed Central Google Scholar
Dong X, Wang C, Liu X, Gao W, Bai X, Li Z (2020) Lessons learned comparing immune system alterations of bacterial sepsis and SARS-CoV-2 sepsis. Front Immunol 11:598404. https://doi.org/10.3389/fimmu.2020.598404
CAS Article PubMed PubMed Central Google Scholar
Kox M, Frenzel T, Schouten J, van de Veerdonk FL, Koenen H, Pickkers P, Group obotRCIC-s (2020) COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients. Crit Care 24(1):263. https://doi.org/10.1186/s13054-020-02896-5
Article PubMed PubMed Central Google Scholar
de Roquetaillade C, Mansouri S, Brumpt C, Neuwirth M, Voicu S, Le Dorze M, Fontaine C, Barthelemy R, Gayat E, Megarbane B, Mebazaa A, Chousterman BG (2021) Comparison of circulating immune cells profiles and kinetics between coronavirus disease 2019 and bacterial sepsis. Crit Care Med. https://doi.org/10.1097/CCM.0000000000005088
留言 (0)