Macrophage-Myofibroblast Transition

In article number 2101235 Philip Chiu-Tsun Tang, Patrick Ming-Kuen Tang, Hui-Yao Lan, and co-workers discovered that tumor-associated macrophages are capable for de novo generating pathogenic cancer-associated fibroblasts via a direct mechanism macrophage-myofibroblast transition (MMT), representing a novel therapeutic target in the tumor microenvironment of solid cancers. Here, the macrophages undergoing MMT were coexpressing CAF (α-SMA, red) and macrophage marker (F4/80, green) with nuclei staining (blue), visualized by immunofluorescence with an experimental Lewis lung carcinoma (LLC) model.