1. Riddington, DW, Venkatesh, B, Boivin, CM, Bonser, RS, Elliott, TS, Marshall, T, Mountford, PJ, Bion, JF. Intestinal permeability, gastric intramucosal pH, and systemic endotoxemia in patients undergoing cardiopulmonary bypass. Jama 1996; 275:1007–12
Google Scholar | Crossref | Medline | ISI2. Aydin, NB, Gercekoglu, H, Aksu, B, Ozkul, V, Sener, T, Kiygil, I, Turkoglu, T, Cimen, S, Babacan, F, Demirtas, M. Endotoxemia in coronary artery bypass surgery: a comparison of the off-pump technique and conventional cardiopulmonary bypass. J Thorac Cardiovasc Surg 2003; 125:843–8
Google Scholar | Crossref | Medline | ISI3. Hirata, Y. Cardiopulmonary bypass for pediatric cardiac surgery. Gen Thorac Cardiovasc Surg 2018; 66:65–70
Google Scholar | Crossref | Medline4. Chawla, BK, Teitelbaum, DH. Profound systemic inflammatory response syndrome following non-emergent intestinal surgery in children. J Pediatr Surg 2013; 48:1936–40
Google Scholar | Crossref | Medline5. Osuka, A, Kusuki, H, Matsuura, H, Shimizu, K, Ogura, H, Ueyama, M. Acute intestinal damage following severe burn correlates with the development of multiple organ dysfunction syndrome: a prospective cohort study. Burns 2017; 43:824–9
Google Scholar | Crossref | Medline6. Geissler, HJ, Fischer, UM, Grunert, S, Kuhn-Régnier, F, Hoelscher, A, Schwinger, RH, Mehlhorn, U, Hekmat, K. Incidence and outcome of gastrointestinal complications after cardiopulmonary bypass. Interact Cardiovasc Thorac Surg 2006; 5:239–2342
Google Scholar | Crossref | Medline7. Hashemzadeh, K, Hashemzadeh, S. Predictors and outcome of gastrointestinal complications after cardiac surgery. Minerva Chir 2012; 67:327–35
Google Scholar | Medline8. Mojcik, CF, Levy, JH. Aprotinin and the systemic inflammatory response after cardiopulmonary bypass. Ann Thorac Surg 2001; 71:745–54
Google Scholar | Crossref | Medline | ISI9. Thorén, A, Nygren, A, Houltz, E, Ricksten, SE. Cardiopulmonary bypass in humans–jejunal mucosal perfusion increases in parallel with well-maintained microvascular hematocrit. Acta Anaesthesiol Scand 2005; 49:502–9
Google Scholar | Crossref | Medline10. Sack, FU, Reidenbach, B, Schledt, A, Dollner, R, Taylor, S, Gebhard, MM, Hagl, S. Dopexamine attenuates microvascular perfusion injury of the small bowel in pigs induced by extracorporeal circulation. Br J Anaesth 2002; 88:841–7
Google Scholar | Crossref | Medline11. Gyires, K, Zádori, ZS, Shujaa, N, Minorics, R, Falkay, G, Mátyus, P. Analysis of the role of Central and peripheral alpha2-adrenoceptor subtypes in gastric mucosal defense in the rat. Neurochem Int 2007; 51:289–96
Google Scholar | Crossref | Medline12. Müllner, K, Rónai, AZ, Fülöp, K, Fürst, S, Gyires, K. Involvement of central K(ATP) channels in the gastric antisecretory action of alpha2-adrenoceptor agonists and beta-endorphin in rats. Eur J Pharmacol 2002; 435:225–9
Google Scholar | Crossref | Medline13. Gyires, K, Müllner, K, Rónai, AZ. Functional evidence that gastroprotection can be induced by activation of central alpha(2B)-adrenoceptor subtypes in the rat. Eur J Pharmacol 2000; 396:131–5
Google Scholar | Crossref | Medline14. Asai, T, Mapleson, WW, Power, I. Differential effects of clonidine and dexmedetomidine on gastric emptying and gastrointestinal transit in the rat. Br J Anaesth 1997; 78:301–7
Google Scholar | Crossref | Medline15. Umezawa, T, Guo, S, Jiao, Y, Hisamitsu, T. Effect of clonidine on colonic motility in rats. Auton Neurosci 2003; 107:32–6
Google Scholar | Crossref | Medline16. Mantz, J, Josserand, J, Hamada, S. Dexmedetomidine: new insights. Eur J Anaesthesiol 2011; 28:3–6
Google Scholar | Crossref | Medline | ISI17. Xianbao, L, Hong, Z, Xu, Z, Chunfang, Z, Dunjin, C. Dexmedetomidine reduced cytokine release during postpartum bleeding-induced multiple organ dysfunction syndrome in rats. Mediators Inflamm 2013; 2013:627831
Google Scholar | Crossref | Medline | ISI18. Memiş, D, Hekimoğlu, S, Vatan, I, Yandim, T, Yüksel, M, Süt, N. Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients. Br J Anaesth 2007; 98:550–2
Google Scholar | Crossref | Medline19. Shi, QQ, Wang, H, Fang, H. Dose-response and mechanism of protective functions of selective alpha-2 agonist dexmedetomidine on acute lung injury in rats. Saudi Med J 2012; 33:375–81
Google Scholar | Medline20. Lai, YC, Tsai, PS, Huang, CJ. Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages. J Surg Res 2009; 154:212–9
Google Scholar | Crossref | Medline21. Sha, J, Zhang, H, Zhao, Y, Feng, X, Hu, X, Wang, C, Song, M, Fan, H. Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor. Toxicol Appl Pharmacol 2019; 364:144–52
Google Scholar | Crossref | Medline22. Zhang, X, Wang, J, Qian, W, Zhao, J, Sun, L, Qian, Y, Xiao, H. Dexmedetomidine inhibits tumor necrosis factor-alpha and interleukin 6 in lipopolysaccharide-stimulated astrocytes by suppression of c-Jun N-terminal kinases. Inflammation 2014; 37:942–9
Google Scholar | Crossref | Medline23. Qiao, H, Sanders, RD, Ma, D, Wu, X, Maze, M. Sedation improves early outcome in severely septic Sprague Dawley rats. Crit Care 2009; 13:R136
Google Scholar | Crossref | Medline | ISI24. Wu, Y, Liu, Y, Huang, H, Zhu, Y, Zhang, Y, Lu, F, Zhou, C, Huang, L, Li, X, Zhou, C. Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-κB pathway. Mediators Inflamm 2013; 2013:562154
Google Scholar | Crossref | Medline | ISI25. Hodge, DR, Hurt, EM, Farrar, WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005; 41:2502–12
Google Scholar | Crossref | Medline | ISI26. Schindler, C, Darnell, JE Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995; 64:621–51
Google Scholar | Crossref | Medline | ISI27. Chen, Y, Zhang, X, Zhang, B, He, G, Zhou, L, Xie, Y. Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug Des Devel Ther 2017; 11:2787–99
Google Scholar | Crossref | Medline28. Chen, K, Sun, W, Jiang, Y, Chen, B, Zhao, Y, Sun, J, Gong, H, Qi, R. Ginkgolide B suppresses TLR4-mediated inflammatory response by inhibiting the phosphorylation of JAK2/STAT3 and p38 MAPK in high glucose-treated HUVECs. Oxid Med Cell Longev 2017; 2017:9371602
Google Scholar | Crossref | Medline29. Pan, S, Chen, Y, Zhang, X, Xie, Y. The JAK2/STAT3 pathway is involved in dexmedetomidine-induced myocardial protection in rats undergoing cardiopulmonary bypass. Ann Transl Med 2020; 8:483
Google Scholar | Crossref | Medline30. Gourlay, T, Ballaux, PK, Draper, ER, Taylor, KM. Early experience with a new technique and technology designed for the study of pulsatile cardiopulmonary bypass in the rat. Perfusion 2002; 17:191–8
Google Scholar | SAGE Journals | ISI31. Zhang, X, Sun, Y, Song, D, Diao, Y. κ-opioid receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF-κB/HIF-1α pathway. Exp Ther Med 2020; 20:325–34
Google Scholar | Crossref | Medline32. Kalakech, H, Tamareille, S, Pons, S, Godin-Ribuot, D, Carmeliet, P, Furber, A, Martin, V, Berdeaux, A, Ghaleh, B, Prunier, F. Role of hypoxia inducible factor-1α in remote limb ischemic preconditioning. J Mol Cell Cardiol 2013; 65:98–104
Google Scholar | Crossref | Medline33. Long, Q, Fan, C, Kai, W, Luo, Q, Xin, W, Wang, P, Wang, A, Wang, Z, Han, R, Fei, Z, Qiu, B, Liu, W. Hypoxia inducible factor-1α expression is associated with hippocampal apoptosis during epileptogenesis. Brain Res 2014; 1590:20–30
Google Scholar | Crossref | Medline34. Fasano, A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol 2012; 10:1096–100
Google Scholar | Crossref | Medline35. Sun, YJ, Cao, HJ, Song, DD, Diao, YG, Zhou, J, Zhang, TZ. Probiotics can alleviate cardiopulmonary bypass-induced intestinal mucosa damage in rats. Dig Dis Sci 2013; 58:1528–36
Google Scholar | Crossref | Medline36. He, C, Deng, J, Hu, X, Zhou, S, Wu, J, Xiao, D, Darko, KO, Huang, Y, Tao, T, Peng, M, Wang, Z, Yang, X. Vitamin a inhibits the action of LPS on the intestinal epithelial barrier function and tight junction proteins. Food Funct 2019; 10:1235–42
Google Scholar | Crossref | Medline37. Sun, T, Liang, H, Xue, M, Liu, Y, Gong, A, Jiang, Y, Qin, Y, Yang, J, Meng, D. Protective effect and mechanism of fucoidan on intestinal mucosal barrier function in NOD mice. Food Agr Immunol 2020; 31:939–53
Google Scholar | Crossref38. Sun, YJ, Chen, WM, Zhang, TZ, Cao, HJ, Zhou, J. Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats. Wjg 2008; 14:5868–75
Google Scholar | Crossref | Medline39. Liu, Z, Sun, X, Tang, J, Tang, Y, Tong, H, Wen, Q, Liu, Y, Su, L. Intestinal inflammation and tissue injury in response to heat stress and cooling treatment in mice. Mol Med Rep 2011; 4:437–43
Google Scholar | Medline40. Chen, Y, Miao, L, Yao, Y, Wu, W, Wu, X, Gong, C, Qiu, L, Chen, J. Dexmedetomidine ameliorate CLP-induced rat intestinal injury via inhibition of inflammation. Mediators Inflamm 2015; 2015:918361
Google Scholar | Crossref | Medline41. Zhou, Z, Xu, MJ, Gao, B. Hepatocytes: a key cell type for innate immunity. Cell Mol Immunol 2016; 13:301–15
Google Scholar | Crossref | Medline42. Moore, KW, de Waal Malefyt, R, Coffman, RL, O'Garra, A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19:683–765
Google Scholar | Crossref | Medline | ISI43. Jo, HA, Kim, JY, Yang, SH, Han, SS, Joo, KW, Kim, YS, Kim, DK. The role of local IL6/JAK2/STAT3 signaling in high glucose-induced podocyte hypertrophy. Kidney Res Clin Pract 2016; 35:212–8
Google Scholar | Crossref | Medline44. Aroor, AR, McKarns, S, Demarco, VG, Jia, G, Sowers, JR. Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance. Metabolism 2013; 62:1543–52
Google Scholar | Crossref | Medline | ISI45. Li, M, Song, L, Gao, X, Chang, W, Qin, X. Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes. Exp Mol Med 2012; 44:260–7
Google Scholar | Crossref | Medline46. Ying, H, Da, L, Shi, Y, Xia, Y, Liu, L, Xie, L, Ren, W. TLR4 mediates MAPK-STAT3 axis activation in bladder epithelial cells. Inflammation 2013; 36:1064–74
Google Scholar | Crossref | Medline47. Song, D, Liu, X, Diao, Y, Sun, Y, Gao, G, Zhang, T, Chen, K, Pei, L. Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/akt signaling pathway during cardiopulmonary bypass in rats. Mol Med Rep 2018; 18:1925–38