SYSTEMATIC REVIEW article

Front. Immunol.

Sec. Mucosal Immunity

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1450798

Provisionally accepted

The final, formatted version of the article will be published soon.

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Serum Surfactant protein D (SP-D) is a potential biomarker for the non-invasive prediction of interstitial lung disease (ILD) status. However, previous studies lacked comprehensively qualitative and quantitative pooled analysis methods to summarize the relationship between SP-D and ILD.We conducted a comprehensive literature search from PubMed, Embase, web of science, Scopus, Ovid and Cochrane Library, up to 16 December 2023. The Newcastle-Ottawa Quality Assessment Scale was employed to evaluate the quality of each included study. Pooled analyses were primarily performed for weighted mean difference (WMD), odds ratio (OR) and hazard ratio (HR). Sensitivity analysis was conducted by sequentially eliminating one study at a time and reanalyzing the remaining studies. Besides, trim-and-fill method was applied for correcting publication bias.More than 3561 patients with ILD from 41 articles were included for pooled analysis.The pooled results showed that serum SP-D levels were higher in ILD group than control group (WMD = 120.24 ng/mL, 95% CI: 72.45-168.03, p

Keywords: Surfactant protein D, Interstitial Lung Disease, occurrence, progression, Acute exacerbation, Mortality

Received: 18 Jun 2024; Accepted: 27 Jan 2025.

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