Front. Cell. Infect. Microbiol.

Sec. Intestinal Microbiome

Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1549914

Provisionally accepted

The final, formatted version of the article will be published soon.

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The human gut microbiota (GM) is a complex and dynamic ecosystem that plays a pivotal role in benefiting human health and overall well-being. It maintains host physiological homeostasis through diverse host-microbe interactions, including immune modulation, antagonistic inhibition of pathogen colonization, and facilitation of nutrient absorption. Factors such as diet, antibiotic use, age and host genomics all contribute to the initiation and maintenance of GM diversity, with diet recognized as the most influential determinant. Dietary interventions can modulate the abundance of various bacterial species in the gut, thereby shaping health outcomes, through the consumption of dietary fiber, probiotics, prebiotics, synbiotics, etc. The aim of this Research Topic is to explore the molecular mechanisms of host-microbe interactions and investigate how dietary interventions influence human health and disease through the modulation of the GM.In this collection, we begin by presenting research focused on diabetes. As is well known, diabetes is a chronic metabolic disorder marked by elevated blood glucose levels, intricately linked to metabolic dysregulation and systemic inflammation. Impaired glucose tolerance (IGT) is a precursor state of diabetes. To

Keywords: Dietary interventions, Intestinal microbiota homeostasis, Dysbiosis, Probiotics/prebiotics/synbiotics, diabetes, host health

Received: 22 Dec 2024; Accepted: 23 Jan 2025.

Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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