Alberti S, Gladfelter A, Mittag T. Considerations and challenges in studying liquid-liquid phase separation and Biomolecular condensates. Cell. 2019;176:419–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tong X, Tang R, Xu J, Wang W, Zhao Y, Yu X, Shi S. Liquid-liquid phase separation in tumor biology. Signal Transduct Target Ther. 2022;7:221.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehta S, Zhang J. Liquid-liquid phase separation drives cellular function and dysfunction in cancer. Nat Rev Cancer. 2022;22:239–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Qin Z, Liu Y, Xia X, He L, Chen N, Hu X, Peng X. Liquid–liquid phase separation: roles and implications in future cancer treatment. Int J Biol Sci. 2023;19:4139–56.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boyko S, Surewicz WK. Tau liquid-liquid phase separation in neurodegenerative diseases. Trends Cell Biol. 2022;32:611–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chau BA, Chen V, Cochrane AW, Parent LJ, Mouland AJ. Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication. Cell Rep. 2023;42:111968.

Article  CAS  PubMed  Google Scholar 

Jiang S, Fagman JB, Chen C, Alberti S, Liu B. Protein phase separation and its role in tumorigenesis. Elife 2020, 9.

Xu WX, Qu Q, Zhuang HH, Teng XQ, Wei YW, Luo J, Dai YH, Qu J. The burgeoning significance of liquid-liquid phase separation in the Pathogenesis and therapeutics of cancers. Int J Biol Sci. 2024;20:1652–68.

Article  PubMed  PubMed Central  Google Scholar 

Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, et al. Phase separation drives aberrant chromatin looping and cancer development. Nature. 2021;595:591–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banani SF, Lee HO, Hyman AA, Rosen MK. Biomolecular condensates: organizers of cellular biochemistry. Nat Rev Mol Cell Biol. 2017;18:285–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lafontaine DLJ, Riback JA, Bascetin R, Brangwynne CP. The nucleolus as a multiphase liquid condensate. Nat Rev Mol Cell Biol. 2021;22:165–82.

Article  CAS  PubMed  Google Scholar 

Yoneda M, Nakagawa T, Hattori N, Ito T. The nucleolus from a liquid droplet perspective. J Biochem. 2021;170:153–62.

Article  CAS  PubMed  Google Scholar 

Carotenuto P, Pecoraro A, Palma G, Russo G, Russo A. Therapeutic approaches targeting Nucleolus in Cancer. Cells 2019, 8.

Ren J, Yu P, Liu S, Li R, Niu X, Chen Y, Zhang Z, Zhou F, Zhang L. Deubiquitylating enzymes in Cancer and Immunity. Adv Sci (Weinh). 2023;10:e2303807.

Article  PubMed  Google Scholar 

Tu R, Ma J, Zhang P, Kang Y, Xiong X, Zhu J, Li M, Zhang C. The emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism. Cancer Cell Int. 2022;22:130.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan WC, Liu X, Magin RS, Girardi NM, Ficarro SB, Hu W, Tarazona Guzman MI, Starnbach CA, Felix A, Adelmant G, et al. Accelerating inhibitor discovery for deubiquitinating enzymes. Nat Commun. 2023;14:686.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji S, Luo Y, Cai Q, Cao Z, Zhao Y, Mei J, Li C, Xia P, Xie Z, Xia Z, et al. LC domain-mediated coalescence is essential for Otu enzymatic activity to Extend Drosophila Lifespan. Mol Cell. 2019;74:363–e377365.

Article  CAS  PubMed  Google Scholar 

Song D, Kuang L, Yang L, Wang L, Li H, Li X, Zhu Z, Shi C, Zhu H, Gong W. Yin and Yang regulation of stress granules by Caprin-1. Proc Natl Acad Sci U S A. 2022;119:e2207975119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Wang T, Shi Y, Bai L, Wang S, Guo D, Zhang Y, Qi Y, Chen C, Zhang J, et al. USP42 drives nuclear speckle mRNA splicing via directing dynamic phase separation to promote tumorigenesis. Cell Death Differ. 2021;28:2482–98.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sowa ME, Bennett EJ, Gygi SP, Harper JW. Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009;138:389–403.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Liu S, Li Q, Shi Y, Wu Y, Liu F, Wang S, Zaky MY, Yousuf W, Sun Q, et al. The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer. Cell Death Differ. 2020;27:2710–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Wang T, Zhang X, Cheng S, Chen C, Yang G, Wang F, Wang R, Zhang Q, Yang D, et al. The deubiquitylating enzyme USP35 restricts regulated cell death to promote survival of renal clear cell carcinoma. Cell Death Differ. 2023;30:1757–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng LH, Hsu CC, Tsai HW, Liao WY, Yang PM, Liao TY, Hsieh HY, Chan TS, Tsai KK. ASPM activates hedgehog and wnt signaling to promote small cell Lung Cancer Stemness and Progression. Cancer Res. 2023;83:830–44.

Article  CAS  PubMed  Google Scholar 

Avery JT, Zhang R, Boohaker RJ. GLI1: a therapeutic target for Cancer. Front Oncol. 2021;11:673154.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Endo A, Matsumoto M, Inada T, Yamamoto A, Nakayama KI, Kitamura N, Komada M. Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36. J Cell Sci. 2009;122:678–86.

Article  CAS  PubMed  Google Scholar 

Qin K, Yu S, Liu Y, Guo R, Guo S, Fei J, Wang Y, Jia K, Xu Z, Chen H, et al. USP36 stabilizes nucleolar Snail1 to promote ribosome biogenesis and cancer cell survival upon ribotoxic stress. Nat Commun. 2023;14:6473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang G, Xie GS, Ma L, Li P, Li L, Richard HT. USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5. Neuro Oncol. 2023;25:841–53.

Article  CAS  PubMed  Google Scholar 

Zhang W, Luo J, Xiao Z, Zang Y, Li X, Zhou Y, Zhou J, Tian Z, Zhu J, Zhao X. USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP. Cell Death Dis. 2022;13:1021.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun XX, He X, Yin L, Komada M, Sears RC, Dai MS. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc Natl Acad Sci U S A. 2015;112:3734–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Urbe S, Liu H, Hayes SD, Heride C, Rigden DJ, Clague MJ. Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Mol Biol Cell. 2012;23:1095–103.

Article