World Health Organisation (https://www.who.int/).
Murrison LB, Brandt E, Myers J, Hershey G. Environmental exposures and mechanisms in allergy and asthma development. J Clin Invest. 2019;129(4):1504–15.
Article PubMed PubMed Central Google Scholar
Carlsten C, Blomberg A, Pui M, Sandstrom T, Wing Wong S, Alexis N, et al. Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study. Thorax. 2016;71(1):35–44.
Thurston G, Balmes J, Garcia E, Gilliland F, Rice M, Schikowski T, et al. Outdoor air pollution and new-onset airway disease. An official American Thoracic Society workshop report. Ann Am Thorac Soc. 2020;17(4):387–98.
Article PubMed PubMed Central Google Scholar
Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716–25.
Brusselle GG, Maes T, Bracke KR. Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma. Nat Med. 2013;19(8):977–9.
Kuruvilla M, Lee EH, Lee G. Understanding asthma phenotypes, endotypes, and mechanisms of disease. Clin Rev Allergy Immunol. 2019;56(2):219–33.
Article PubMed PubMed Central Google Scholar
Mesnil C, Raulier S, Paulissen G, Xiao X, Birrell M, Pirottin D, et al. Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest. 2016;126(9):3279–95.
Article PubMed PubMed Central Google Scholar
De Volder J, Vereecke L, Joos G, Maes T. Targeting neutrophils in asthma: a therapeutic opportunity? Biochem Pharmacol. 2020;
Goleva E, Hauk P, Hall C, Liu A, Riches D, Martin R, et al. Corticosteroid-resistand asthma is associated with classical antimicrobial activation of airway macrophages. J Allergy Clin Immunol. 2008;122(3):550–9.
Article PubMed PubMed Central Google Scholar
Brusselle G, Koppelman G. Biological therapies for severe asthma. N Engl J Med. 2022;389:157–71.
Hosoki K, Aguilera-Aguirre L, Brasier A, Kurosky A, Boldogh I, Sur S. Facilitation of allergic sensitization and allergic airway inflammation by pollen-induced innate neutrophil recruitment. Am J Respir Cell Mol Biol. 2016;54(1):81–90.
Article PubMed PubMed Central Google Scholar
Toussaint M, Jackson D, Swieboda D, Guedan A, Tsourouktsoglou TD, Ching YM, et al. Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation. Nat Med. 2017;23(6):681–91.
Article PubMed PubMed Central Google Scholar
Abdo M, Uddin M, Goldmann T, Marwitz S, Bahmer T, Holz O, et al. Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma. Respir Res. 2021;22:1.
Ray A, Kolls JK. Neutrophilic Inflammation in Asthma and Association with Disease Severity. Trends Immunol. 2017;38(12):942–54.
Article PubMed PubMed Central Google Scholar
Wu W, Bleecker E, Moore W, Busse WW, Castro M, Chung KF, et al. Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data. J Allergy Clin Immunol. 2014;133(5):1280–8.
Article PubMed PubMed Central Google Scholar
Moore WC, Hastie AT, Li X, Li H, Busse WW, Jarjour NN, et al. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2014;133(6):1557–63.
Kim J, Natarajan S, Vaickus L, Bouchard J, Beal D, Cruikshank W, et al. Diesel exhaust particulates exacerbate asthma-like inflamation by increasing CXC chemokines. Am J Pathol. 2011;179(6):2730–9.
Article PubMed PubMed Central Google Scholar
De Grove K, Provoost S, Hendriks R, McKenzie A, Seys L, Kumar S, et al. Dysregulation of type 2 innate lymphoid cells and Th2 cells impairs pollutant-induced allergic airway responses. J Allergy Clin Immunol. 2017;139(1):246–57.
Article PubMed PubMed Central Google Scholar
De Volder J, Bontinck A, De Grove K, Dirven I, Haelterman V, Joos G, et al. Trajectory of neutrophilic responses in a mouse model of pollutant-aggravated allergic asthma. Environ Pollut. 2023;329:1.
Dickason R, Huston M, Huston D. Enhanced detection of interleukin-5 in biological fluids utilize murine monoclonal antibodies which delineate dinstinct neutralizing epitopes. Cytokine. 1994;6:647–56.
Debajeet G, Sneka B, Rakesj J, Baban K, Rajesh G. Molecular eludication of pancreatic elastase inhibition by Baicalein. J Biomol Struct Dyn. 2021;40(13):5759–68.
Boivin G, Faget J, Ancey PB, Ghasti A, Mussard J, Engblom C, et al. Durable and controlled depletion of neutrophils in mice. Nat Comm. 2020;11(1):2762.
Takemasa A, Ishii Y, Fukuda T. A neutrophil elastase inhibitor prevents bleomycin-induced pulmonary fibrosis in mice. Eur Respir J. 2012;40(6):1475–82.
Van Hove C, Moerloose K, Maes T, Joos G, Tournoy K. Cigarette smoke enhances Th2-driven airway inflammation and delays inhalational tolerance. Respir Res. 2008;9:1.
Matucci A, Nencini F, Maggiore G, Chiccoli F, Accinno M, Vivarelli E, et al. High proportion of inflammatory CD62L low eosinophils in blood and nasal polyps of severe asthma patients. Clin Exp Allergy. 2023;53(1):78–87.
Curto E, Mateus-Medina E, Crespo-Lessmann A, Osuna-Gomez R, Ujaldon-Miro C, Garcia-Moral A, et al. Identification of two eosinophil subsets in induced sputum from patients with allergic asthma according to CD15 abd CD66b expression. Int J Environ Res Public Health. 2022;19(20):1.
Valencia A, Loffredo L, Misharin A, Berdnikovs S. Phenotypic plasticity and targeting of SiglecF high CD11c low eosinophils to the airway in a murine model of asthma. Allergy. 2016;71(2):267–71.
Rothenberg M. A hidden residential cell in the lung. J Clin Invest. 2016;126(9):3185–7.
Article PubMed PubMed Central Google Scholar
Pera V, Brusselle G, Riemann S, Kors J, Van Mulligen E, Parry R, et al. Parasitic infections related to anti-type 2 immunity monoclonal antibodies: a disproportionality analysis in the food and drug administration’s adverse event reporting system (FAERS). Front Pharmacol. 2023;14:1276340.
Article PubMed PubMed Central Google Scholar
Vultaggio A, Accinno M, Vivarelli E, Mecheri V, Maggiore G, Cosmi L, et al. Blood CD62Llow inflammatory eosinophils are related to the severity of asthma and reduced by mepolizumab. Allergy. 2023;78:3154–65.
Gorski SA, Hahn Y, Braciale T. Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection. PLoS Pathog. 2019;9:9.
Gorski SA, Lawrence M, Hinkelman A, Spano M, Steinke J, Borish L, et al. Expression of IL-5 receptor alpha by murine and human lung neutrophils. PLoS One. 2019;14:8.
Lawrence M, Teague G, Feng X, Welch C, Etter E, Negri J, et al. Interleukin-5 receptor alpha (CD125) expression on human blood and lung neutrophils. Ann Allergy Asthma Immunol. 2022;128(1):53–60.
Jorssen J, Van Hulst G, Mollers K, Pujol J, Petrellis G, Baptista A, et al. Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification. Immunity. 2024;57:1–18.
Busse W, Katial R, Gossage D, Sari S, Wang B, Kolbeck R, et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol. 2010;125(6):1237–44.
Schleich F, Moermans C, Seidel L, Kempeneers C, Louis G, Rogister F, et al. Benralizumab in severe eosinophilic asthma in real life: confirmed effectiveness and contrasted effect on sputum eosinophilia versus exhaled nitric oxide fraction - PROMISE. ERJ Open Res. 2023;9:6.
Scott G, Asrat S, Allinne J, Lim WK, Nagashima K, Birchard D, et al. IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline. Cytokine. 2023;1:1.
留言 (0)