Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis

de Visser KE, Joyce JA. The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell. 2023;41:374–403.

Article  PubMed  Google Scholar 

Giraldo NA, Sanchez-Salas R, Peske JD, Vano Y, Becht E, Petitprez F, Validire P, Ingels A, Cathelineau X, Fridman WH, Sautès-Fridman C. The clinical role of the TME in solid cancer. Br J Cancer. 2019;120:45–53.

Article  PubMed  Google Scholar 

Mao X, Xu J, Wang W, Liang C, Hua J, Liu J, Zhang B, Meng Q, Yu X, Shi S. Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer. 2021;20:131.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zeisberg EM, Potenta S, Xie L, Zeisberg M, Kalluri R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007;67:10123–8.

Article  PubMed  CAS  Google Scholar 

Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest. 2002;110:341–50.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, et al. Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 2011;19:257–72.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med. 2017;214:579–96.

Article  PubMed  PubMed Central  Google Scholar 

Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H. Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016;113:7551–6.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Caller T, Rotem I, Shaihov-Teper O, Lendengolts D, Schary Y, Shai R, Glick-Saar E, Dominissini D, Motiei M, Katzir I, et al. Small extracellular vesicles from Infarcted and Failing Heart accelerate Tumor Growth. Circulation. 2024;149:1729–48.

Article  PubMed  CAS  Google Scholar 

Zhong W, Xiao Z, Qin Z, Yang J, Wen Y, Yu Z, Li Y, Sheppard NC, Fuchs SY, Xu X, et al. Tumor-derived small extracellular vesicles inhibit the efficacy of CAR T cells against solid tumors. Cancer Res. 2023;83:2790–806.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhu G, Cao B, Liang X, Li L, Hao Y, Meng W, He C, Wang L, Li L. Small extracellular vesicles containing miR-192/215 mediate hypoxia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma. Cancer Lett. 2021;506:11–22.

Article  PubMed  CAS  Google Scholar 

Popowski KD, López de Juan Abad B, George A, Silkstone D, Belcher E, Chung J, Ghodsi A, Lutz H, Davenport J, Flanagan M, et al. Inhalable exosomes outperform liposomes as mRNA and protein drug carriers to the lung. Extracell Vesicle. 2022;1:100002.

Article  PubMed  PubMed Central  Google Scholar 

Chang YT, Peng HY, Hu CM, Tien SC, Chen YI, Jeng YM, Chang MC. Pancreatic cancer-derived small extracellular vesical ezrin activates fibroblasts to exacerbate cancer metastasis through STAT3 and YAP-1 signaling pathways. Mol Oncol. 2023;17:1628–47.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu X, Li J, Yang X, Li X, Kong J, Qi D, Zhang F, Sun B, Liu Y, Liu T. Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling. Int J Oral Sci. 2023;15:32.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pinho SS, Reis CA. Glycosylation in cancer: mechanisms and clinical implications. Nat Rev Cancer. 2015;15:540–55.

Article  PubMed  CAS  Google Scholar 

Eichler J. Protein glycosylation. Curr Biol. 2019;29:R229-31.

Article  PubMed  Google Scholar 

Li J, Li X, Guan F. What are the diagnostic capabilities of glycans for breast cancer? Expert Rev Mol Diagn. 2023;23:1–7.

Article  PubMed  Google Scholar 

Kondo K, Harada Y, Nakano M, Suzuki T, Fukushige T, Hanzawa K, Yagi H, Takagi K, Mizuno K, Miyamoto Y, et al. Identification of distinct N-glycosylation patterns on extracellular vesicles from small-cell and non-small-cell lung cancer cells. J Biol Chem. 2022;298: 101950.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Feng H, Liang L, Deng W, Gao J, Li X, Guan F. Sialyl Lewis X decorated integrin α3 on small extracellular vesicles promotes metastasis of bladder cancer via enhancing vascular permeability. Angiogenesis. 2024;27:883–901.

Tan Z, Cao L, Wu Y, Wang B, Song Z, Yang J, Cheng L, Yang X, Zhou X, Dai Z, et al. Bisecting GlcNAc modification diminishes the pro-metastatic functions of small extracellular vesicles from breast cancer cells. J Extracell Vesicles. 2020;10:e12005.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Feng J, Wang Y, Li B, Yu X, Lei L, Wu J, Zhang X, Chen Q, Zhou Y, Gou J, et al. Loss of bisecting GlcNAcylation on MCAM of bone marrow stoma determined pro-tumoral niche in MDS/AML. Leukemia. 2023;37:113–21.

Article  PubMed  CAS  Google Scholar 

He X, Wang B, Deng W, Cao J, Tan Z, Li X, Guan F. Impaired bisecting GlcNAc reprogrammed M1 polarization of macrophage. Cell Commun Signal. 2024;22:73.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Le MT, Hamar P, Guo C, Basar E, Perdigão-Henriques R, Balaj L, Lieberman J. Mir-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest. 2014;124:5109–28.

Article  PubMed  PubMed Central  Google Scholar 

Cao L, Zhou Y, Li X, Lin S, Tan Z, Guan F. Integrating transcriptomics, proteomics, glycomics and glycoproteomics to characterize paclitaxel resistance in breast cancer cells. J Proteom. 2021;243:104266.

Article  CAS  Google Scholar 

Cao L, Zhou Y, Lin S, Yang C, Guan Z, Li X, Yang S, Gao T, Zhao J, Fan N, et al. The trajectory of vesicular proteomic signatures from HBV-HCC by Chitosan-magnetic bead-based separation and DIA-proteomic analysis. J Extracell Vesicles. 2024;13:e12499.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fang Z, Qin H, Mao J, Wang Z, Zhang N, Wang Y, Liu L, Nie Y, Dong M, Ye M. Glyco-decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation. Nat Commun. 2022;13:1900.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tan Z, Lu W, Li X, Yang G, Guo J, Yu H, Li Z, Guan F. Altered N-Glycan expression profile in epithelial-to-mesenchymal transition of NMuMG cells revealed by an integrated strategy using mass spectrometry and glycogene and lectin microarray analysis. J Proteome Res. 2014;13:2783–95.

Article  PubMed  CAS  Google Scholar 

Cheng L, Cao L, Wu Y, Xie W, Li J, Guan F, Tan Z. Bisecting N-Acetylglucosamine on EGFR inhibits malignant phenotype of breast Cancer via Down-Regulation of EGFR/Erk Signaling. Front Oncol. 2020;10: 929.

Article  PubMed  PubMed Central  Google Scholar 

Sasaki T, Knyazev PG, Clout NJ, Cheburkin Y, Göhring W, Ullrich A, Timpl R, Hohenester E. Structural basis for Gas6-Axl signalling. Embo j. 2006;25:80–7.

Article  PubMed  CAS  Google Scholar 

Liu X,

留言 (0)

沒有登入
gif