Kapiteijn E, Marijnen CA, Nagtegaal ID et al (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345:638–646. https://doi.org/10.1056/NEJMoa010580

Article  CAS  PubMed  Google Scholar 

NCCN (2024) Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Rectal Cancer. https://www.nccn.org/patients/guidelines/content/PDF/rectal-patient.pdf. Accessed 12 Novmber 2024

Glynne-Jones R, Wyrwicz L, Tiret E et al (2017) Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 28:iv22–iv40. https://doi.org/10.1093/annonc/mdx224

Article  CAS  PubMed  Google Scholar 

Mohiuddin M, Hayne M, Regine WF et al (2000) Prognostic significance of postchemoradiation stage following preoperative chemotherapy and radiation for advanced/recurrent rectal cancers. Int J Radiat Oncol Biol Phys 48:1075–1080. https://doi.org/10.1016/s0360-3016(00)00732-x

Article  CAS  PubMed  Google Scholar 

Li Y, Wang J, Ma X et al (2016) A review of neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Int J Biol Sci 12:1022–1031. https://doi.org/10.7150/ijbs.15438

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bujko K, Wyrwicz L, Rutkowski A et al (2016) Long-course oxaliplatin-based preoperative chemoradiation versus 5 x 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study. Ann Oncol 27:834–842. https://doi.org/10.1093/annonc/mdw062

Article  CAS  PubMed  Google Scholar 

Ansari N, Solomon MJ, Fisher RJ et al (2017) Acute adverse events and postoperative complications in a randomized trial of preoperative short-course radiotherapy versus long-course chemoradiotherapy for t3 adenocarcinoma of the rectum: trans-tasman radiation oncology group trial (TROG 01.04). Ann Surg 265:882–888. https://doi.org/10.1097/SLA.0000000000001987

Article  PubMed  Google Scholar 

Dossa F, Chesney TR, Acuna SA et al (2017) A watch-and-wait approach for locally advanced rectal cancer after a clinical complete response following neoadjuvant chemoradiation: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2:501–513

Article  PubMed  Google Scholar 

Bahadoer RR, Dijkstra EA, van Etten B et al (2021) Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol 22:29–42. https://doi.org/10.1016/S1470-2045(20)30555-6

Article  CAS  PubMed  Google Scholar 

Jin J, Tang Y, Hu C et al (2022) Multicenter, randomized, phase III trial of short-term radiotherapy plus chemotherapy versus long-term chemoradiotherapy in locally advanced rectal cancer (STELLAR). J Clin Oncol 40:1681–1692. https://doi.org/10.1200/JCO.21.01667

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conroy T, Bosset JF, Etienne PL et al (2021) Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 22:702–715. https://doi.org/10.1016/s1470-2045(21)00079-6

Article  CAS  PubMed  Google Scholar 

Arbea L, Ramos LI, Martínez-Monge R et al (2010) Intensity-modulated radiation therapy (IMRT) vs 3D conformal radiotherapy (3DCRT) in locally advanced rectal cancer (LARC): dosimetric comparison and clinical implications. Radiat Oncol. 5:17. https://doi.org/10.1186/1748-717X-5-17

Article  PubMed  PubMed Central  Google Scholar 

Samuelian JM, Callister MD, Ashman JB et al (2012) Reduced acute bowel toxicity in patients treated with intensity-modulated radiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys 82:1981–1987. https://doi.org/10.1016/j.ijrobp.2011.01.051

Article  PubMed  Google Scholar 

Droge LH, Weber HE, Guhlich M et al (2015) Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy. BMC Cancer 15:750. https://doi.org/10.1186/s12885-015-1812-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng SY, Colborn KL, Cambridge L et al (2016) Acute toxicity with intensity modulated radiotherapy versus 3-dimensional conformal radiotherapy during preoperative chemoradiation for locally advanced rectal cancer. Radiother Oncol 121:252–257. https://doi.org/10.1016/j.radonc.2016.09.010

Article  PubMed  Google Scholar 

Sun Z, Adam MA, Kim J et al (2017) Intensity-modulated radiation therapy is not associated with perioperative or survival benefit over 3D-conformal radiotherapy for rectal cancer. J Gastrointest Surg 21:106–111. https://doi.org/10.1007/s11605-016-3242-8

Article  PubMed  Google Scholar 

Japanese Society for Cancer of the, C. and Rectum (2019) Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: the 3d English Edition [Secondary Publication]. J Anus Rectum Colon. 3:175–195. https://doi.org/10.23922/jarc.2019-018

Brierley JD et al (2017) TNM Classification of malignant tumour. John Wiley & Sons, New York

Google Scholar 

Valentini V, Gambacorta MA, Barbaro B et al (2016) International consensus guidelines on clinical target volume delineation in rectal cancer. Radiother Oncol 120:195–201. https://doi.org/10.1016/j.radonc.2016.07.017.325

Article  PubMed  Google Scholar 

Wo JY et al (2021) Radiation therapy for rectal cancer: executive summary of an astro clinical practice guideline. Pract Radiat Oncol 11:13–25. https://doi.org/10.1016/j.prro.2020.08.004

Article  PubMed  Google Scholar 

Bazan JG, Koong AC, Chang DT (2014) Rectal Cancer. In: Lee NY, Riaz N, Lu JJ (eds) Target volume delineation for conformal and intensity-modulated radiation therapy. Springer, Cham. pp 303–314. https://doi.org/10.1007/174_2014_979

Marks LB, Yorke ED, Jackson A et al (2010) Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys 76:S10–S19. https://doi.org/10.1016/j.ijrobp.2009.07.1754

Article  PubMed  PubMed Central  Google Scholar 

Hong TS, Moughan J, Garofalo MC et al (2015) NRG oncology radiation therapy oncology group 0822: a phase 2 study of preoperative chemoradiation therapy using intensity modulated radiation therapy in combination with capecitabine and oxaliplatin for patients with locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 93:29–36. https://doi.org/10.1016/j.ijrobp.2015.05.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228–247

Article  CAS  PubMed  Google Scholar 

US Department of Health and Human Services (2017) Common Terminology Criteria for Adverse Events (CTCAE) v5.0. https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcae_v5_quick_reference_5x7.pdf. Accessed 12 November 2024

Cancer Therapy Evaluation Program (1998) Common Toxicity Criteria (CTC) v2.0. https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcv20_4-30-992.pdf. Accessed 12 November 2024

Sakanaka K, Fujii K, Ishida Y et al (2022) Preoperative chemoradiotherapy for locally advanced low rectal cancer using intensity-modulated radiotherapy to spare the intestines: a single-institutional pilot trial. J Radiat Res 63:88–97. https://doi.org/10.1093/jrr/rrab106

Article  PubMed  Google Scholar 

Huang CM, Huang MY, Tsai HL et al (2017) A retrospective comparison of outcome and toxicity of preoperative image-guided intensity-modulated radiotherapy versus conventional pelvic radiotherapy for locally advanced rectal carcinoma. J Radiat Res 58:247–259. https://doi.org/10.1093/jrr/rrw098

Article  PubMed  Google Scholar 

Garcia-Aguilar J, Patil S, Gollub MJ et al (2022) Organ preservation in patients with rectal adenocarcinoma treated with total neoadjuvant therapy. J Clin Oncol 40:2546–2556. https://doi.org/10.1200/JCO.22.00032

Article  CAS  PubMed  PubMed Central  Google Scholar